Filtyp
In order to achieve environmental goals, the impact of the European building stock on the environment needs to be reduced through renovation measures. However, regarding heritage buildings, the choice of measure(s) must simultaneously consider the preservation of cultural and historical values. Besides the impact on such values, energy-efficiency measures can result in increased risks for moisture
Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment inter
Background: Children with down syndrome (DS) are breastfed to a lesser extent than infants in general, despite research showing that it is possible for these children to breastfeed successfully. Aim: The aim was to describe how mothers of children with DS experienced breastfeeding and breastfeeding support from healthcare professionals. Method: A qualitative study with an inductive approach. Indiv
Background: The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although several studies have identified thrombomodulin gene (THBD) variants among venous thromboembolism (VTE) patients, the role of THBD in relation to VTE in humans remains to be clarified. Objectives: This study aimed to determine the thrombotic risk of rare and common THBD variants in a larg
Two phosphite sialyl donors, each having an auxiliary 3-(S)-phenylseleno group, were prepared and evaluated. The phenylseleno group was introduced via a new mode of generating phenylselenenic acid (‘PhSeOH’). Although the sialyl donors provided fair yields (32–76%) of the desired sialosides in glycosylations of the reactive acceptor 1,2;3,4-di-O-isopropylidene-α-d-galactopyranose, no sialylated pr
The aggregation of the amyloid β (Aβ) peptide is one of the molecular hallmarks of Alzheimer’s disease (AD). Although Aβ deposits have mostly been observed extracellularly, various studies have also reported the presence of intracellular Aβ assemblies. Because these intracellular Aβ aggregates might play a role in the onset and progression of AD, it is important to investigate their possible origi
Background: The purpose of this study is to determine the prevalence and morbidity of neck pain with or without cervical rhizopathy, upper extremity motor deficit and/or thoracolumbar pain in elderly men. Methods: We conducted a cross-sectional questionnaire study of 3,000 community-dwelling older men with a mean age of 75.4 ± 3.2 years (range 69–81) to determine if they had experienced neck pain
Quantifying air-borne and structure-borne sound insulation is an important design consideration for the indoor comfort in a building. Although sound insulation performance is commonly measured experimentally, numerical methods can have time-saving and economic benefits. Further, numerical methods can be incorporated within building simulations to provide an estimate of the acoustic environment. In
Teacher shortage and turnover is a growing problem in Sweden, yet little is known about the organisational factors associated with these problems. The current study explores teachers’ experiences of organisational processes and aims to identify relevant job demands and resources linked to professional sustainability for teachers. In this study, semi-structured focus group-interviews were conducted
Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly understood. Here, we present a novel murine KMT2A::AFF1 model, that provides key insights into KMT2A::AFF1 pre-leukemia, relevant to human dis
Hydrogen energy technologies are anticipated to play a fundamental role in securing a decarbonised energy future. While the deployment of low-carbon hydrogen energy systems remains nascent and is subject to a range of techno-economic constraints, potential scalability will also hinge on social acceptance. In response, this study draws on extensive national survey data to derive a comprehensive typ
Wheat (Triticum aestivum L.) is a major crop grown on all continents. Due to environmental concerns, it is desirable to reduce the inputs of both chemical pesticides and inorganic fertilizers. However, yield reduction must be expected when switching to low-input systems. To mitigate such losses, the use of natural or introduced microbiomes may provide the key to maintaining sustainable yield. Phyl
AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel
Allergic contact dermatitis (ACD) is a prevalent inflammatory skin condition triggered by allergens such as 2-methyl-4-isothiazolin-3-one (MI), a common preservative. The incidence of contact allergy to MI has fallen in Europe in recent years, attributable to government regulation limiting concentrations of MI I; however, incidence continues to rise in the USA. The pattern and extent of distributi
