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PurposeArchitectural theorists have a long tradition of acknowledging the centrality of building users to architectural production. This article contributes to the discourse on architecture, actor–network theory (ANT), and users by proposing a typology of user translations ranging from supporting to tinkering to adjusting to resisting.Design/methodology/approachThe research utilises an ANT-inspire
The growing menace of global warming and restrictions on access to water in each region is a huge threat to global hydrological sustainability. Hence, the perspective at which hydrological studies are currently being carried out across the world to quantify and understand the water cycle modeling requires a further boost. In the past few decades, the theoretical understanding of machine learning (
The investigation of compounds capable of strongly and selectively interacting with DNA comprises a field of research in constant development. In this work, we demonstrate that a trinuclear coordination complex based on a dinuclear Fe(III)Zn(II) core designed for biomimicry of the hydrolytic enzyme kidney bean purple acid phosphatase, containing an additional pendant arm coordinating a Pd(II) ion,
Induced neurons (iNs), the product of somatic cells directly converted to neurons, are a way to obtain patient-derived neurons from tissue thatis easily accessible. Through this route, mature neurons can be obtained in a matter of a few weeks. Here, we describe a straightforward andrapid one-step protocol to obtain iNs from dermal fibroblasts obtained through biopsy samples from adult human donors
Lysosomal cell death is triggered by lysosomal membrane permeabilization (LMP) and subsequent release of lysosomal hydrolases from the lysosomal lumen into the cytosol. Once released into the cytosol, the lysosomal cathepsin proteases act as executioner proteases for the subsequent cell death-either autonomously without caspase activation or in concert with the classical apoptotic machinery. Lysos
In recent years, the study of polarisation vision in animals has seen numerous breakthroughs, not just in terms of what is known about the function of this sensory ability, but also in the experimental methods by which polarisation can be controlled, presented and measured. Once thought to be limited to only a few animal species, polarisation sensitivity is now known to be widespread across many t
A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, t
Background: Patients with lumbar disc herniation are treated with physiotherapy/medication and some with surgery. However, even after technically successful surgery some develop a failed back syndrome with persistent pain. Our aim was to evaluate the efficacy of epiduroscopy in patients who suffer chronic low back pain and/or radicular pain with or without surgery and the gender difference in outc
Effects of graphene ethylene glycol/water nanofluids as the hot side fluid on heat transfer and pressure drop characteristics in a brazed plate heat exchanger (BPHE) were experimentally investigated. Nanofluid properties, especially thermal conductivity and viscosity of the graphene nanofluids were measured at various graphene concentrations (0.01 to 1.0% wt.) and temperatures (10 to 60 °C). Dimen
We qualitatively analysed how and why environmental improvement actions often lead to unintended environmental consequences. Different theories are integrated to delineate the underlying system structure causing this system behavior. Causal loop diagram technique is utilized to explore and visualize: how incremental improvements in material and energy efficiency can unintendedly cause consumption
We have studied the adsorption of two silane compounds, (3-mercaptopropyl) trimethoxysilane (MPTMS) and n-propyltriethoxysilane (PTES), on a rutile TiO2(110) surface using angle dependent X-ray photoelectron spectroscopy. The observation of the S 2p line, in the case of MPTMS, and the C 1s line for both MPTMS and PTES confirms the adsorption of the molecules. For a dose of 122 Langmuirs of MPTMS w
We examine how the gender of a sibling affects labor market outcomes and family formation. Identification is complicated by parental preferences: if parents prefer certain sex compositions over others, children’ s gender affects not only the outcomes of other children but also the existence of potential additional children. We employ two empirical strategies that both address this problem. First,
PalCom is a middleware toolkit for pervasive computing and internet-of-things. We discuss how PalCom supports exploration and live programming through three phases: exploring services, assembling them into applications, and exposing them as new services. We give an example of this workflow through the construction of a simple photo booth application.
This paper is an empirical examination of the determinants of aggregate health care expenditure. The paper presents a systematic analysis of relationships across 19 OECD countries, showing the effects of aggregate income, institutional and socio-demographic factors on health care expenditure. The results indicate that institutional factors of the health systems, in addition to per capita Gross Dom
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow disease progression (long CAG repeat R6/2 and zQ175-KI). Both were crossed with a transgenic mouse line expressing eGFP in iSPNs. Using the open-fie
According to the standard story given by reductive versions of the Causal Theory of Action, an action is an intrinsically mindless bodily movement that is appropriately caused by an intention. Those who embrace this story typically take this intention to have a coarse-grained content, specifying the action only down to the level of the agent’s habits and skills. Markos Valaris (2015) argues that,
We outline a conceptual strategy for implementing conservation interventionsin a multiscale, multiactor, and multilevel governance world. Using farmlandas an example, we argue that conservation interventions should be implementedwithin a multiscale framework of guiding ecological principles. Inthis context, findings from multilevel governance research can inform a nuancedunderstanding of the role
The new aminoalcohol phenol 2,4-di-tert-butyl-6-(((2-hydroxy-2-phenylethyl)amino)methyl)phenol (H2L) was prepared by a facile solvent-free synthesis and used as a tridentate ligand for new cis-dioxomolybdenum(vi)(L) complexes. In the presence of a coordinating solvent (DMSO, MeOH, pyridine), the complexes crystallise as monomeric solvent adducts while in the absence of such molecules, a trimer wit
