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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 192604 sökträffar

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X-rays allow to non-destructively investigate biological, chemical or physical processes at thenano-scale. Their high penetration depth in matter allows to investigate samples even in-side sample environments, which would be difficult with complementary methods such astransmission electron microscopy (TEM). The microscopy technique ptychography has beenestablished in X-rayX-rays allow to non-destructively investigate biological, chemical or physical processes at the nano-scale. Their high penetration depth in matter allows to investigate samples even inside sample environments, which would be difficult with complementary methods such as transmission electron microscopy (TEM). The microscopy technique ptychography has been established in X-ray imaging in recent year

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This master thesis presents the development of a vision-based feedback control system for automating sample placement in a virtual neutron beam emulated using a laser. The thesis was carried out on behalf of the European Spallation Source (ESS) to investigate the feasibility, possibilities and limitations of using a robotic automation system for sample alignment. Due to the radioactive research en

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In this paper a multimodal optical-resolution photoacoustic and fluorescence microscope in frequency domain is presented. Photoacoustic waves and modulated fluorescence are generated in chromophores by using a modulated diode laser. The photoacoustic waves, recorded with a hydrophone, and the fluorescence signals, acquired with an avalanche photodiode, are simultaneously measured using a lock-in t

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1. Motivation, specific objectiveTo evaluate the first prototype of a home lighting system, we used a full-scale model of a studio apartment in the laboratory of the School of Architecture at Lund University. The personalised home lighting system is based on LEDs, wearable sensors and a mobile phone app to produce lighting tailored to the individual’s needs. Drawing on participant interviews (n =

Bröst- och ovarialcancer

Bröstcancer är den vanligaste cancerformen bland kvinnor. Ovarialcancer upptäcks ofta sent och prognosen är därför dålig. Den relativa 5-årsöverlevnaden är mindre än 50%, jämfört med >80% för bröstcancer. Den idag rådande uppfattningen är att det som kallas ovarialcancer i själva verket är olika sjukdomar, med skillnader i var de uppkommer, vilka egenskaper de har och hur de svarar på behandling. Breast and ovarian cancers are complex and heterogeneous, and share several features, including genetic predisposition caused by BRCA1/2 mutations. Ovarian cancer is however associated with poor survival relative to breast cancer. Utilizing comprehensive biobanks, high-throughput omics methods and in vitro model systems we aim to advance our understanding of tumour evolution, disease heterogeneity

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A compact fluorosensor with a fiber-optic measurement probe was developed, employing a continuous-wave violet diode laser as an exciting source and an integrated digital spectrometer for the monitoring of fluorescence signatures. The system has the dimensions 22x13x8 cm(3), and features 5 nm spectral resolution and an excellent detectivity. Results from measurements on vegetation and human premali

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Abstract Background. Clinical treatment with radionuclides is usually preceded by biokinetic and dosimetry studies in small animals. Evaluation of the therapeutic efficacy is essential and must rely on accurate dosimetry, which in turn must be based on a realistic geometrical model that properly describes the transport of radiation. It is also important to include the source distribution in the do

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A new method has been investigated for the mapping of dose distributions in three dimensions delivered by the Leksell gamma knife. The irradiation unit is used to selectively treat small volumes in the brain with single high doses of ionising radiation--a treatment procedure known as radiosurgery. The dosimetry method investigated utilises a dosimeter gel consisting of ferrous sulphate solution an

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The strong process forces arising during high-speed machining operations, combined with the limited stiffness of industrial robots, have hampered the usage of industrial robots in high-end milling tasks. However, since such manipulators may offer flexible and cost-effective machining solutions, a three-dimensional piezo-actuated compensation mechanism, which aims to compensate for the positioning

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Finding objective methods for assessing the performance of time–frequency distributions (TFD) of measured multi-component signals is not trivial. An optimal TFD should have well resolved signal components (auto-terms) and well suppressed cross-terms. This paper presents a novel signal adaptive method, which is shown to have better performance than the existing method, of automatically detecting th

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We have developed a dual-focus coherent anti-Stokes Raman scattering (CARS) microscope based on a dual output, compact fiber laser source. The underlying concepts of time-multiplexed, two-beam scanning and demultiplexed detection that we already employed for second-harmonic generation are here naturally extended for CARS microscopy. The layout of a robust, all-fiber laser source was reconfigured t

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With the evolving technology of mobile electronics and other forms of communication methods, an increasing demand of speech intelligibility is introduced. In a conference room for example, multiple microphones are placed directly in front of the speaker in order to pick up clean speech. However, several challenges still exist. For instance the distance between speaker and microphone will not be fi

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Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4-vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base-labile carbonate ester bond was easily hydrolyzed