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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 114091 sökträffar

Adsorption of lysozyme on Silica Surfaces and Specific ion effects

Biomedical application of nanoparticles is largely associated to their fate in biological media which, in fact, is related to their surface properties. Surface functionalitzation plays a key role in determining biodegradation, cytotoxicity and biodistribution through interactions which may be meditated by the macromolecules occurring in biological media. This project is focused on the effect of di

Designing transdisciplinary sustainability science : a comparative analysis of a transdisciplinary research framework and design thinking

Sustainability science has to solve some of the most complex problems of our times. So far, the field of sustainability science is more known for its promises than its solutions. It is successful at creating knowledge but is lacking in terms of developing actionable knowledge. The transdisciplinary process incorporates practitioners and the people for whom the solution is intended in the research

Imputation Methods in Dialysis Data

Vid de flesta processer som innefattar insamlande av data kan det ibland uppstå problem som gör att all data inte samlas in korrekt. När detta händer uppstår det tomma platser i datan där värden saknas. Det finns många sätt att hantera dessa tomma platser och i många fall kan man bortse från dem. Om ett komplett dataset behövs för analys kan så kallade imputationsmetoder användas för att fylla i d

(Un)knowingly needing support : an exploration into the importance of social support and relations for climate-friendly Danes

Many studies on how to encourage pro-environmental behaviour have been done. However, they have tended to focus on individual behaviour in isolation of social interactions despite increasing scepticism about the effectiveness of this approach in promoting the necessary transition toward a more sustainable society. Such a transition constitutes a central part of the transformational mode of sustain

Bakom stängda dörrar – Om rättssäkerheten i de idrottsliga dopingprocesserna

Denna uppsats, som inriktar sig på prövning av dopingrelaterade ärenden, behandlar intressekonflikten som uppstår mellan idrottsutövarens rätt till en rättvis dopingprocess och idrottens autonomi. Idrottens värld har länge valt att ha en långtgående självbestämmanderätt och de anser att autonomin är en fundamental utgångspunkt för att idrottens verksamhet ska kunna fortsätta på ett fungerande sättThis thesis deals with the conflict of interest arising between an athlete’s right to a fair trial, relating to doping, and the autonomy of sports. The world of sport has claimed a far-going autonomy for a long time. They believe that autonomy is a fundamental ground for the continuance of a well functioning world of sport. Today, the organs of the national sport organisation, Riksidrottsförbundet

What’s in it for me? Food packaging and consumer responses in a focus group study

Purpose – This study has three broad objectives: (1) to explore consumer views on different dimensions of consumer packaging when it comes to a common staple food; (2) to discuss the role of different packaging features in consumer choice; (3) to compare consumer views on purchasing a common staple food either as an undifferentiated anonymous commodity or as a differentiated product.Design/methodo

Moderate hyperkalemia in hospitalized patients with cirrhotic ascites indicates a poor prognosis

Objective. Development of ascites in patients with liver cirrhosis is an ominous sign with a poor outcome. A liver transplantation must be considered, and it then becomes important to know if there are any factors indicating a worsened prognosis. Material and methods. We used official registers for a follow-up study of at least 5 years considering the prognosis of 155 prospectively recruited in-pa

Revisiting Corporate Sustainability: Towards a Critically-Performative Research Agenda

The article discusses research which focused on the influence of Critical Management Studies (CMS) on the goals of firms to attain corporate sustainability (CS). The researchers argued that both CMS and CS share objectives that are overlapping in various ways and aim to contribute to the issue concerning how CS can be studied critically and address the problem related to the relevance of CMS-inspi

Holocene climate and environmental dynamics on the Tristan da Cunha island group, South Atlantic

Popular Abstract in Swedish Efter den senaste istiden har klimatet varit dynamiskt med både stora och snabba klimatförändringar, om än inte av samma storlek som under istiden. Hur utbredda och vilka effekter dessa klimatförändringar har haft är dock inte helt kartlagt. Målet med denna avhandling är att i detalj rekonstruera de klimat- och miljöförändringar som har påverkat ögruppen Tristan da CunhIt has been shown that the present interglacial has been climatically dynamic with both rapid and severe climatic fluctuations. The spatial and temporal differences of these changes are however not fully resolved. The aim of this thesis is to present a detail high resolution record of past climate changes from the central South Atlantic. Peat and lacustrine sediment sequences were retrieved from

Vattensänkningar : en analys av orsaker och effekter

Populärvetenskaplig sammanfattning: Grässjön ligger på kommungränsen mellan Osby och Östra Göinge, och har varit utsatt för stora förändringar på 18- och 1900-talen, bl. a. sänkningsprojekt och ändrade flöden. Sjön ingår i Tommaboda/Ekeshultsån, som är en del av Skräbeåns avrinningssystem - en av de åar som rinner ut i Hanöbukten. Grässjön var före 1909 en del av den tills då mycket större VielånThere are records of lowering of the water level in a lot of the Swedish lakes from the middle of the 1700th century. The aim was gaining more areable land to meet the needs of more food to support the expanding population. In areas with top soil which contents of clay or loam as in the southwest of Scania in southern Sweden this was proven to be a successful way expanding the total outcome of the

