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Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen dyskinesias in parkinsonian rats; however, unraveling which specific neurosteroid mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, s
Two types of CTABr-silica mesophases have been prepared, one of them a powder with hexagonal structure containing Congo Red, another one a film with cubic structure containing Disperse Red 1. In the former case the dye has been occluded via co-entrapping, whereas in the latter it has been covalently anchored to the silica matrix via a co-condensation route. In both systems, the dye molecules prove
This special issue examines anti-gender politics in the specific geographical and cultural space of Eastern Europe. It investigates whether the region is just another battlefield for anti-gender politics, or a unique setting for specific developments and strategies, considering the impact and legacy of specific historical experiences and sociological and cultural characteristics. The contributions
Understanding the effects of tree species and their mycorrhizal association on soil processes is critical for predicting the ecosystem consequences of species shifts owing to global change and forest management decisions. While it is well established that forests dominated by different mycorrhizal types can vary in how they cycle carbon (C), nitrogen (N) and phosphorus (P), the degree to whi
In this study, we examine the development of age at leaving the parental household in Sweden between the years 1830-1959. We utilize individual-level longitudinal data from two geographically and socioeconomically different regions: the county of Scania in the very south of Sweden, and Västerbotten to the north. We use descriptive and multivariate analyses to investigate how determinants, such as
To examine the risk of post-polio syndrome (PPS) in immigrant groups using native Swedish-born individuals as referents. This is a retrospective study. The study population included all individuals aged 18 years and older registered in Sweden. PPS was defined as having at least one registered diagnosis in the Swedish National Patient Register. The incidence of post-polio in different immigrant gro
Historiska aktörer är långt ifrån frånvarande i historieforskningen. Varje land och varje tidsepok har sin beskärda del av biografier över framstående vetenskapsmän, intellektuella och utbildningsreformatorer. Trots detta är det inte fel att hävda att de teoretiska strömningar som har satt sin prägel på historiska och sociologiska studier av kunskap sedan 1960-talet har betonat strukturer framför Historical actors are central to the history of knowledge as they are to all historical scholarship. Every country, every era has its biographies of eminent scientists, intellectuals, and educational reformers. Yet the theoretical currents that have left their mark on the historical and sociological study of knowledge since the 1960s have emphasized structures over actors, collectives over individ
Downregulation of the DNA repair protein WD40-encoding RNA antisense to p53 (WRAP53) has been associated with radiotherapy resistance and reduced cancer survival. The aim of this study was to evaluate WRAP53 protein and RNA levels as prognostic and predictive markers in the SweBCG91RT trial, in which breast cancer patients were randomized for postoperative radiotherapy. Using tissue microarray and
As the world experiences increasing freshwater crises, researchers turn to saline waters. Can the use of saltwater be expanded? The development of appropriate practices for the use of saline waters for irrigation requires an adequate understanding of how salts affect waters, soils and plants, as FAO states in their book The use of saline waters for crop production, 1992. Plants can grow in saline
α-Synuclein aggregates constitute the pathology of Lewy body (LB) disease. Little is known about the effects of LB pathology in preclinical (presymptomatic) individuals, either as isolated pathology or coexisting with Alzheimer's disease (AD) pathology (β-amyloid (Aβ) and tau). We examined the effects of LB pathology using a cerebrospinal fluid α-synuclein-seed amplification assay in 1,182 cogniti
Researchers have increasingly sought to account for the ways in which financial systems permeate everyday life, interpolating individuals as entrepreneurial investor subjects. This article examines why some people reject such financial opportunities as unwilling subjects. This issue is examined in the context of the Moroccan housing market and the associated financial products and services deploye
Operando powder X-ray diffraction (PXRD) is a widely employed method for the investigation of structural evolution and phase transitions in electrodes for rechargeable batteries. Due to the advantages of high brilliance and high X-ray energies, the experiments are often carried out at synchrotron facilities. It is known that the X-ray exposure can cause beam damage in the battery cell, resulting i
Flavonoid compounds like anthocyanins and proanthocyanidins are important plant secondary metabolites having wide biological activities for humans. In this study, the molecular function of the Ant13 locus, which is one of the key loci governing flavonoid synthesis in barley, was determined. It was found that Ant13 encodes a WD40-type regulatory protein, which is required for transcriptional activa
The unique properties of elastomeric materials are taken advantage of in many engineering applications. Elastomeric units are used as couplings or mountings between stiff structures. Examples of these are shock absorbers, vibration insulators, flexible joints, seals and suspensions.The development of computers and of analysis programs in this area has given engineers a new tool for the design of e
When dealing with urban design, it is essential to have knowledge of the magnitude of the spatial variability of short high-intensive rainstorms. Most of the studies of high-intensive rainfall, conducted during recent years, concern regions with a humid climate. Still, the largest temporal and spatial variations in rainfall are to be found in arid and semi-arid regions. This paper sums up findings
