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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 192451 sökträffar

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Background: Insects often show adaptive phenotypic plasticity where environmental cues during early stages are used to produce a phenotype that matches the environment experienced by adults. Many tropical satyrine butterflies (Nymphalidae: Satyrinae) are seasonally polyphenic and produce distinct wet- and dry-season form adults, providing tight environment-phenotype matching in seasonal environmen

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The 2030 Agenda of the United Nations comprises 17 Sustainable Development Goals (SDGs) and 169 sub-targets which serve as a global reference point for the transition to sustainability. The agenda acknowledges that different issues such as poverty, hunger, health, education, gender equality, environmental degradation, among others, are intertwined and can therefore only be addressed together. Impl

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Modern coding theory is based on the foundation of the sparse codes on graphs, such as the low-density parity-check (LDPC) codes, and the turbo-like codes (TCs) with component convolutional codes. The success of the LDPC codes and the TCs lies in their ability to perform low-complexity iterative message passing decoding procedures. The iterative message passing decoders that exchange messages prob

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Square Kilometer Array (SKA) is a project aimed to build the largest radio telescope in the world and it has just gotten into the construction phase. In this phase, the ability to develop and integrate software in an integration environment is crucial as it is the ability to visualize system-related information via a User Interface to rapidly verify the correctness of the system behavior and spot

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Loess deposits are the most extent continental archives of climatic- and environmental change and represent important components of local and global dust systems. Consequently, their geochemistry provides an excellent basis for studying climate oscillations on land and how these affect processes in the terrestrial system. It is, however, challenging to assess information archived in loess records

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This patient case report describes a 45-year old white unmarried man with disability pension due to schizoaffective disorder, diagnosed at the age of 24. He lives in an apartment and has housing support. Retrospectively, the patient displayed prodromal markers of a disorder within the schizophrenia spectrum many years before the onset of frank psychosis, indeed since childhood. Over the years seve

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Solar access describes the amount and distribution of sunlight in living environments. Access to sunlight is crucial for the health and sustainability of cities. It is vital for people and vegetation, and for energy production and conservation. The amount of sunlight entering the city space is restricted by the urban layout, as buildings obstruct solar access by shading each other and the surround

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Artificial intelligence (AI) is a key enabler for future 6G networks. Currently, related architecture works propose AI-based applications and network services that are dedicated to specific tasks (e.g., improving the performance of RAN with AI). These proposed architectures offer a unique way to collect data, process it, and extract features from data for each AI-based application. However, this d

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INTRODUCTION: Primary familial brain calcification (PFBC) is a neurodegenerative disease characterised by bilateral calcification in the brain, especially in the basal ganglia, leading to neurological and neuropsychiatric manifestations. White matter hyperintensities (WMH) have been described in patients with PFBC and pathogenic variants in the gene for platelet-derived growth factor beta polypept

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Retinitis Pigmentosa represents a group of genetic disorders that cause progressive vision loss via degeneration of pho8toreceptors, but there is in principle no treatment available. For any therapy development, a deeper comprehension of the dis9ease-leading mechanism(s) at the molecular level is needed. Here we focused on the cGMP-PKG system, which has been suggested10 to be a driver in several m

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Introduction: The purpose of this study was to investigate neurological disorder as a risk factor for dislocation following arthroplasty for acute hip fractures. We also analysed medical and surgical adverse events (AE), readmission, reoperation, revision, and mortality as secondary outcomes. Methods: A longitudinal cohort study using prospectively collected and aggregated data from the Swedish Hi

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A precise U–Pb baddeleyite age (2251 ± 4 Ma) has been obtained for an ENE-trending dyke exposed near the Chhura region of the Bastar craton, and additional dykes of similar trend are also reported from other parts of the northern Bastar craton such as in the Dongergarh and Pakhanjore areas. We propose a new widespread ENE-trending ca. 2.25 Ga Chhura mafic dyke swarm in the Bastar craton, which rep

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Human liver glycerol 3-phosphate dehydrogenase ( hlGPDH) catalyzes the reduction of dihydroxyacetone phosphate (DHAP) to form glycerol 3-phosphate, using the binding energy associated with the nonreacting phosphodianion of the substrate to properly orient the enzyme-substrate complex within the active site. Herein, we report the crystal structures for unliganded, binary E·NAD, and ternary E·NAD·DH

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OBJECTIVES: Telehealth, the provision of healthcare through digital communication, has been proposed as a potential solution to meet the increasing demand for healthcare, particularly in the setting of the COVID-19 pandemic. Sweden has an established national telehealth service for triage and referral by phone (1177) since 2013 which has the potential to meet this increasing demand. However, littl