Högfrekventa tryckvariationer under de senaste århundradena

Populärvetenskaplig sammanfattning: Solen värmer jordytan olika mycket på olika platser dels beroende på om ytan är land, hav eller is och dels beroende på den breddgrad ytan är belägen på. Denna ojämna uppvärmning ger upphov till regionala ojämnheter i lufttrycket. Det är dessa tryckojämnheter som styr vindriktningarna i atmosfären och därmed vart alla vädersystemen rör sig. Det är alltså den ojäLong time-series of pressure measurements often have high quality because the early instruments are more or less the same as the modern ones. A time-series from Lund consisting of three daily measurements from 1780-1997 has been homogenised and is therefore suitable for analysing possible influences of the enhanced greenhouse effect. According to a two-layer model of the atmosphere one finds a shi

I tid och rum : en upplevelseanalys av Kärnan

In 2005 Gunhild Eriksdotter published Behind The Facades in which she analyses the ways of approaching historical buildings in archaeology. Eriksdotter emphasizes that the archaeology of buildings is in dire need of renewal videlicet the traditional outlook on buildings as two-dimensional objects need to change. She develops a method of analysing the spatial dimensions in a three-dimensional world

The Implementation of Transitional Justice in Post Conflict Situations: Case Study of Aceh and Papua

Armed conflict, either internationally or internally, has caused great sufferings to the victims and society as a whole. It constitutes a situation where the rule of law is absent and human rights are no longer respected. Even though various preventive endeavours have been campaigned and implemented by the international community, the occurrences of armed conflicts are still inevitable due to poli

Battling Bacterial Biofilm - antibiotic regimens targeting Grampositive pathogens in biofilm

Popular Abstract in Swedish Vår hud och våra slemhinnor är ständigt koloniserade med bakterier som lever i fredligt samspel med vår organism. Dessa bakterier tillhör vår normalflora och kan indelas i kommensaler respektive opportunistiska bakterier. Kommensalerna gagnar värden på olika sätt och orsakar inte sjukdom, till skillnad från opportunisterna som under vissa betingelser kan orsaka infektioAbstractBacteria in most environments encase themselves in a hydrated matrix of polysaccharide and protein, forming organized communities called biofilms. In the biofilm bacteria are protected against hostile environments. Biofilms are important clinically because of their persistence despite host defence and their recalcitrance to antimicrobials. This thesis presents three main findings: (i) biof

Ocular function and morphology in humans and rabbits exposed to vigabatrin medication

Vigabatrin is an antiepileptic drug that is known to cause visual field defects and retinal dysfunction measured by full-field electroretinography (ff-ERG). Underlying mechanisms have not yet been elucidated. The aims of this thesis were to investigate parameters of vigabatrin treatment; reversibility of visual dysfunction, prevalence of retinal dysfunction in children, role of drug-dose and evalu

On the Relation between Air void system parameters and Salt frost scaling

An attempt to develop a tool based on analysis of the air void system in concrete for an early assessment of salt frost scaling resistance of concrete is presented. Relations between the air void system parameters and scaling are discussed. A new technique based on the accumulated surface area of all air voids is presented. This is a short description of the project. The full report is available

Stroke and Functional Recovery - An experimental study on environmental influence and gene expression after cortical infarcts in the rat

Popular Abstract in Swedish Närmare 30.000 svenskar drabbas årligen av stroke (slaganfall). I ungefär 85 % av fallen är orsaken en blodpropp i ett av hjärnans kärl s.k. hjärninfarkt. En avstängning av blodflödet orsakar en snabbt insättande förlust av funktionen i det drabbade området, t.ex. halvsidig förlamning, bortfall av delar av synfältet liksom störning av olika högre hjärnfunktioner såsom mAbstract Stroke is the third leading cause of death in the western world, and the number one cause of disability. 85% of all strokes are ischemic. Most stroke survivors will experience recovery of function. The mechanisms behind this improvement are partly unknown, but may involve elements of both compensation and restoration. Exposure to an enriched environment (EE) that stimulates social interac

Role of the ProteinTyrosine Phosphatase SHP-I in Interleukin-6 Regulation of Prostate Cancer Cells

BACKGROUND. Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients. METHODS. Parental LNCaP c

Visualization and understanding of combustion processes using spatially and temporally resolved laser diagnostic techniques

Laser diagnostic techniques have for more than 30 years added very valuable input for a deepened understanding of combustion processes. The present paper will focus on techniques developed for visualization of important parameters with the ability to get detailed information in space and time. The paper is not meant to be a complete review of the entire research field but rather a survey with a ma