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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 193287 sökträffar

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Abstract in UndeterminedAll types of organizations are under increasing pressure to integrate green considerations in their purchasing practices. A number of tools aimed for the practitioners have been developed in response to their new challenges. However, the application of such tools among private firms is not well known, and one important question is how well the tools correspond with practiti

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In a retrospective survey of 450 patients with rheumatoid arthritis on whom cervical spine radiography was performed, one patient was found with a backward tilting of the posterior arch of the atlas. With preserved relations anteriorly, the posterior arch was rotated downward in front of the spinous process of the axis, encroaching on the space of the spinal canal.

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Oral and pharyngeal dysfunction is common in Parkinson's disease. To reveal the frequency of swallowing dysfunction and correlate swallowing dysfunction with locomotor disturbances, we studied 75 patients with Parkinson's disease staged I-IV according to the Hoehn and Yahr score. We assessed oral and pharyngeal swallow during optimal medication by a quantitative test of swallowing (the ROSS test)

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Huntington’s disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is unknown. The aim of this study was to examine body weight changes and weight-regulating factors in HD using the R6/2 mouse model as a tool. We found that R6/2 mice started losing weight at 9 weeks of age. Total locomotor activity was unaltered

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We present a general framework for computing various optimal embeddings of undirected and directed connected graphs in two and multi-dimensional integer lattices in time sub-exponential either in the minimum number n of lattice points used by such optimal embeddings or in the budget upper bound b on the number of lattice points that may be used in an embedding. The sub-exponential upper bounds in

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The role of the endoplasmic reticulum (ER) localized in dendritic spines has become a subject of intense interest because of its potential functions in local protein synthesis and signal transduction. Although it is recognized from electron microscopic studies that not all spines contain ER, little is know of its dynamic regulation or turnover. Here, we report a surprising degree of turnover of ER

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Abstract Let μ be a finite positive measure on the closed disk D¯ in the complex plane, let 1 ≤ t < ∞, and let Pt(μ) denote the closure of the analytic polynomials in Lt(μ). We suppose that D is the set of analytic bounded point evaluations for Pt(μ), and that Pt(μ) contains no nontrivial characteristic functions. It is then known that the restriction of μ to ∂D must be of the

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This paper treats the significance of organization-based social identity for loyalty versus exit reactions with special reference to knowledge-intensive companies. The centrality of network relations and close contact with clients in combination with the sometimes drastic consequences of knowledge workers defecting in many knowledge-intensive companies makes social identification and loyalty cruci

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User driven innovation (UDI) is a popular term in policy and corporate circles. However, it is not clear exactly what UDI means and how such practices are used across the spectrum of companies and over the innovation life cycle. The present study compares 58 UDI showcases in Finnish companies in order to analyse the diversity of UDI practices and their evolution over time. We identify five main mo

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Little is known about the extent to which interactions between genetics and epigenetics may affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We performed a genome-wide DNA methylation quantitative trait locus (mQTL) analysis in human adipose tissue of 119 men, where 592,794 single nucleotide polymorphisms (SNPs) were related to DNA methylation of 477,891 CpG site

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Altricial birds are unable to maintain body temperature when exposed to low ambient temperatures during the first days after hatching. Thermoregulatory capacity begins to form as postnatal development progresses, and eventually nestlings become homeothermic. Several factors may influence this development at both the level of the individual and the level of the whole brood, but to our knowledge no

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Genome-wide association studies (GWAS) have generated considerable interest in glucokinase regulatory protein (GKRP; gene name GCKR) which is an inhibitor of hepatic glucokinase (GCK), an enzyme that plays a critical role in glucose update and disposal in liver. From the initial discovery of GCKR variants associated with triglyceride and glucose levels through the identification of pleiotropic ass

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Uncultivated field boundaries constitute a significant part of the remaining semi-natural habitat in simplified agricultural landscapes, providing habitats for many grassland species. In Europe, agri-environment schemes (AES) offer incentives to farmers to manage farmland more environmentally friendly. In Sweden, one AES has specifically targeted management of incidental habitats on farmland by pr

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Several recent models of choice build on the idea that decision makers are more likely to choose an option if its attributes stand out compared to the attributes of the available alternatives. One example is the model of focusing by Köszegi and Szeidl (2013) where decision makers focus disproportionally on the attributes in which the available options differ more, implying that some attributes wil

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A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized (3)He MRI to detect the build-up of the signal intensity after increasing numbers of (3)He breaths, which allowed for computation of a regional ventilation parameter. A group of six anesthetized

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Following the recent detection of an auroral signal on Uranus (Lamy et al. [2012]. Geophys. Res. Lett. 39, 7105) during HST/STIS observation performed in November 2011, we analyzed the associated HST/STIS FUV spectral images obtained in 2011 and 2012. Our purpose was to extract any possible H2 emission produced in the upper atmosphere of the planet. To interpret these data, we adapted a version of

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Locally induced, magnetic order on the surface of a topological insulator nanowire could enable room-temperature topological quantum devices. Here we report on the realization of selective magnetic control over topological surface states on a single facet of a rectangular Bi2Te3 nanowire via a magnetic insulating Fe3O4 substrate. Low-temperature magnetotransport studies provide evidence for local