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The bioeconomy at the watershed scale project is a project initiated by the International Institute of Sustainable Development situated in Manitoba Canada. This project aims to create a bioeconomy using the Common Cattail as the feedstock, while also creating ecosystem services in the watershed through the maintenance of cattail cover. These services include decreasing nutrient loading into Lake W
The MICOS complex protein MicF has recently been identified to play a vital role in the mitochondrial DNA inheritance checkpoint, a control system that halts cell cycle progression in cells lacking mitochondrial DNA (mtDNA). We show in this report that another member of the complex, MicA, also plays an important role in the mtDNA inheritance checkpoint as its deletion led to cell cycle progression
In the aftermath of the terror attacks on New York in September 2001 several iniativies are set up to protect global supply chains from larger disruptions by antagonistic threats such as terrorism or piracy. Many security initiatives such as the International Ship and Port Security (ISPS) code, the Container Security Initiative (CSI) or the Authorized Economic Operator (AEO) are targeting the mari
This thesis focuses on seasoned equity offerings and aims to examine announcement effects and long-run performance of SEO firms on the Swedish stock exchanges, during the recovery phase of the global financial crisis. Also, an OLS regression is run in order to explain post-SEO performance using the independent variables book-to-market ratio, market capitalization and the firms’ number of SEOs duri
The first aim of this study is to investigate what it takes for a nonprofit association (NPA) to become a legal entity, specifically regarding requirements addressing decision-making organs within the NPA’s organization. Secondly, since within the legal framework of associations there exist general principles of law, this study also explores which general principles of law are applicable to a gene
Personal data is often the target of people who are not responsible for being misused. Theft is done to benefit from people who have the data. In addition to the theft of work files, theft is also carried out on video files. Theft of this file aims to find out what the contents of the video. Someone has a private recorded video that cannot be known by others. Misuse of video files will be fatal fo
Despite considerable progress in schizophrenia genetics, most findings have been for large rare structural variants and common variants in well-imputed regions with few genes implicated from exome sequencing. Whole genome sequencing (WGS) can potentially provide a more complete enumeration of etiological genetic variation apart from the exome and regions of high linkage disequilibrium. We analyze
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating following transplantation and have recently advanced to clinical trials for Parkinson's disease (PD). However, pre-clinical studies have highlighted the low proportion of DAns within hPSC-derived grafts and their inferior plasticity compared to fetal tissue. Here, we examined w
Background: The worries of next of kin about their older loved ones in nursing homes can be extensive and can adversely affect their subjective experiences of their own physical, mental and social well-being. It is thus of utmost importance to measure the quality of life of next of kin in a valid and reliable way. Methods: The design is a cross-sectional study with psychometric evaluation based on
Obesity is a risk factor for type 2 diabetes (T2D); however, not all obese individuals develop the disease. In this study, we aimed to investigate the cause of differential insulin secretion capacity of pancreatic islets from donors with T2D and non-T2D (ND), especially obese donors (BMI ≥30 kg/m2). Islets from obese donors with T2D had reduced insulin secretion, decreased β-cell exocytosis, and h
We identified apolipoprotein E (ApoE) as one of the proteins that are found in complex with complement component C4d in pooled synovial fluid of rheumatoid arthritis (RA) patients. Immobilized human ApoE activated both the classical and the alternative complement pathways. In contrast, ApoE in solution demonstrated an isoform-dependent inhibition of hemolysis and complement deposition at the level
Meteoric beryllium-10 (10Be) is commonly used as a proxy of landscape dynamics (erosion and sedimentation rates) and soil development. Soil represents the first-stage reservoir of meteoric 10Be, and variability in the concentration of the isotope in soils may be affected by soil properties and atmospheric deposition. Although many investigations have targeted this issue, there are still problems i
Climate change is exposing high-latitude systems to warming and a shift towards more shrub-dominated plant communities, resulting in increased leaf-litter inputs at the soil surface, and more labile root-derived organic matter (OM) input in the soil profile. Labile OM can stimulate the mineralization of soil organic matter (SOM); a phenomenon termed “priming.” In N-poor subarctic soils, it is hypo
Hypothesis: The stability of colloidal dispersions in the presence of multivalent ions depends strongly on the electrostatic interactions between the suspended particles. Of particular interest are colloidal particles having dimensions in the nanometric range and with an anisotropic shape due to its high surface area per unit mass, for example clay, which has the key characteristic of a negatively
Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n = 120 756) aged ≥45 years diagnosed with AF in Sweden diagnosed for the period 1998-2006. Outcome was incident congestive heart failure (follow-up 20
Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–environment interactions, and their role in disease pathogenesis. Blood is an obvious alternative and in this proof of principle study, our aim was to systematically investigate whether blood is a viable surrogate for bone. We measured epigenome-wide DNA methylation at 850 K CpG sites in matched trabecula
Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers fr
Credit expansion is the trend of households gaining access to more credit. It is correlated with increasing socio-economic heterogeneity of indebted homeowners. Increasing heterogeneity implies that a more diverse span of homeowners is put at risk of foreclosure. This empirical study explores socio-economic heterogeneity in the case of Swedish debtors in foreclosure between 2000 and 2014. Employin
Nature-based solutions (NbS) are gaining traction in high-level, decision-making arenas as a response to global policy challenges. Claiming to be transformative and pluralistic, NbS aim to resolve societal problems through a focus on nature, which is understood to be a benign ally. This uncritical framing of nature may have unintended and inequitable consequences that undermine the emancipatory po
