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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 192508 sökträffar

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The rise of antibiotic-resistant soil microbial communities is a critical global issue. Evidence suggests that heavy metals can select or co-select for tolerance to metals and antibiotics in soil bacteria, but it is unclear if this tolerance varies with land use. We tested the potential of bacterial communities to develop resistance to copper (Cu) or tetracycline (Tet) after amending soils from pr

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Overfishing poses a critical threat to marine ecosystems and local coastal communities worldwide. Designation of Marine Protected Areas, particularly those incorporating No-Fishing Zones, act as refuges from the effects of climate and fishing, serve as valuable biodiversity conservation tools for more resilient social-ecological systems. Nevertheless, to be successful in long-term conservation the

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Premature ovarian failure (POF) is a perplexing condition in women characterized by cessation of oocyte production in the ovaries. Despite numerous proposed causes for the development of POF, the actual cause of the most POF cases remains unknown. Given that POF significantly affects fertility and is a devastating diagnosis for women, there is an urgent need for the development of new therapies ai

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The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive

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Private-sphere conversations about global environmental change play an important role in environmental communication. However, they receive less attention than information campaigns aimed at raising awareness, educating, or challenging the public. From a psychological perspective, it is increasingly recommended to talk about global environmental change and the emotions it evokes as a way of coping

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Biphasic insulin secretion, which fails in type 2 diabetes, can be provoked by various nutrient stimuli, glucose being the superior physiological one. To identify pathways that may play a role in β-cell stimulus-secretion coupling, we compared β-cell and islet functional, secretory, and metabolic responses to glucose and 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), a leucine analog, tha

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The purpose of the present study is to compare the use of three major conjunctions ?and?, ?or? and ?but? by Chinese (Hong Kong) and American university students. The study is also concerned with the position and functions of major conjunctions. Materials from three corpora are used with the help of a concordance for functional analysis, which may be applied to ELT material design and classroom met

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Behandling av personuppgifter, vilket undersöks i denna uppsats, sker i den offentliga och privata sektorn, och i organisationer av alla storlekar. Personuppgiftsbehandlingar förekommer i varje gren av en organisation och hos alla olika aktörer, inom så spridda områden som rättsväsendet eller en frisörsalong. Mer specifikt syftar denna uppsats till att studera definitionen av "behandling"Personal data processing, as will be examined in this thesis, occurs in the public and the private sectors, in organisations of every size. It occurs in every branch of an organisation and by all different actors, be it law-enforcement or a hairdresser saloon. More specifically this thesis aims to study the definition of ‘processing’ and attempts to highlight the features and characterisation of i

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Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous, locomotor, and cardiovascular systems or cause tissue damage. The discovery that certain fish-hunting cone snails use weaponized insulins to induce hypoglycemic shock in prey highlights a unique example of toxins targeting glucose homeostasis. Here, w

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Denna avhandling undersöker 1998 års svenska förbud mot sexköp utifrån den uppmärksamhet lagen fått som ett unikt tillvägagångssätt för att reglera prostitution, den starkt polariserade politiska miljö den existerar inom och de många juridiska motsägelser den uppvisar. Genom material insamlat genom en multisituerad metod mellan åren 2009 och 2019 visar studien att sexköpsförbudet är en variant av

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Resilience – broadly understood as withstanding, and adapting to, shocks and risks – has emerged as a central discursive device for converging humanitarian needs with climate change responses. This paper's human-centred engagement with resilience draws on the case of smallholder farmers engaged in rain-fed cocoa production in Ghana's Central Region, to systematically unpack how poverty shapes smal

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The onset of resistance to artemisinin for malaria treatment has stimulated the quest for novel antimalarial drugs. Herein, the gold(III) coordination complexes Aubipy [Au(bipy)Cl]+ (bipy = 2,2'-bipyridine), Auphen [Au(phen)Cl]+ (phen = phenanthroline), Auterpy [Au(terpy)Cl]2+ (terpy = 2,2';6',2″-terpyridine), and corresponding hydrolyzed species, have been investigated as inhibitors of the Plasmo

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BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and related conditions. In previous registry-based, retrospective studies, autoimmune diseases have been associated with MGUS. However, these studies were not based on a screened population and are therefore prone to ascertainment bias.OBJECTIVE: To examine whether MGUS is associated with

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Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and immunomodulatory agent. Research studies in recent years have shown HDPs play a crucial role in endothelial cell function and biology. The function of endot

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As global climate change intensifies, the question of what makes a place habitable or uninhabitable is critical, particularly in the context of a potential future climate outside the realm of lived experience, and the possible concurrent redistribution of populations partly associated with such climatic shifts. The concept of habitability holds the potential for advancing the understanding of the

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Introduction: The CVA24 antigenic variant is the causal agent of epidemics of acute hemorrhagic conjunctivitis that has prevailed to date. To study the transmission dynamics and evolution of this variant, we molecularly characterized Cuban isolates obtained in 5 epidemic periods between 1986 and 2009. Methods: Using the BEAST v1.8.4 program, it was performed the phylogenetic and phylodynamic analy

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The complex nature of climate change requires action at different scales and in different ways, but questions remain around how to produce climate action that is both multi-scalar and joined up. Here we explore this question by adopting a relational approach to studying climate action by faith-based actors, who increasingly play an active role campaigning on climate action. Drawing on qualitative