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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 193300 sökträffar

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The demand for rare earth elements (REEs) is growing, while the future supply is uncertain. Their unique electronic characteristics make them irreplaceable, and the commercial value of pure fractions is high. A model-based simulation study is presented that compares batch chromatography with the twin-column MCSGP (multicolumn countercurrent solvent gradient purification) process for ion-exchange c

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Popular Abstract in Swedish Conodonter är en numera utdöd grupp havslevande djur vars systematiska ställning länge varit föremål för debatt. De var i det längsta kända enbart genom sina millimeterstora, kalciumfosfatiska element, vilka vi idag vet satt i djurens munhåla. Sådana conodontelement beskrevs för första gången 1856 av Christian Heinrich Pander, men det skulle dröja närmare 130 år innan dThis thesis deals with conodont biostratigraphy and palaeoecology in the Darriwilian (Middle Ordovician) of Baltoscandia, with focus on limestone strata showing traces of the ~ 470 Ma L-chondrite parent body break-up. The evidence for this cosmic event includes abundant centimeter to decimeter-sized fossil meteorites and elevated levels of sediment-dispersed extraterrestrial L-type chromite found

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Moraxella catarrhalis is an important respiratory pathogen. It is a common cause of otitis media in children, a usual infections agent in sinusitis and makes up to 10% of all exacerbations of chronic obstructive pulmonary disease (COPD). It is known to cause more frequent disease in the colder season, and, generally, its importance is recognised mainly in countries exposed to moderate climate. M.

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HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, derived

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Cuff-occluded rate of rise of peripheral venous pressure has been proposed to reflect volume changes in experimental studies. The aim of this study was to evaluate changes in cuff-occluded rate of rise of peripheral venous pressure associated with fluid removal by haemodialysis in six adult patients with chronic renal failure on intermittent haemodialysis. Measurements were carried out before and

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OBJECTIVE-Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired beta-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS-We have conducted a meta-analysis of genome-wide as

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Objectives To describe clinical and ultrasound features of Brenner tumors of the ovary. Methods In this retrospective study, the databases of the International Ovarian Tumor Analysis (IOTA) studies and one tertiary center were searched to identify patients who had undergone an ultrasound scan before surgery for an adnexal mass that proved to be a Brenner tumor. Twenty-eight patients with 29 Brenne

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Cassava cultivars are classified following different criteria, such as cyanogenic glucoside content or starch content. Here, flours from the roots of 25 cassava varieties cultivated simultaneously in a single plantation, were characterized in terms of starch content (SC), amylose content (AC), alpha-amylolysis index (AI) and gel formation ability. Resistant starch content (RS) was measured in 10 o

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Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insulin, α-cells are electrically excitable and equipped with dif

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We present experiments in which the interaction of a single gold nanoparticle with glass substrates or with another gold particle can be tuned by in situ control of their separations using scanning probe technology. We record the plasmon resonances of the coupled systems as a function of the polarization of the incident field and the particle position. The distinct spectral changes of the scattere

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Background: Moths rely heavily on pheromone communication for mate finding. The pheromone components of most moths are modified from the products of normal fatty acid metabolism by a set of tissue-specific enzymes. The turnip moth, Agrotis segetum uses a series of homologous fatty-alcohol acetate esters ((Z)-5-decenyl, (Z)-7-dodecenyl, and (Z)-9 tetradecenyl acetate) as its sex pheromone component

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Acute cardiovascular events, most commonly caused by rupture of an atherosclerotic plaque, lie behind one third of all deaths worldwide. Atherosclerosis is an inflammatory disease of large and medium sized arteries driven by retention of lipid in the arterial wall. Inflammatory activity in the plaque is believed to be an important driving force behind plaque progression and rupture. However it is

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Pressure overload activates cardiac fibroblasts leading to excessive production of extracellular matrix which may contribute to compromised heart function. The activated fibroblast acquires smooth muscle-like features such as expression of smooth muscle alpha-actin (SMA) and SM22 and is therefore referred to as myofibroblast. The molecular mechanisms underlying mechanical stress-induced myofibrobl

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This study assesses the performance of buildings affected by climate change under future climate predictions for three time-periods until the end of the 21st century. Objects studied are residential multi-storey buildings, originally built before 1970 and retrofitted during the last decade. A total of four actual retrofit projects, as they were performed, in Denmark and Germany were assessed in th

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With this research I have answered the twofold question of how Cuba played a part in the making of the Universal Declaration of Human Rights, and what differences and similarities that can be found between the Cuban draft of Human Rights versus the final product of the Universal Declaration of Human Rights. Since there is no previous research in this field I have chosen to look at some of the most

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The increase in contact resistance within battery systems remains poorly understood, despite being one of the primary contributors to battery degradation. This project aims to investigate this phenomenon by modeling the electrical interface as a contact between a pin and a busbar. The main goal is to build a DOE and machine learning framework, using Bayesian optimization to efficiently explore the

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This bachelor thesis uses firm registration and unemployment data to see if unemployment has an impact on the rate at which firms are formed in Swedish regions in the years 2005-2023. This is done through econometric modelling, namely a linear regression model with region and time specific effects. The results show that there indeed is a relationship between unemployment and firm formation, and sh

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The Tenant of Wildfell Hall (1848) can be read as a protofeminist text and a radical novel for its time, as it confronted the lack of maternal rights and protection for children. In this paper I discuss the portrayal of motherhood, and the factors that empower and restrict Helen. Using Sarah Lewis´s Woman´s Mission (1839) and her contemporary views of maternal duty, this paper explores the complex

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Proteoglycans are macromolecules that play a vital role in mammals, acting as structural elements and ligands for proteins. Proteoglycans consist of a protein core, as well as one or more glycosaminoglycan, a saccharide chain synthesised by cells. This biosynthesis starts through the xylosylation of a serine residue of the core protein, that the glycosaminoglycan is subsequently built on. In vivo