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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 105205 sökträffar

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OBJECTIVE: Pulse pressure (PP) is a risk marker for cardiovascular disease (CVD) in individuals 50 years and older. Inflammation is suggested to influence atherosclerosis, but could also increase PP. We aimed to examine the combined effects of PP and the inflammatory marker sialic acid, and their independent roles on CVD risk. METHODS: From a population-based study in Sweden between 1962 and 196

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The main aim of this thesis is to explore young women’s lived experience of the body, which, on one hand, is viewed as deviant – the disabled body – and, on the other hand, is viewed as accomplished – the sporting body. The questions posed in the thesis are the following: how do the young women handle the two subject positions that emerge as a result of the perception of them as respectively devia

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Neogene and Quaternary volcanic activity formed the large volume ignimbritic units (about 10 different units, namely Cappadocian ignimbritic field) around Nevşehir, Derinkuyu and Acıgöl districts. These large volume ignimbrites are mostly caldera-related products but the calderas are partially or totally buried by later pyroclastic and sedimentary cover. Source estimations for the caldera-related

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During the establishmen of an NGO Maritime Rescue Service (MRS)in the Lake Albert region in Uganda, the intelligence information management (IM) needs of the operation cere compared with earlier IM experiences of a combined peace keeping mission. This paper describes the MRS oparation IM needs. Furthermore, the Joint Command and Control Information Exchange Data Model (JC3IEDM) is introducea as th

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The level crossing method was used to measure the hyperfine structure of Bi 209 in the 6 p 2 ( 3 P 0 )6 d 2 D 3/2 and 6 p 2 ( 3 P 1 )7 s 4 P 3/2 levels of the Bi I spectrum. For the magnetic dipole and the electric quadrupole interaction constants a and b the following values were obtained: | a (6 p 2 ( 3 P 0 ) 6 d 2 D 3/2 )| = 128.0(0.6) g J /-0.79 MHz | b (6 p 2 ( 3 P 0 ) 6 d 2 D 3/2 )| = 58(4)

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Since Solow (Q J Econ 70:65-94, 1956) the economic literature has widely accepted innovation and technological progress as the central drivers of long-term economic growth. From the microeconomic perspective, this has led to the idea that the growth effects on the macroeconomic level should be reflected in greater competitiveness of the firms. Although innovation effort does not always translate i

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This paper considers university-industry relations, identifying the heterogeneity of academic knowledge with respect to economic growth and analysing its implication for the working of the academic mode of knowledge governance. It provides unique historical evidence on the differentiated effects of academic spillovers, using professorial chairs distinguished by disciplinary field, as a proxy, for

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BRCA1 mutations, although implicated in disease predisposition in a major part of the hereditary breast cancer population, do not seem to be crucially involved in tumorigenesis of sporadic breast and ovarian cancers. This suggests that tumours arising in BRCA1 mutation carriers may differ from BRCA1 negative hereditary and sporadic cancer in genetic and biological features, as well as in clinical

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BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context.METHODS: We used the comparative risk assessment

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To understand how the specialisation patterns of cities differ among scientific fields, we study patterns of knowledge production in Astrophysics, Biotechnology, Nanotechnology and Organic Chemistry in the period 1996-2012. Using keywords from journal publications, we find systematic differences across scientific fields, but remarkable similarities across cities within each field. Biotechnology sh

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This thesis is based on long-term follow-up results from two cohorts of patients with ANCA-associated vasculitis; one cohort with 535 patients originally included in 4 European randomized clinical trials (papers I and II) and one Swedish population-based cohort including 195 patients (papers III and IV). Two areas are covered in the two cohorts, respectively; the assessment of mortality, prognosti

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The 2007/08 food price crisis brought unprecedented international attention to the relationship between food and biofuels, and their competition over land. In this article we sought to understand how the international policy framing of the nexus of food, fuel and land has developed since the food price crisis. We undertook an analysis of major reports, since the crisis, by three international poli

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This paper presents a dedicated search for exotic decays of the Higgs boson to a pair of new spin-zero particles, H→ aa, where the particle a decays to b-quarks and has a mass in the range of 20–60 GeV. The search is performed in events where the Higgs boson is produced in association with a W boson, giving rise to a signature of a lepton (electron or muon), missing transverse momentum, and multip

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Modern medicine is overwhelmed by a plethora of both established risk factors and novel biomarkers for diseases. The majority of this information is expressed by probabilistic measures of association such as the odds ratio (OR) obtained by calculating differences in average "risk" between exposed and unexposed groups. However, recent research demonstrates that even ORs of considerable magnitude ar

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Type 1 diabetes can affect hippocampal function triggering cognitive impairment through unknown mechanisms. Caffeine consumption prevents hippocampal degeneration and memory dysfunction upon different insults and is also known to affect peripheral glucose metabolism. Thus we now characterized glucose transport and the neurochemical profile in the hippocampus of streptozotocin-induced diabetic rats