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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 195610 sökträffar

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Presence–absence surveys are a commonly used method for monitoring broad-scale changes in wildlife distributions. However, the lack of power of these surveys for detecting population trends is problematic for their application in wildlife management. Options for improving power include increasing the sampling effort or arbitrarily relaxing the type I error rate. We present an alternative, whereby

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Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer

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Formation of calcium oxalate incrusts, scaling, may cause severe problems in the pulp and paper industry. Enzymatic degradation of oxalic acid provides a novel approach to eliminate the problems with calcium oxalate precipitation. The performance of two oxalate-degrading enzymes, oxalate oxidase from barley and oxalate decarboxylase from Aspergillus, was tested in model experiments with respect to

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The alpha-adrenoceptor-mediated contractile effects of noradrenaline (alpha 1 + alpha 2), phenylephrine (alpha 1) and clonidine (alpha 2) on human saphenous veins were investigated in vivo and in vitro. By infusion (0.3 ml min-1) of the drugs (increasing concentrations in the infused solution) into distended (40 mmHg) saphenous veins in six healthy subjects, local vasoconstriction was induced, mea

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The epitome of this article is the reflection upon the question of “How long is now?” This question is interpreted within the context of the Iraq war, 2003 and onwards, as the enduring now specified. Drawing on parallels from the European World War II experience and the use of “Auschwitz” as a metaphor for a specifically Christian guilt articulated in relation to the Pauline eschatological hope of

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The dissertation is written within the project Strengthening Legal Education in Vietnam.

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The recently increased scholarly interest in pseudo script has opened a somewhat new avenue within traditional Egyptological studies, offering a deeper insight into marking systems which traditionally are not included within the boundaries of established written languages and/or iconographical representation. Thus, in addition to studying the rich and well preserved demotic and Greek inscriptions

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This article explores how the NT accounts of the rending of the veil in the Temple at the time of Jesus have been interpreted: as a sign of wrath, joy and grief.

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We present Ar-40/Ar-39 data acquired by infra-red (CO2) laser step-heating of alunite crystals from the large Miocene Colquijirca district in central Peru. Combined with previously published data, our results show that a long (at least 1.3 My) and complex period of magmatic-hydrothermal activity associated with epithermal Au-(Ag) mineralization and base metal, Cordilleran ores took place at Colqui

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The sequence diversity of the entire mitochondrial control region (CR) of three meadow viper (Vipera ursinii) populations was analysed and compared to previously documented nuclear genetic variability at the major histocompatibility complex (MHC) Class I loci. One of the populations, a small and inbred Hungarian population, exhibited no MHC polymorphism, whereas the two other, sampled from large v

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BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA)

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PURPOSE: To compare the clinical outcome after carpal tunnel release in diabetic and nondiabetic patients. METHODS: We evaluated a prospective, consecutive series of 35 diabetic patients (median age, 54 years; 15 with type 1 and 20 with type 2 diabetes) with carpal tunnel syndrome, who were age- and gender-matched with 31 nondiabetic patients (median age, 51 years) having idiopathic carpal tunnel

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We have addressed the importance of B cell tolerance to collagen type II, a matrix protein, which is a target in rheumatoid arthritis (RA) and its mouse models. We generated a germline-encoded anti-collagen type II (CII) IgH replacement anti-C1 B cell mouse strain (ACB) to investigate how B cell tolerance to CII, a matrix protein, is subverted and to further understand pathogenesis of RA. Phenotyp

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Abstract in UndeterminedIn recent years, there has been a marked proliferation in the literature on economic approaches to ecosystem management, which has created a subsequent need for real understanding of the scope and the limits of the economic approaches to ecosystems and biodiversity. Within this Handbook, carefully commissioned original contributions from acknowledged experts in the field ad

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Many extensions of the Standard Model posit the existence of heavy particles with long lifetimes. In this Letter, results are presented of a search for events containing one or more such particles, which decay at a significant distance from their production point, using a final state containing charged hadrons and an associated muon. This analysis uses a data sample of proton-proton collisions at

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Climate change, manifested through flooding, landslides, and erosion, poses increasing challenges for the built environment. In Sweden, nearly 90 percent of the population resides in urban areas, which were planned under past climatic conditions and are often difficult to adapt retroactively. Spatial planning plays a crucial role in addressing this issue, with municipalities holding central respo