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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 114971 sökträffar

Translating Basic Research into Safe and Effective Cell-based Treatments for Respiratory Diseases

Respiratory diseases, such as chronic obstructive pulmonary disease and pulmonary fibrosis, result in severely impaired quality of life and impose significant burdens on healthcare systems worldwide. Current disease management involves pharmacologic interventions, oxygen administration, reduction of infections, and lung transplantation in advanced disease stages. An increasing understanding of mec

A Unified Framework for Real-Time Failure Handling in Robotics Using Vision-Language Models, Reactive Planner and Behavior Trees

Robotic systems often face execution failures due to unexpected obstacles, sensor errors, or environmental changes. Traditional failure recovery methods rely on predefined strategies or human intervention, making them less adaptable. This paper presents a unified failure recovery framework that combines Vision-Language Models (VLMs), a reactive planner, and Behavior Trees (BTs) to enable real-time

Integrated life cycle assessment (ILCA) approach to daylighting renovation of a sports hall considering light quality, environmental and financial aspects

Purpose – This paper concerns an integrated life cycle assessment (ILCA) comparing daylighting retrofit solutions for an existing sports hall, currently relying only on electric lighting. Daylight quality, environmental impact and financial aspects are generally independently considered, leading to suboptimal decisions when all aspects are considered together. By taking the sports hall as an examp

Phosphorus, eutrophication and the importance of scales: a place-based transdisciplinary analysis of scalar dynamics

Phosphorus-driven eutrophication of surface waters persists across Europe and Water Framework Directive (WFD) implementation is slow. Calls for better management approaches advocate for involving multiple stakeholders, considering social, ecological and technological drivers, and applying ‘multi-level’ or ‘multi-scalar’ approaches. However, multi-level approaches rarely apply ‘scales’ and ‘levels’

Computationally efficient whole-genome quantile regression at biobank scale

Genotype–phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for continuous phenotypes, is particularly well suited for detecting and characterizing heterogeneous genotype–phenotype associations. Here, we propose a computationa

Supporting sensemaking of data in healthcare: A multi-method approach

In healthcare, the ability to make sense of data is crucial for informed and responsible decision-making. However, the ongoing digitalization of healthcare and its reliance on heterogeneous forms of data has made sensemaking increasingly complex. Data is generated, presented, and used through a variety of tools, practices, and algorithmic systems, and its meaning demands careful and context-sensit

The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory

Genetics as a science has roots in studying phenotypes of relatives, but molecular approaches facilitate direct measurements of genomic variation between individuals. Agricultural and human biomedical research are both emphasizing genotype-based instruments, such as polygenic scores, but unlike in agriculture, there is an emerging consensus that family variables act nearly independently of genotyp

ECG-based detection of body position changes in ischemia monitoring

The purpose of this gaper is to analyze and detect changes in body position (BPC) during electrocardiogram (ECG) recording. These changes are often manifested as shifts in the, electrical axis and may be misclassified as ischemic changes during. ambulatory monitoring. We investigate two ECG signal processing methods for detecting BPCs. Different schemes for feature extraction are used (spatial and

An interface damage model that captures crack propagation at the microscale in cortical bone using XFEM

Reliable tools for fracture risk assessment are necessary to handle the challenge with an aging population and the increasing occurrence of bone fractures. As it is currently difficult to measure local damage parameters experimentally, computational models could be used to provide insight into how cortical bone microstructure and material properties contribute to the fracture resistance. In this s

A critical analysis of organizational transformation – PSR

Purpose: Hunter Harrison, CEO of the railroad company CSX, died on December 16, 2017. Harrison, known as the railroad transformation guru, was a controversial person. While his transformations were applauded by investors, they were also subject to significant criticism. The author changes triggered service disruptions, customer complaints and federal scrutiny. The purpose of this paper is to condu

Fishing for ways to thrive : Integrating zooarchaeology to understand subsistence strategies and their implications among Early and Middle Mesolithic southern Scandinavian foragers

The purpose of this thesis is to evaluate and deduce the varied lifeways of Early Holocene foragers in southern Scandinavia. By taking an interdisciplinary approach, zooarchaeological data have been applied to the study of different aspects of Early and Middle Mesolithic subsistence, in order to frame a discussion concerning our current understanding of culture and life in early north European soc

Evaluation of Parking Space Detection From Aerial Imagery Using Convolutional Neural Networks

Vi har försökt hjälpa vidareutvecklingen av självkörande bilar med hjälp av att identifiera och klassificera parkeringsplatser i flygbilder. Problemet har visat sig vara svårt, och kanske inte kan lösas helt med hjälp av endast maskininlärningstekniker. Det finns dock tecken på att lösningen går mot rätt riktning, då vi kan se att systemet hittar de flesta av parkeringsplatserna som finns i exemplIn this thesis, the viability of using Convolutional Neural Networks to detect parking spaces using aerial imagery has been evaluated. Three state of the art networks have been tested - YOLOv3, RetinaNet, and Mask R-CNN. A dataset of urban parking lots and corresponding annotations was generated from scratch using a custom built GUI to annotate automatically generated images of parking lots from O

Amerta Movement of Java 1986-1997 : An Asian Movement Improvisation

Amerta Movement is free bodily movement combining the wisdom of Asia with contemporary western dynamics. It is both a concept and a practice. Life is viewed in terms of flux. Based on ordinary daily movements as well as on working with awareness and attitudes, Amerta Movement employs a technique of great simplicity in attempting to gain understanding, facilitating human growth and developing poten

Pipeline break detection using pressure transient monitoring

Sudden pipe breaks occur in water transmission pipelines and distribution mains. The consequences of these breaks can be very expensive because of the service interruption, the cost of repair, and damage to surrounding property and infrastructure. The costs associated with the pipeline breaks can be reduced by minimizing the break detection and location time. This paper presents a new continuous m

Acupuncture and transcutaneous nerve stimulation in stroke rehabilitation: a randomized, controlled trial

BACKGROUND AND PURPOSE: In small trials with control groups that receive no intervention, acupuncture has been reported to improve functional outcome after stroke. We studied effects of acupuncture and transcutaneous electrical nerve stimulation on functional outcome and quality of life after stroke versus a control group that received subliminal electrostimulation. METHODS: In a multicenter rando

How childish! Queering ‘youth’ and some other of the mutual challenges of queer and education research

Queer/ed children and young people inhabit a space that seems nicely delineated by shamed biographies, fearful prospects and ignorance. In mainstream accounts, queer/ed children and young people are often un/represented through invisibility or drama, between exoticism and pity. ‘Children’ and notions of ‘the best interest of the child’ are used to dramatize and limit societal negotiations of sexua

Concomitant therapy : an outcome variable for musculoskeletal disorders? Part 2: total joint replacement in osteoarthritis trials

Interest has grown in using the requirement of total joint replacement (TJR) as a "hard" outcome measure. Limitations exist, however, in the use of such an outcome, in particular the variability in the decision to perform surgery, length of surgical waiting lists, and sensitivity to change. This special interest group is exploring ways of retaining the clinical relevance of TJR but overcoming the