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AIM: To describe spontaneously reported cases of torsades de pointes (TdP) in Sweden and to investigate if this adverse drug reaction (ADR) was labelled in the summary of product characteristics (SPC) for the drugs implicated. METHODS: Reported cases of TdP 1991-2006 were identified and evaluated with regard to drug use and other possible risk factor. RESULTS: Among a total of 61 788 ADRs, 88 case
Sacrococcygeal teratoma (SCT) is a rare congenital tumor associated with high rates of perinatal mortality and morbidity. This study evaluated the incidence, prenatal detection rate, and early predictors of a complicated outcome following diagnosis of SCT.
This study reports the Swedish construct validation of two translated attachment style scales. The factor structure of the attachment construct was investigated via exploratory and confirmatory factor analyses of attachment scores from 515 students of a Swedish university. Results supported the expected two-factor solution, but found a three-factor solution to be a viable alternative. In addition,
Clin Microbiol InfectAbstract Propionibacterium acnes is a common and probably underestimated cause of delayed joint prosthesis infection. Bacterial biofilm formation is central in the pathogenesis of infections related to foreign material, and P. acnes has been shown to form biofilm both in vitro and in vivo. Here, biofilm formation by 93 P. acnes isolates, either from invasive infections (n = 45
In numerous social control settings, staff routinely write case histories on clients to assist colleagues and authorities in treatment decisions. In this article, we examine how such institutional writing constructs ‘working versions’ of youngsters, portraying their objects of care as personally troublesome. Simultaneously, the institution is portrayed as facelessly, uniformly and collectively rem
A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first
In clinical practice, blood volume flow (BVF) is typically calculated assuming a perfect parabolic and axisymmetric velocity distribution. This simple approach cannot account for the complex flow configurations that are produced by vessel curvatures, pulsatility and diameter changes and, therefore, results in a poor estimation. Application of the Womersley model allows compensation for the flow di
The Peaceman--Rachford scheme is a commonly used splitting method for discretizing semilinear evolution equations, where the vector fields are given by the sum of one linear and one nonlinear dissipative operator. Typical examples of such equations are reaction-diffusion systems and the damped wave equation. In this paper we conduct a convergence analysis for the Peaceman--Rachford scheme in the s
Abstract in UndeterminedIn many industries, a national accident investigation board conducts investigations following major accidents. For safety improvements to be achieved, however, it is essential that the recommendations presented in these investigations are followed by necessary actions. In this paper, challenges related to implementation of recommendations from accident investigations are st
Purpose: We have developed a statistical prediction model for prostate cancer based on four kallikrein markers in blood: total, free, and intact prostate-specific antigen ( PSA), and kallikrein-related peptidase 2 ( hK2). Although this model accurately predicts the result of biopsy in unscreened men, its properties for men with a history of PSA screening have not been fully characterized. Experime
Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychot
The introduction of the Hausdorff alpha-entropy in Xing (2008a), Xing (2008b), Xing (2010), Xing (2011), and Xing and Ranneby (2009) has lead a series of improvements of well-known results on posterior consistency. In this paper we discuss an application of the Hausdorff a-entropy. We construct a universal prior distribution such that the corresponding posterior distribution is almost surely consi
BACKGROUND: Limited data exists of tracking and changes in accelerometer measured physical activity in children. METHODS: Physical activity was assessed by accelerometers for four days in 167 children (boys n=90, girls n=77), aged 9.8±0.6 years. Follow-up measurement was made 2.0±0.1 yrs later (range 1.9-2.1 yrs). General physical activity (GPA) was defined as mean count/minute. Minutes of inact
Protein affinity reagents (PARs), most commonly antibodies, are essential reagents for protein characterization in basic research, biotechnology, and diagnostics as well as the fastest growing class of therapeutics. Large numbers of PARs are available commercially; however, their quality is often uncertain. In addition, currently available PARs cover only a fraction of the human proteome, and thei
Emotional contagion – the alignment of emotions between individuals through behavioral synchronization – is proposed as a key, basic component of human social cognition and empathy. In the field of cognitive zoology, contagious behaviors have also received attention. Several such behaviors have been documented in various species. Nevertheless, emotional and behavioral contagion differ. Emotional c
Local treatment of metastases such as metastasectomy or radiotherapy remains controversial in the treatment of metastatic renal cell carcinoma. To investigate the benefits and harms of various local treatments, we did a systematic review of all types of comparative studies on local treatment of metastases from renal cell carcinoma in any organ. Interventions included metastasectomy, radiotherapy m
The critical features of a strategy to promote improved teaching and learning are explored in this article from a socio-cultural perspective in a research-intensive institution. The paper presents theoretical underpinnings and implications as well as an empirical case study of such a strategy and its seemingly successful results. The strategy builds on scholarship of teaching and learning beyond i
