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Advances in stem cell research and therapeutic development Review Article https://doi.org/10.1038/s41556-019-0344-z 1Center for Regenerative Medicine “Stefano Ferrari”, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy. 2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) and Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffael
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Deirdre B. Hobana,b, Shelby Shrigleya,b, Bengt Mattssona, Ludivine S. Bregerc, Ulla Jarla, Tiago Cardosoa,b , Jenny Nelander Wahlestedta,b, Kelvin C
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_5.pdf - 2026-07-08
Minnesanteckningar EDS Nordic User Group Lund 2014-05-16 Plats: Bromansalen, Lunds Universitetsbibliotek När: 2014-05-16 10-16 Närvarande: Anders Johansson (Region Skåne), Anders Söderbäck (Stockholms universitetsbibliotek), Anna Hallberg (Linnéuniversitetets bibliotek), Anneli Mindemo (Inera), Birgit Parding (Stockholms universitetsbibliotek), Britta Wallin (Lunds Universitets bibliotek), Carina
https://www.ub.lu.se/sites/ub.lu.se/files/eds_nordic_user_group_lund_20140516.pdf - 2026-07-08
INTRODUCTION: Chronic subdural haematomas (CSDHs) are one of the most common neurosurgical conditions. The goal of surgery is to alleviate symptoms and minimise the risk of symptomatic recurrences. In the past, reoperation rates as high as 20%-30% were described for CSDH recurrences. However, following the introduction of subdural drainage, reoperation rates dropped to approximately 10%. The stand
Background: As healthcare becomes increasingly complex, new methods are needed to identify weaknesses in the system that could lead to increased risk. Traditionally, the focus for patient safety is to study incident reports and adverse events, but that starting point has been contested with a new era of safety investigations: the analysis of everyday clinical work, and the resilient healthcare. Th
Following John Ruggie’s UN mandate (2005-2011) the notion of human rights due diligence (HRDD) has become widely used by policymakers, corporations, NGOs and professionals. The question is whether this HRDD concept, as developed in the UN Guiding Principles (GPs), adequately addresses the deeper causes of human rights infringements in business operations. This article provides a textual and contex
Background: Acute aortic syndrome (AAS) is a life-threatening condition reported as often misdiagnosed. Advancements in CT availability and diagnostic algorithms, including high-sensitivity troponin and D-dimer for acute coronary syndrome (ACS) and pulmonary embolism (PE), may reduce AAS misdiagnosis, but the impact remains unclear. This study evaluated the incidence, characteristics, and clinical
Background: Dietary management of phenylketonuria (PKU) focuses on restricting phenylalanine (Phe) intake. The European PKU guidelines and the PKU Dietary Handbook recommend a simplified PKU diet, allowing unrestricted consumption of many low-Phe foods, called free foods. While this approach may reduce the treatment burden for patients, its implementation varies. This study investigated practi
With increasing age, human skeletal muscles gradually decrease in volume, mainly due to a reduced number of motor units and muscle fibers, and a reduced size of type 2 fibers. As a result, progressive weakening and impaired mobility occur. High-resistance strength training is beneficial, even in the very old, and could possibly reverse some of the detrimental effects of age-related weakness. The i
Background: Selective dorsal rhizotomy (SDR) is an operation method that decreases the degree of spasticity with long-lasting beneficial effects for children with spastic diplegia. Children undergoing SDR are postoperatively in severe pain, a pain related to both the extensive surgical exposure with multilevel laminectomy and the nerve root manipulation. Various pain management strategies for chil
Archaeologists seek to analyze patterns of similarity and difference among diverse kinds of assemblages that (1) vary in the number of specimens and (2) have been characterized by standard multi-category frequency distributions. Recent developments in computer simulation methods offer marked improvements in our ability to test statistical hypotheses about variation in relative taxonomic or typolog
The transcriptional events that control T cell tolerance are still poorly understood. To investigate why tolerant T cells fail to produce interleukin (IL)-2, we analyzed the regulation of NFkappaB-mediated transcription in CD4(+) T cells after tolerance induction in vivo. We demonstrate that a predominance of p50-p50 homodimers binding to the IL-2 promoter kappaB site in tolerant T cells correlate
Purpose: To evaluate therapeutic strategies, it is essential to use biological models reflecting important aspects of the clinical situation. The aim of the present study was to compare the maximal tolerable dose of the monoclonal antibody BR96 labeled with Y-90 or Lu-177 in immunocompetent rats. Maximal tolerable dose was defined as the highest activity that allows 100% of the animals to survive
In previous studies on Supplemental Instruction (SI) relatively little attention has been paid to the “senior” students who lead the sessions. The focus in this study is on the benefits that the SI leaders gain from their SI experience. Data from one questionnaire directed at 35 students who recently completed their assignment as SI leaders, and another questionnaire directed at 20 former SI leade
