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BACKGROUND: The mechanism behind the antiviral action of interferon (IFN) therapy in chronic hepatitis C virus (HCV) infection is not well understood, and, furthermore, few factors have been shown to be good predictors of a favourable response to IFN treatment in chronic HCV infection. METHODS: Freshly explanted liver cells and peripheral blood mononuclear cells (PBMC) from 80 patients with chroni

Att skriva är en sammansatt förmåga. Det är svårt att i ord formulera vad en skicklig skribents kompetens består i, och därför också svårt att undervisa i skrivande. Ett problem vid bedömning av texter är ofta att både studenter och lärare har svårt att formulera vad som gör en bra text. Här kan metatexter vara ett stöd, för både studenter och lärare. Erfarna lärare har i regel inga problem att b

The Kleva nickel-copper mineralization is situated within a gabbro-diorite intrusion on the border between the late Svecofennian rocks of the Oskarshamn-Jonkoping belt and rocks of the slightly younger Transscandinavian Igneous Belt (TIB). The sulphides present in the mafic intrusion are pyrrhotite, chalcopyrite, pentlandite and pyrite, occurring as massive mineralization, disseminations and thin,

When a manipulator interacts with objects with poorly damped oscillatory modes, undesired oscillations and bouncing may result. In this paper, we present a method for observer-based control of a rigid manipulator interacting with an environment with linear dynamics.The controller injects a desired damping into the environment dynamics, using both visual-and force sensing for stable control of the

We investigated whether exposure to heavy metal pollution affected the immune function of individuals in a free living population of a small insectivorous passerine bird, the pied flycatcher Ficedula hypoleuca. We measured humoral immune responses in two study areas: a polluted area in the vicinity of a copper smelter and a control area far from the smelter. Plasma corticosterone level and blood h

Phosphodiesterases (PDEs) include a large group of structurally related enzymes that belong to at least seven related gene families (PDEs 1-7) that differ in their primary structure, affinity for cAMP and cGMP, response to specific effectors, sensitivity to specific inhibitors, and regulatory mechanism. One characteristic of PDE3s involves their phosphorylation and activation in response to insuli

Simulations of a cumulonimbus cloud observed in the Cirrus Regional Study of Tropical Anvils and Cirrus Layers-Florida Area Cirrus Experiment (CRYSTAL-FACE) with an advanced version of the Explicit Microphysics Model (EMM) are presented. The EMM has size-resolved aerosols and predicts the time evolution of sizes, bulk densities and axial ratios of ice particles. Observations by multiple aircraft i

The death of a newborn is a complex and tragic situation, the uncertain and stressful nature of which places emotional burdens on the parents. The aim of this study was to examine and illuminate mothers' experiences and perceptions of the care given to them at neonatal clinics while facing the threat and the reality of losing their baby. METHOD: Interviews were performed, in the form of conversati

This study was conducted to explore treatment and disease-related effects on health-related quality of life (HRQoL) in patients with aggressive lymphoma, to identify predictors for impaired long-term HRQoL, and to analyze the prognostic value of pretreatment HRQoL. Ninety-five patients with aggressive lymphoma, constituting a subset of a randomized multicenter trial comparing CHOP and MACOP-B, ent

Background: Many genome-wide scans aimed at complex traits have been statistically underpowered due to small sample size. Combining data from several genome-wide screens with comparable quantitative phenotype data should improve statistical power for the localisation of genomic regions contributing to these traits. Objective: To perform a genome-wide screen for loci affecting adult stature by comb

An algorithm for the detection and location of sudden bursts in water distribution networks combining both continuous monitoring of pressure and hydraulic transient computation is presented. The approach is designed for medium and large bursts that are the result of the sudden rupture of the pipe wall or other physical element in the network and are accompanied by the transient pressure wave that

High-spin states in Kr-76(36)40 have been populated in the Ca-40 (Ca-40,4p) Kr-76 fusion-evaporation reaction at a beam energy of 165 MeV, and studied using the GAMMASPHERE and MICROBALL multi-detector arrays. The ground-state band and two signature-split negative-parity bands of Kr-76 have been extended to similar to 30h. Lifetime measurements using the Doppler-shift attenuation method indicate t

Popular Abstract in Swedish Denna studie fokuserar på distriktssköterskors hälsovägledning i barnhälsovården. Syftet med studien är att öka förståelsen för hur hälsovägledning utformas och genomförs, samt att generera teori, användbar för praktisk barnhälso-vårdsverksamhet. Data samlades in genom videoobservationer med efterföljande intervjuer, fältanteckningar, anteckningar från gruppdiskussionerChild Health Services (CHS) form a strategic arena for Swedish health promotion, from a societal as well as individual perspective. The present study focuses on district nurses´ health counselling in CHS. The aim is to improve understanding of what is important in shaping and accomplishing health promotion, and to generate theory useful in a CHS context. Data were collected at CHS in primary healt

Executive functions (EF) decline with age and this decline in older adults with generalised anxiety disorder (GAD) may be influenced by heart rate variability (HRV), brain-derived neurotrophic factor (BDNF), and physical fitness. Understanding these relationships is important for tailored treatments in this population. In this study, 51 adults with GAD (M age = 66.46, SD = 4.08) and 51 healthy con

Moisture damages lead to significant costs and impact indoor environments negatively. Identifying their occurrence patterns is crucial for the implementation of preventive or mitigative measures, though it remains highly challenging due to the complex interplay of multidimensional variables. This study aims to identify primary moisture damage profiles in Swedish buildings and evaluate their preval

The representation of expressivity of sound and colour in functional information is still a fairly unexplored field. Alternative ways of representing functional information are necessary when providing feedback in technical environments as homes, cars, nuclear power plants, and intensive care. One possible solution could be non-verbal representation of expressivity in functional information using

Aims: The aim of the study was to investigate the role of social embeddedness on and off the job in relation to remaining in non-desired workplaces (NDWs) and the development of mental health. Method: The study used questionnaire data from the Scania Public Health cohort (N=2410) that were collected in 2000 (T1), 2005 (T2) and 2010 (T3). Logistic regression models were calculated to probe how NDWs