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Background: The natriuretic peptides play an important role in salt homeostasis and blood pressure regulation. It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown. Aim: The aim of this study was to examine the association between obesity and natriuretic peptide levels and evaluate the
While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were ide
OBJECTIVE- Some individuals with normal glucose tolerance (NGT) exhibit a 1-h excursion of plasma glucose during oral glucose tolerance testing as high as that of individuals with impaired glucose tolerance (IGT). The aim of this study was to characterize their metabolic phenotype. RESEARCH DESIGN AND METHODS- A total of 1,205 healthy volunteers (aged 29-61 years) underwent assessment of 1) oral g
Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of diabetes. Among 2,422 normoglycemic individuals followed for 12 years, 201 developed diabetes. Amino acids, amines and other polar metabolites were profiled in baseline specimens by liquid chromatography-tan
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously
Cassava cultivars are classified following different criteria, such as cyanogenic glucoside content or starch content. Here, flours from the roots of 25 cassava varieties cultivated simultaneously in a single plantation, were characterized in terms of starch content (SC), amylose content (AC), alpha-amylolysis index (AI) and gel formation ability. Resistant starch content (RS) was measured in 10 o
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels a
There is limited information regarding new ulceration following the healing of ischaemic foot ulcers in diabetic patients. Our aim is to study new ulcerations in the same foot as the previous ulcer(s) in patients with diabetes and severe peripheral artery disease (PAD).
Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
The health impact of dietary replacement of carbohydrates with protein for patients with type 2 diabetes is still debated. This study aimed to investigate the association between dietary substitution of carbohydrates with (animal and plant) protein and 5-year weight change, and all-cause and cardiovascular (CVD) mortality risk in patients with type 2 diabetes.
Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 diabetes (T2D) in humans. Here we analyzed mRNA expression and DNA methylation of PDX-1 in human pancr
We present a theoretical investigation of the hyperfine structure of the 5s5d D-3(2)-5s4f F-3(2,3)0 transitions in In II. Earlier work has failed in determining hyperfine constants for the upper levels of these transitions. We show that this is due to strong off-diagonal hyperfine interaction, which not only changes the position of the individual hyperfine lines but also introduces large intensity
Increased PDGFRA signaling is an essential pathogenic factor in many subtypes of gliomas. In this context the cell surface expression of PDGFRA is an important determinant of ligand sensing in the glioma microenvironment. However, the regulation of spatial distribution of PDGFRA in glioma cells remains poorly characterized. Here, we report that cell surface PDGFRA expression in gliomas is negative
Objectives: Patients with type 1 diabetes mellitus (T1DM) lack the portal/peripheral insulin gradient, which might diminish insulin stimulation of hepatic lipogenesis and protect against development of nonalcoholic fatty liver disease (NAFLD). We compared liver fat content and insulin sensitivity of hepatic glucose production and lipolysis between overweight T1DM patients and nondiabetic subjects.
Detta självständiga arbete i musikpedagogik undersöker elevers kollektiva kompositionsprocesser inom ramen för skolans musikundervisning. Undersökningen har skett med utgångspunkt i ett genomfört kompositionsprojekt med grupper av gymnasieelever vid ett musikestetiskt program i Sverige, vilket ägde rum i samband med den verksamhetsförlagda delen av 2022 års höst-termin vid Musikhögskolan i Malmö.This independent degree project in music pedagogy investigates students collective processes of composition as a part of their music-education in school. The investigation draws upon a composition project with groups of high school students at a Swedish aesthetical high school program, which was carried out in connection with the teaching placement in autumn term 2022 at Malmö Academy of Music. Th
This essay examines the extent to which notions concerning gender structures manifest themselves in the swedish Discrimination Act (SFS 2008:567), by analyzing how the concept of gender is constructed in its preparatory legal work Proposition 2007/08:95 Ett starkare skydd för diskriminering. The area of study is restricted to section 5.2 of the Discrimination Act; transgender identity or expressio
Denna uppsats syftar till att undersöka vilka effekter ett införande av fotboja som ungdomspåföljd skulle innebära för de unga som i så fall skulle komma i fråga för påföljden. Utgångspunkt tas i det förslag på införande av fotboja för unga som återfinns i SOU 2012:34 Nya påföljder, där påföljden kallas för ungdomsövervakning. Inledningsvis tecknas en översiktlig bild av det rättspolitiska dagsläThe aim of this thesis is to examine the potential effects on youths of an introduction of electronic tagging into the Swedish penal system for juveniles. The proposition of such electronic tagging, presented in SOU 2012:34 Nya påföljder (“New sanctions”) by the name ungdomsövervakning (“youth monitoring”), acts as a starting point for the investigation of the expected effects on youths. First,
Title: Food for Thought: Investigating Brand Activism and the Positioning of FMCG Brands in the Plant-Based Space Seminar date: 2022-06-03 Course: BUSN39, Degree Project in Global Marketing - Master Level Authors: Jesper Karlsson & Sophie Weir Advisor: Javier Cenamor Keywords: Brand activism, brand positioning, plant-based brands, FMCG, brand identity Research questions: How do marketing profe
Uppsatsen är en kvalitativ, värderande fallstudie som syftar till att utvärdera International Criminal Tribunal of the former Yugoslavias arbete och försoningsprocessen i Bosnien-Hercegovina. Efter ett krig fyllt av illdåd och folkmord blev det upp till tribunalen ICTY att försöka få de tre etniska parterna att nå försoning genom legal rättvisa. Men vägen till försoning i Bosnien-Hercegovina är sv
