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Adeno-associated virus (AAV) vectors are used to deliver potentially therapeutic genes in clinical trials in Parkinson's disease (PD). Pre-existing immunity to AAV and a local neuroinflammatory response might negatively affect the efficacy of such AAV-mediated gene delivery.
Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet function, the molecular mechanisms are not yet well understood. Using RNA-sequencing, we have identified a TC
OBJECTIVE: To investigate a recently developed MRI technique for mapping the Mean Diffusivity of Tissue (MDT), which improves diffusion MRI imaging of the cerebral cortex by reducing partial volume effects from cerebrospinal fluid (CSF). As cortical lesions are common in patients with focal epilepsy, we explored the clinical value of MDT imaging in patients with drug resistant epilepsy and low-gra
In 1887, psychical researchers Richard Hodgson and S. J. Davey published a study that revealed counterintuitive aspects of human cognition: How healthy, sober, honest observers of events can be prone to seemingly remarkable errors of eyewitness testimony. Their report, titled ‘The Possibilities of Mal-Observation and Lapse of Memory from a Practical Point of View’ included a collection of eyewitne
Background. Seeking to clarify the parent-offspring transmission of Major Depression (MD) and type I Bipolar Disorder (BD), we examined offspring MD and BD risk in five informative parental pairs: Unaffected x MD, Unaffected x BD, MDxMD, MDxBD and BDxBD. Methods. We identified 289,637 individuals born in Sweden 1970-1990, followed through 2018, from parents with MD and/or BD identified from Swedis
The dominant narrative on equity, diversity, and inclusion in U.S. medical research emphasises the underrepresentation of Black and Hispanic participants in clinical trials, largely based on therapeutic phase 2 and 3 trials. Far less attention has been paid to phase 1 trials—particularly those involving healthy volunteers who assume health risks without therapeutic benefit, often for money. Focusi
This Further engagement article takes up Blok and Jensen's recent call, made through a Dialogues in Sociology Forum, to ‘invent around’ the work of Bruno Latour to highlight his continued relevance and contribution to the practice of sociology. It is proposed that one way in which Latour might be usefully invented around is by bringing his work, particularly on matters of concern, into greater rel
Given the assumptions of rational choice, this essay explicates the distributive consequences of different ethical positions and how the relationship between eth-ics and distributions provides a rationale for a struggle for moral authority for the purpose of procuring distributive shares. The argument provides a partial answer to the question of why there is political struggle in all human societi
This is a thesis on women's right to reproductive choice and the implementation of this right on the Indonesian island of Lombok. As this is a graduate thesis on the Master Program in Human Rights Law, the point of departure is the regulation of the right to reproductive choice in international human rights law. To establish the content and scope of the right to reproductive choice, the materi
This study contributes to existing theory by underlining that product brands do have a gender. In addition, the results of this study show that the need for product gender congruence is minimized in Generation Y. Therefore, rethinking the traditional gender stereotyping of products may have more consumer appeal by being marketed to both sexes, or at least to emphasize more of the products attribut
This study aims to describe how pupils' achievement scores can be affected by the school that the pupil goes to and the pupil's well-being. The participants in this study were upper secondary school pupils. The participants were doing their last year in upper secondary school and they are pupils that have reached the age of 18 years. Questionnaires were used for this study. This method ent
Biomarkers are crucial for decisions regarding adjuvant therapy in primary breast cancer, and their correct assessment is therefore of the utmost importance.
Purpose of the Study: To identify risk factors for early nursing home placement (NHP) in Alzheimer's disease (AD), focusing on the impact of longitudinal change in cognition, activities of daily living (ADL), service utilization, and cholinesterase inhibitor treatment (ChEI). DESIGN AND METHODS: In an open, 3-year, prospective, multicenter study in a routine clinical setting, 880 AD patients were
Objective: The aim of this article is to present the Swedish and Norwegian Testicular Cancer Group (SWENOTECA), with an emphasis on the history of SWENOTECA, organization, results and current status. Materials and methods: SWENOTECA was founded in 1981 as a binational organization open to hospitals in Sweden and Norway treating testicular cancer. It has since published treatment protocols for test
Despite a lack of randomized trials in comatose survivors of out-of-hospital cardiac arrest (OHCA) with an initial non-shockable rhythm (NSR), guidelines recommend induced hypothermia to be considered in these patients. We assessed the effect on outcome of two levels of induced hypothermia in comatose patient resuscitated from NSR.
Objective: Safety data regarding the usage of etoricoxib and other nonsteroidal anti-inflammatory drugs (NSAIDs) in ankylosing spondylitis (AS) and other spondyloarthritis (SpA) patients are rather limited. To estimate and compare rates of gastrointestinal, renovascular, and cardiovascular adverse events in patients exposed to etoricoxib, celecoxib, non-selective NSAIDs (nsNSAIDs) or totally unexp
PURPOSE: The aim of the study was to investigate how a diet high in dietary fiber, with several fiber sources included, modulates glucose and lipid metabolism and the inflammatory response in humans. METHODS: Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a BMI of 26.6 (0.5) kg/m(2) and a total cholesterol (TC) of 5.8 (0.1) mmol/L (mean and SEM) were given a high fiber (HF) and low fib
A multifunctional diet (MFD) was previously shown to reduce blood lipids, CRP and blood pressure in a 4-week intervention under weight-maintenance conditions. Here, MFD effects were evaluated in an 8-week intervention with no restriction for weight changes.
