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In a rapidly changing world, it is of fundamental importance to understand processes constraining or facilitating adaptation through microevolution. As different traits of an organism covary, genetic correlations are expected to affect evolutionary trajectories. However, only limited empirical data are available. We investigate the extent to which multivariate constraints affect the rate of adapta
The function of alpha-cells in patients with type 2 diabetes is often disturbed; glucagon secretion is increased at hyperglycaemia, yet fails to respond to hypoglycaemia. A crucial mechanism behind the fine-tuned release of glucagon relies in the exocytotic machinery including SNARE proteins. Here, we aimed to investigate the temporal role of syntaxin 1A and SNAP-25 in mouse alpha-cell exocytosis.
Purpose – The purpose of this paper is to assess how technology-based university research drives innovation in Europe and China. Design/methodology/approach – This paper draws on extensive theoretical research and literature reviews, and presents a framework based on theories on networking, knowledge creation and innovation. It then introduces three European cases to illustrate practical appli
There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. Dur
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This master thesis is a part of an inventory control research collaboration between NGIL (Next Generation Innovative Logistics) and Volvo Parts AB. Volvo Parts is a business unit within the Volvo Group that provides support and services for the aftermarket. Their objective is to maximise the uptime of Volvo Group products for the end users by providing support and ensuring availability of spare pa
Varumärkesrätten inom den Europeiska Unionen förbjuder registreringen av varumärken som är beskrivande för varan eller tjänsten, eller en av dess egenskaper, för vilket varumärket ansöks. Kravet har ansetts vara en undergrupp till det generella kravet på att ett varumärke måste ha särskiljningsförmåga, som krävs för att uppfylla det grundläggande syftet med varumärken, nämligen att identifiera ursThe trademark regime of the European Union prohibits the registration of marks that are descriptive of the goods or services, or their characteristics, for which the mark is applied. This has been interpreted as a sub-group of the general prohibition of marks that lack distinctiveness and that thusly cannot fulfil the essential function of trademarks, i.e. identifying origin. However, while some
Bumblebees and other pollinators are important contributors to the ecosystem service of pollination of wild plants and crops. As in many pollinating insects, their abundance and diversity have declined in recent years, due to loss of natural habitats and fragmentation associated with urbanization and agricultural intensification. However, in urban areas, green space management beneficial to pollin
In the radioimmunotherapy of malignancies the uptake of monoclonal antibodies (MoAb) is commonly low in tumors compared with normal tissue. Several methods have been suggested to increase the tumor-to-normal tissue (T/N) ratio. In this study we have investigated the biodistribution of different amounts of 125I-L6-biotin MoAb in combination with a preload of unlabeled L6 MoAb. Nude rats were inject
In this article I examine the development of the idea of marriage as a personal union whose foundation is the relation between the spouses. The theories which developed within the Church from the eleventh century and onwards put the emphasis on the personal side of marriage; the sacrament of marriage was founded on the union between the spouses and not on family interest. From the middle of the tw
With the new governing structures created through the transitional administration of the United Nations (UN), old and new fault lines in the past decade have exposed themselves in Timor-Leste: rural-urban divides, generational divides, communal divides, and political divides. This paper utilises Anthony D. Smith’s ethno-symbolism approach to understanding nationalism by focusing on subjective elem
Syftet med uppsatsen är att kritiskt belysa, analysera och diskutera turordningsreglernas rättsliga innebörd och rättspolitiska diskurs i ett svenskt och EU-rättsligt perspektiv. Lagen om anställningsskydd trädde i kraft 1974 och har allt sedan dess varit en av de mest omdiskuterade svenska lagstiftningarna. I centrum för diskussionen står turordningsreglerna. Anledningen till att frågan blivit The purpose of this thesis is to critically highlight, analyze and discuss the priority rules, their judicial meaning and legal policy discourse in a Swedish and European legal perspective. The Act on Employment came into force in 1974 and since then it has been one of the most controversial legislations in Sweden. At the very center of the debate are the priority rules. The reason that the rules
Det har visat sig att fysisk aktivitet minskar risken för en rad olika sjukdomar. Studien syftade till att undersöka fysisk aktivitet i olika kontexter och på olika nivåer för att bidra med ny kunskap om eventuella hälsofördelar med fysisk aktivitet. Då det är betydelsefullt för organisationens effektivitet och produktivitet att de anställda mår bra är det också viktigt att organisationen arbetar Physical activity has been shown to reduce the risk of several illnesses. The study aimed to investigate physical activity in different contexts and on different levels to contribute with new knowledge about possible health benefits linked to physical activity. Since the health of the employees is crucial for the organization’s efficiency and productivity it is important that organizations promote
Den här uppsatsen undersöker allmänt tandvårdsbidrags (ATB) påverkan på tandvårdsbesök. Difference-in-differences (DiD) metoden applicerades på tvärsnittsdata från SCB:s ”Undersökningarna av Levnadsförhållanden” (ULF), där intensitets-differensen i ATB för åldersgrupper nyttjades. DiD-estimaten för tidsperioderna som uppfyllde parallell-trend-antagandet hade en statistiskt signifikant effekt på t
Svenska elitidrottares mentala träningsvanor undersöktes genom en webbaserad enkätundersökning som besvarades av 47 aktiva idrottare (28 män, 19 kvinnor, ålder 16-37, M=25) inom fotboll, friidrott, handboll, ishockey och tennis. Studien visade att svenska elitidrottare i genomsnitt ägnar 41 minuter i veckan åt olika mentala träningsformer, dock med stor individuell spridning. Mängden mental träninThis paper aimed to study to what extent Swedish elite athletes engage themselves in psychological skills training (PST). The study was conducted through a web-based survey with 47 respondents (28 men, 19 women, age 16-37, M=25) from five sports; handball, ice hockey, soccer, tennis and track and field. The results showed that the athletes spend on average 41 minutes a week on different types of m
The sequence of events for secreting insulin in response to glucose in pancreatic β-cells is termed “stimulus-secretion coupling”. The core of stimulus-secretion coupling is a process which generates electrical activity in response to glucose uptake and causes Ca2+ oscillation for triggering exocytosis of insulin-containing secretory granules. Prior to exocytosis, the secretory granules are mobili
Identifying field management practices to promote crop production, while conserving soil health is essential to maintain long-term food production in a changing world. Also, providing experimental evidence to support the use of traditional agricultural practices is necessary to secure sustainable agriculture. Here, we conducted a long-term 12-year experiment to investigate the impact of different
Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofactor-bound forms, key information is missing due to technical limitations, including (a) the location
