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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 192517 sökträffar
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Significant collaborations with research partners in China are seen in many Western countries. With increasing US-China geopolitical tensions, governments, research institutions, and individuals in established scientific systems are increasingly required to address a proliferating array of risks and challenges associated with collaboration with China. Academic researchers are only beginning to des
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Vascular dysfunction is a hallmark of systemic inflammatory responses such as bacterial sepsis. The luminal surface of the blood vessels is coated with a dense layer of glycans and proteoglycans, collectively known as the glycocalyx. Surface associated glycoproteins of endothelial origin, or derived from pericytes, intravascular leukocytes, and plasma, are other important components of the glycoca
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The relationship between bariatric surgery and alcohol use disorder (AUD) suggests that there may be a parallel connection between bariatric surgery and gambling disorder (GD), although this has never been researched before. Here, we describe observations suggesting that patients undergoing bariatric surgery may develop gambling disorders after surgery. Obese, older adults, and women may be at par
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Sequencing of reduced representation libraries enables genotyping of many individuals for population genomic studies. However, high amounts of DNA are required, and the method cannot be applied directly on single cells, preventing its use on most microbes. We developed and implemented the analysis of single amplified genomes followed by restriction-site-associated DNA sequencing to bypass labor-in
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Human fetal hemoglobin (HbF) is an attractive starting protein for developing an effective agent for oxygen therapeutics applications. This requires that HbF can be produced in heterologous systems at high levels and in a homogeneous form. The introduction of negative charges on the surface of the α-chain in HbF can enhance the recombinant production yield of a functional protein in Escherichia co
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Ceramic technology makes an abrupt appearance in the New World Arctic at circa 2800 cal BP. While there is general consensus that the ultimate source of these Alaskan pottery traditions lay in continental NE Asia, the motivations for the adoption of pottery in Alaska have remained unclear. Through organic residue analysis we investigated the function of Norton pottery in Southwest Alaska, and the
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Among the hundreds of known hot Jupiters (HJs), only five have been found to have companions on short-period orbits. Within this rare class of multiple planetary systems, the architecture of WASP-47 is unique, hosting an HJ (planet-b) with both an inner and an outer sub-Neptunian mass companion (-e and -d, respectively) as well as an additional non-transiting, long-period giant (-c). The small per
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OBJECTIVE: Communication about patients' values, goals, and prognosis in serious illness (serious illness communication) is a cornerstone of person-centered care yet difficult to implement in practice. As part of Serious Illness Care Program implementation in five health systems, we studied the clinical culture-related factors that supported or impeded improvement in serious illness conversations.
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In this paper we understand cities today as commodified spaceswhich must struggle at the intersection of cultural, ideological andhistorical tensions. In order to explore and problematisea contested city brand’s marketing effort, we engage in multiplerounds of in-situ introspective reflections about a racialised city’splace branding material. Based on the two authors’ separate analysesof the same
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Based on the combination of two regular Gallager (Low-Density Parity-Check (LDPC)) codes, we will introduce a new code construction, called Chained Gallager codes. Following Gallager’s method we will derive a lower bound on the normalized minimum distance for the ensemble of Chained Gallager codes. Applying this lower bound on the normalized minimum distance to different transmissions schemes with
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Purpose The aim of this paper is to provide insights into, and perspectives on, the transformation of mindsets for logisticians. We argue that by exploring paradoxes inherent in the efficiency-focused paradigm of today, a strategic mindset can emerge in which central logistics management issues can be addressed, understood, and dealt with in order to enhance supply chain effectiveness and innovati
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Abstract PURPOSE: Longitudinal prospective study before, during and after normal pregnancy of the effect of short-term submaximal exercise on maternal oxygen saturation. METHODS: Fourteen healthy women were recruited to the study before a planned pregnancy, and were followed seven times during the pregnancy and for up to 6 month after delivery. A submaximal bicycle exercise test with a target hea
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Since 1989, the authors have given courses in research methodology, and these courses are now given at six venues in southern Sweden, as well as in Denmark. The course corresponds to half a year's full-time study, with half the time devoted to lectures and studies of literature, while the rest is spent on an individual project under supervision. To enable part-time study, the course extends over 1
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Attribute grammars are useful in integrated editing environments for obtaining automatic incremental compilation features. However, traditional attribute grammars use aggregated values during name resolution, resulting in large sets of affected attribute instances after edits. In this paper, we show how reference attribute grammars (RAGs) can significantly reduce the number of affected attributes.
