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LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase fa

Vertebral fractures are associated with back pain and disability. There are, however, few prospective data looking at back pain and disability following identification of radiographic vertebral fracture. The aim of this analysis was to determine the impact of radiographically identified vertebral fracture on the subsequent occurrence of back pain and disability. Women aged 50 years and over were r

Laboratory and field experiments were used to investigate how different marking procedures, with 23 mm PIT (passive integrated transponders) – tags, affected mortality, body condition and tag expulsion in small roach Rutilus rutilus and rudd Scardinus erythrophthalmus (117 to 163 mm total length). In a laboratory experiment mortality was low (≤ 6%) and only occurred among fishes that had their inc

Aim: Examine the effect of a 10 h intervention programme compared with post-mailed minimal intervention (PMMI) given to high-risk alcohol-drinking university freshmen in a random design. Method: In total 693 freshmen at the Lund Institute of Technology, Lund University, Sweden were included in the study. A cognitive behavioural alcohol program (CBAP) or PMMI was given to high-risk drinking freshme

Light-harvesting in fucoxanthin-chlorophyll protein (FCP) of diatoms is performed by a cluster of chromophores: chlorophylls a (Chl a), chlorophylls c(2) (Chl c(2)), and carotenoids fucoxanthins. It is well-known that energy captured by fucoxanthin is transferred to Chl a on a subpicosecond time scale. However, the energy flow channel connecting Chl c(2) and Chl a remained elusive. In this study,

The aim of this study was to explore the variation and regulation of bacterial carbon processing at a coastal oligotrophic site of the Island of Majorca in the Mediterranean Sea. In situ bacterial production (BP), respiration (BR), growth efficiency, and carbon demand in relation to environmental parameters were studied over an annual cycle. In addition, the response of bacterial carbon processing

Introduction: The incidence of hyperthyroidism has been reported in various countries to be 23-93/100000 inhabitants per year. This extended study has evaluated the incidence for similar to 40% of the Swedish population of 9 million inhabitants. Sweden is considered to be iodine sufficient country. Methods:All patients including children, who were newly diagnosed with overt hyperthyroidism in the

to evaluate the clinical outcomes after fenestrated endovascular aortic aneurysm repair (F-EVAR) in octogenarians.

Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering strategy, where hypoglycemia may be a limitation for the therapy and also a factor underlying clinical inertia. Glucose-lowering medications that increase circulating insulin in a glucose-independent manner, such as insulin and sulfonylurea therapy, are the most comm

We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A total of 218 individuals, recruited from centres in Norway, Sweden and the UK were included in this study; 121 with clinically or neuropathologically diagnosed DLB/PDD and 97 age-matched, cog

Several investigations have revealed surprisingly high activities during the winter in vegetation and soil in temperate and subarctic areas. Plants have been found to photosynthesize even under snow cover and at temperatures below freezing, and decomposer microorganisms can function, at low rates, all year around. In temperate grasslands, the vegetation includes winter annual herbs as well as bryo

Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine

To examine if overall diet quality is associated with cellular and soluble biomarkers of systemic inflammation in middle-aged individuals.

Results of useful exergy accounting at the societal (i.e. national or global) level are potentially important for policy purposes, such as the development of energy or GHG emission scenarios, and the determination of the major energy inefficiencies (and thus improvement potentials) within a country. However, useful exergy societal studies commonly differ in their accounting methodology, which affe