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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 193287 sökträffar

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During the last decade the variation in the human genome has been mapped in fine detail. Next generation sequencing has made it possible to cheaply and rapidly aquire vast amounts of biomolecular information on large cohorts of people. This have enabled large-scale epidemiological studies to investigate the relationships between environmental and genetic factors and human biomolecular traits. It i

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he traditional Swedish monocentric and uniform legal model is challenged by an increasingly diverse contemporary legal situation associated with the development of a multicultural and pluralistic society. How Swedish criminal courts handle this in terms of understanding and framing minority legal culture is addressed by looking into what role is given to this culture in the courts’ construction of

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Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adipone

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Background. Knowledge on the globally outstanding Amazonian biodiversity and its environmental determinants stems almost exclusively from aboveground organisms, notably plants. In contrast, the environmental factors and habitat preferences that drive diversity patterns for micro-organisms in the ground remain elusive, despite the fact that micro-organisms constitute the overwhelming majority of li

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Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequ

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We present the measurement of a new set of jet shape observables for track-based jets in central Pb-Pb collisions at sNN=2.76 TeV. The set of jet shapes includes the first radial moment or angularity, g; the momentum dispersion, pTD; and the difference between the leading and sub-leading constituent track transverse momentum, LeSub. These observables provide complementary information on the jet fr

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The local magnetic field inside and around an object in a magnetic resonance imaging unit depends on the magnetic susceptibility of the object being magnetized, in combination with its geometry/orientation. Magnetic susceptibility can thus be exploited as a source of tissue contrast, and susceptibility imaging may also become a useful tool in contrast agent quantification and for assessment of ven

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We present one-color (IR) and two-color (single attosecond XUV pulse + IR) experiments where the sub-cycle evolution of the electric field of light is used to control the dissociative ionization of hydrogen and deuterium molecules.

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We discuss the role of many-electron interactions in multiphoton multielectron ionization of heavy atoms and try to indicate the relative importance of collective effects and screening, relaxation and shakeup, and Fermi sea correlations. The purpose of the work is to look for approximations in which the photoemission processes have been renormalized in consistent ways with respect to the field and

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Diverse and complex interactions as well as multi-actor systems characterise resource use and re- source policy. This makes system analysis a relevant tool to orient resource policy towards the long term. Analysing such complex systems requires systemic thinking, consideration of causal loops as well as time-lags and delays in system responses.In the SimRess project, system analysis encompassed pa

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BACKGROUND: It has been suggested that endoscopic grading of the gastroesophageal flap valve is a good predictor of the reflux status.METHODS: To test this hypothesis, 268 symptomatic patients underwent endoscopic grading of the gastroesophageal valve using Hill's classification, with grades I through IV. Esophageal acid exposure, lower esophageal sphincter characteristics, and the degree of esoph

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The “wooded-meadows system” is a multifunctional use of vegetation resources widespread in Europesince the Neolithic, and well documented in the Ligurian Apennines (NW Italy) between the MiddleAges and the first half of the 19th century. The management of wooded-meadows included: collectionof fallen and dead branches in spring, later used for fuel; mowing and grazing in summer; collection ofsecond

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INTRODUCTION: Matrix metalloproteinases (MMP) are believed to be involved in the pathologic processes behind Alzheimer's disease (AD). In this study, we aimed to examine the cerebrospinal fluid (CSF) levels of MMPs and tissue inhibitors of metalloproteinase-1 (TIMP-1) in individuals with AD dementia and cognitively healthy elderly individuals, and to investigate their relationship with established

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The frequency-dependence of the induced polarization effect (IP), in the so-called spectral IP (SIP), has been demonstrated to be strongly correlated to important parameters in hydrogeological and environmental investigations. This has prompted the development of measuring instruments and modelling techniques towards the collection of laboratory and field data with enhanced accuracy and at a broad

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In this presentation, I will summarize our findings on the effects of reindeer-induced vegetation transitions on carbon cycling processes and storage. These are monitored in subarctic Northern Norway alongside reindeer pasture rotation fences. At these sites, a yearly pulse of intensive reindeer grazing has turned the vegetation from shrub-dominated towards graminoid-dominated. We monitor the deve

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In France, illegal hunting of the endangered ortolan bunting Emberiza hortulana has been defended for the sake of tradition and gastronomy. Hunters argued that ortolan buntings trapped in southwest France originate from large and stable populations across the whole of Europe. Yet, the European Commission referred France to the Court of Justice of the European Union (EU) in December 2016 for infrin