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It is unknown whether native cells in benign breast tissue mediate risk of cancer.We therefore aimed to identify cell types in benign human mammary tissueimmunohistologically using markers of stemness and differentiation, and toinvestigate their possible associations with clinical risk factors for breast cancer.We found that cells that are integrated in benign epithelium and areimmunoreactive for
Understanding the effects of different agricultural practices on the mycorrhizal symbiosis is important for agricultural production and the sustainable use of soil. We investigated the composition and diversity of arbuscular mycorrhizal fungi (AMF) in soils from fields under different agricultural practices (conventional and organic cereal fields, leys and permanent pastures) in southern Sweden. T
We have characterized the dissolved state of microcrystalline cellulose (MCC) in cold alkali [2.0 M NaOH(aq)] solutions using a combination of small angle X-ray (SAXS) and static light scattering (SLS), (Formula presented.)H NMR, NMR self-diffusion, and rheology experiments. NMR and SAXS data demonstrate that the cellulose is fully molecularly dissolved. SLS, however, shows the presence of large c
In the Solar System, asteroids and Kuiper belt objects as well as comets are remnant planetesimals from the time of planet formation. Interactions between solids and gas inside a protoplanetary disc can, e.g. through the streaming instability, form gravitationally bound planetesimal-mass clouds of pebbles. Such clouds will inevitably have inelastic collisions between pebbles, lose energy and exper
This study examines the sharing of research tools among academic scientists in the life sciences and materials sciences in Japan. First, this study investigates material transfer, or the sharing of research tools, based on individual-level negotiation. Statistical analyses suggest that supplier-side scientists decide whether or not to fulfill requests for material transfer on the basis of: expecte
The question whether there is a natural connection between sound and meaning or if they are related only by convention has been debated since antiquity. In linguistics, it is usually taken for granted that 'the linguistic sign is arbitrary,' and exceptions like onomatopoeia have been regarded as marginal phenomena. However, it is becoming more and more clear that motivated relations between sound
In primary hyperparathyroidism (pHPT), a preferential release of intact PTH (i-PTH) versus carboxylterminal PTH fragments is known to occur. We studied whether the release of amino-terminal PTH fragments (N-PTH) is also changed. Serum levels of i-PTH and N-PTH were determined under basal conditions and following oral intake of calcium in six patients with pHPT before and immediately after surgery
The introductory and closing speeches during a conference dedicated to the legacy of the 1915 Genocide, its denial by the Turkish State.
A massive population growth in cities is currently being witnessed in most countries around the world. As urban populations grow, cities eventually expand geographically into what was considered countryside and nowadays distinguishing between what is city and what is countryside is getting increasingly difficult. In many Western countries, it is being observed that areas near cities seem to capita
Agricultural landscapes are characterised by dynamic crop mosaics changing in composition and configuration over space and time. Although semi-natural habitat has been often shown to contribute to pest biological control, the effects of increasing landscape heterogeneity with cropland have been disregarded. Here, we examine how cereal aphids, their enemies and biological control are affected by th
We present a nonperturbative analysis of the power spectrum of energy level fluctuations in fully chaotic quantum structures. Focusing on systems with broken time-reversal symmetry, we employ a finite-N random matrix theory to derive an exact multidimensional integral representation of the power spectrum. The N→ limit of the exact solution furnishes the main result of this study - a universal, par
We present a study of high-order-harmonic generation (HHG) assisted by extreme ultraviolet (XUV) attosecond pulses, which can lead to the excitation of inner-shell electrons and the generation of a second HHG plateau. With the treatment of a one-dimensional model of krypton, based on time-dependent configuration interaction singles (TDCIS) of an effective two-electron system, we show that the XUV-
Objective: Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose and ATP. ATP depletion may impair healing of plaques and promote necrotic core expansion. To investigate if ATP depletion is present in human plaque
Targeted quantitative mass spectrometry of immunoaffinity-enriched peptides, termed immuno-multiple reaction monitoring (iMRM), is a powerful method for determining the relative abundance of proteins in complex mixtures, like plasma or whole tissue. This technique combines 1,000-fold enrichment potential of antibodies for target peptides with the selectivity of multiple reaction monitoring mass sp
Reduced pancreatic b-cell function or mass is the critical problem in developing diabetes. Insulin release from b-cells depends on Ca2+ influx through high voltage- gated Ca2+ channels (HVCCs). Ca2+ influx also regulates insulin synthesis and insulin granule priming and contributes to β-cell electrical activity. The HVCCs aremultisubunit protein complexes composed of a pore-forming a1 and auxiliar
