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Aim: Crohn's anal fistula (CAF) is a complex condition, with no agreement on which patient characteristics should be routinely reported in studies. The aim of this study was to develop a core descriptor set of key patient characteristics for reporting in all CAF research. Method: Candidate descriptors were generated from published literature and stakeholder suggestions. Colorectal surgeons, gastro
The functionalised metal-organic framework MIL-101(Cr)-NH2, containing 2-aminobenzene-1,4-dicarboxylate as the linker, has been synthesised. A new tandem post-synthetic modification strategy involving diazotisation as the first step has been developed and used to introduce halo- and azo dye-functional groups into the pores.
Cryogels with interconnected channels allow high flow-through properties and mass transfer when dealing with complex mixtures such as non-clarified crude extracts. However, their mechanical strength can be challenged due to a large void volume inside the polymeric network. We have addressed this problem by forming a double-layer cryogel applied as a dye-affinity chromatography gel. In this study,
The diagnosis of peripheral arterial disease (PAD) is not always evident as symptoms and signs may show great variation. As all grades of PAD are linked to both an increased risk for cardiovascular complications and adverse limb events, awareness of the condition and knowledge about diagnostic measures, prevention and treatment is crucial. This article presents in a condensed form information on P
OBJECTIVE: To report population-based clinical presentation and outcomes in patients with urosymphyseal fistula (USF) after pelvic radiotherapy (RT). PATIENTS AND METHODS: A retrospective chart review was performed in 33 consecutive patients diagnosed with suspicion of USF in a tertial referral center from 2014-2022 to ascertain information about diagnostic delay, clinical presentation, precipitat
CP4 3HDM is a three-Higgs-doublet model based on the CP symmetry of order 4 (CP4). Imposing CP4 leads to remarkable connections between the scalar and Yukawa sectors and unavoidably generates tree-level flavor-changing neutral couplings (FCNC). It remains unclear whether FCNC can be sufficiently suppressed in the CP4 3HDM. In this paper, we systematically explore this issue. We first develop an ef
Background: Selection pressure exerted by pathogens can influence patterns of genetic diversity in the host. In the immune system especially, numerous genes encode proteins involved in antagonistic interactions with pathogens, paving the way for coevolution that results in increased genetic diversity as a consequence of balancing selection. The complement system is a key component of innate immuni
Forced cross-border migration and entrepreneurship have persisted as perennial themes throughout the annals of human history. However, the recent ‘refugee crisis’ has sparked a resurgence of interest in their interplay under the rubric of ‘refugee entrepreneurship’. While its territory is not entirely uncharted, a surge in scholarly urgency and heightened scientific production have significantly e
This paper explores the emergence of micro-level creative tensions and their interplay within collaborative innovation projects. Our findings demonstrate how, at the microlevel, an evolving set of actors, activities and artifacts support collaborative innovation in science-based SMEs. Our analysis highlights how activities and artifacts are linked through creative tensions emerging from situations
Today we depend on data based services, for example in logistics, at warehouses, and accounting services. When a data based service is delayed it can depend on its servers being overloaded, leading to economic losses. To prevent this, it is necessary to have appropriate monitoring tools that can make the system administrators aware of when performance thresholds have been breached and servers are
Biohydrogen is increasingly being explored as part of strategies to achieve deep emission reductions. While much research has focused on the technical dimension of biohydrogen, fewer efforts have positioned it in larger contexts. Using literature and expert interviews, this study applies the multi-level perspective to explore an introduction of biohydrogen to the Swedish energy system. The finding
This is a comparative study of several widespread and canonical texts from the lowlands of the Middle East and North Africa, with regard to historically reoccurring interconnected traits of ideal state structure among cultures, where Semitic languages have been main languages of communication from the 18th century BC to the modern day. The study is of reoccurring ideals of state structure with def
Abstract Zoos have been gaining increased popularity from tourists in recent years, as many people feel distant from wildlife and thus are eager to experience closeness with animals. The aim of this paper is to analyse tourist experiences of modern zoo tourism and the research question asked is “What types of tourist experiences are tourists gaining when visiting a modern zoo?” To achieve this ai
This paper empirically evaluates whether different backtests for Expected Shortfall (ES) produce similar results. In 2016, the Basel Committee on Banking Supervision proposed a shift from Value-at-Risk (VaR) to ES as the industry standard when calculating capital requirements for banks. However, ES has been found difficult to backtest. Since backtesting results form the basis for determining the c
Background In the latest years, developments in technology has created new opportunities within the area of after-sales services. Examples of such developments are the Internet of Things and Big Data, which can be used e.g. for predictive maintenance. Combined, the developments imply that there is potential gain for an OEM in using the IoT, Big Data and a transformed business model in their a
Thermoresponsive polymers with a lower critical solution temperature, LCST, have attracted interest in the development of new ``smart materials'', which change properties in response to external stimuli. Polymers with an LCST near physiological temperatures are especially relevant in biomedical applications, most notably perhaps in drug delivery systems. The aim of this work is to investi
