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Bradykinin (BK) and bombesin (BN) stimulate an increase in the tyrosine phosphorylation of a 120-kDa group of proteins (pps120) in Swiss 3T3 cells (Leeb-Lundberg, L. M. F., and Song X.-H. (1991) J. Biol. Chem. 266, 7746-7749). Here, we show that a component of pps120, p125, was specifically immunoprecipitated with antibodies against the p21ras GTPase-activating protein (GAP). The major portion of
There is a demand for a more fluent and more efficient traffic. This can be achieved through more intelligent traffic light control. This thesis presents theory and an application in which people are tracked and their intentions to cross a crosswalk is predicted with a novel prediction algorithm based on Markov theory. The background segmentation and tracking algorithms was based on already known
ABSTRACT Background: Prediabetes is a global epidemic with rising prevalence rates, but its diagnosis based on traditional risk factors is challenging. Application of novel machine-intelligence based methods to public health databases could provide valuable insights into the disease process. Aim: To build predictive models to elucidate the determinants of prediabetes using machine learning algorit
Här har vi samlat kontaktuppgifter till aktuella forskare och experter med specialkompetenser utifrån olika aspekter inom klimat- och hållbarhetsområdet. Du hittar även länkar till forskarnas sidor i universitetets forskningsportal. Biologisk mångfald och ekosystemtjänster Genväg till experter per ämnesområde/rubrik:Biologisk mångfaldJordbrukSkogUrban biodiversitet Biologisk mångfaldÅke Lindström
The structural basis for the biological specificity of human cystatin C has been investigated. Cystatin C and other inhibitors belonging to family 2 of the cystatin superfamily interact reversibly with target peptidases, seemingly by independent affinity contributions from a wedge-shaped binding region built from two loop-forming inhibitor segments and a binding region corresponding to the N-termi
In women with rheumatoid arthritis (RA) it has been observed that during pregnancy a majority of patients experience amelioration, but after delivery a relapse of the disease is common. However, there are few studies, with diverging results, addressing the effect of parity on the severity of RA over time. Our aim was to explore the impact of parity, with stratification for anti-citrullinated prote
Cytochromes function in electron transfer reactions, e.g. in respiratory systems, and contain haem as a prosthetic group. Cytochromes of the c-type differ from other cytochromes in that haem is covalently attached, via thioether linkages, to two cysteine residues in a conserved sequence motif in the protein, Cys-Xaa-Yaa-Cys-His. The functional location of c-type cytochromes in bacteria is on the o
We tested 74 passerine microsatellite loci for cross-amplification in the Principe seedeater (Serinus rufobrunneus), and identified 15 loci that were both polymorphic and easy to score. In a sample of 113 individuals, the number of alleles ranged between three and 71. Three loci deviated from Hardy-Weinberg equilibrium after correcting for multiple tests, and one locus had high estimated null alle
Inactivation of factor Va (FVa) by activated protein C (APC) is a key reaction in the down- regulation of thrombin formation. FVa inactivation by APC is correlated with a loss of FXa cofactor activity as a result of three proteolytic cleavages in the FVa heavy chain at Arg(306), Arg(506), and Arg(679). Recently, we have shown that heparin specifically inhibits the APC- mediated cleavage at Arg(506
Drugs that antagonize D2-like receptors are effective antipsychotics, but the debilitating movement disorder side effects associated with these drugs cannot be dissociated from dopamine receptor blockade. The "atypical" antipsychotics have a lower propensity to cause extrapyramidal symptoms (EPS), but the molecular basis for this is not fully understood nor is the impact of inverse agonism upon th
Acute myeloid leukemia (AML) is a fatal disease that is characterized by a rapid expansion of myeloid leukemic blasts with impaired differentiation that accumulate in the bone marrow. The prognosis for AML is generally poor, with a five-year overall survival of around 20% in patients over 60 years old. Current AML treatment strategies, including chemotherapy and hemapoietic stem cell trasplantatio
Nocturnal lepidopteran pollinators face pesticide exposure risks in agricultural landscapes, yet lack adequate risk assessment frameworks compared to diurnal species. We present a formal model description for Noctua pronuba within the Animal Landscape and Man Simulation System (ALMaSS), providing the first comprehensive agent-based framework for assessing the impacts of pesticides on nocturnal mot
Neuropeptide Y (NPY-(1-36)) acts on Y1 and Y2 receptors at the sympathetic neuroeffector junction. Various truncated NPY analogs were tested in the isolated guinea-pig caval vein where NPY is a vasoconstrictor (Y1 receptors) and in isolated rat vas deferens, by monitoring the suppression of electrically evoked contractions (Y2 receptors). The aim of this study was to define which parts of the NPY-
Background: Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within p
We demonstrate that a Ni-Mn oxide partially inverted spinel (Ni1-pMnv)[NivMn2-v]O-4 having inversion degree v approximate to 0.8 and produced by a modified polymeric precursor method exhibits behaviour previously reported only in monophased samples. The structure of the specimen was determined using Rietveld analysis of X-ray and neutron powder diffraction data, showing that at room temperature th
