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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 193287 sökträffar

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BACKGROUND: Viral shedding and neutralizing antibody (NAb) dynamics among patients hospitalized with severe coronavirus disease 2019 (COVID-19) and immune correlates of protection have been key questions throughout the pandemic. We investigated the duration of reverse transcriptase-polymerase chain reaction (RT-PCR) positivity, infectious viral shedding and NAb titers as well as the association be

Hållbarhetsveckan fyller 10 år!

18 april 2026 11:00 till 14:00 | Event I år fyller Hållbarhetsveckan 10 år och det firar vi med kalas under Familjeaktiviteterna i Botaniska trädgården! 10 år av att belysa och diskutera hållbarhetsfrågor tillsammans med Lunds universitet, Lunds kommun, studenter och Lundabor - det måste firas!Som del av Familjeaktiviteterna i Botaniska trädgården under Hållbarhetsveckans 2026 sista dag bjuder vi

https://www.lu.se/evenemang/hallbarhetsveckan-fyller-10-ar - 2026-07-18

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Background Smoking is a risk factor for the development of anti -citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA). Whether smoking predisposes to severe joint damage progression is not known, since deleterious, protective and neutral observations have been made. Objective To determine the effect of smoking on joint damage progression. Methods Smoking status was assessed i

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Pancreatic cancer (PC) has a poor prognosis, with a 5-year survival of 3-4%. This is mainly due to late diagnosis because of diffuse symptoms, where 80-85% of the patients are inoperable. Consequently, early diagnosis would be of significant benefit, resulting in a potential 5-year survival of 30-40%. However, new technologies must be carefully evaluated concerning effectiveness and healthcare cos

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Purpose: The aim of this study was to compare the diagnostic performance of the three software packages 4DMSPECT (4DM), Emory Cardiac Toolbox (ECTb), and Cedars Quantitative Perfusion SPECT (QPS) for quantification of myocardial perfusion scintigram (MPS) using a large group of consecutive patients. Methods: We studied 1,052 consecutive patients who underwent 2-day stress/rest 99mTc-sestamibi MPS

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Adipic acid is an industrially important dicarboxylic acid and an essential precursor in the synthesis of Nylon-6,6. Due to the environmental impact associated with the current synthetic methods for Nylon-6,6 production, greener alternatives based on renewable and bio-based feedstocks are needed. In the present study, the potential of two Pseudomonas putida strains engineered for muconic acid

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Avian haemosporidian parasites are useful model organisms to study the ecology and evolution of parasite-host interactions due to their global distribution and extensive biodiversity. Detection of these parasites has evolved from microscopic examination to PCR-based methods, with the mitochondrial cytochrome b gene serving as barcoding region. However, standard PCR protocols used for screening and

Harmony Automatism

18 mars 2026 18:00 till 21:00 | Konsert, Övrigt "Dream Protocol" merges live performance with immersive sound and video installation, exploring automatism, improvisation, dreams, and the subconscious. Handwritten scores serve as a starting point, translated into sound and visual compositions that integrate grand piano, flute, vocals, electronics, and dream-inspired textual material. Music is compo

https://www.lu.se/evenemang/harmony-automatism-eva-siden-irene-gellein - 2026-07-18

Kulturnatten på Ekonomihögskolan: Vem styr – du eller AI?

20 september 2025 15:30 till 19:00 | Föreläsning Välkommen till Ekonomihögskolan under Kulturnatten! Ta del av ett program som belyser aktuella frågor om AI och digitalisering. Våra forskare inom handelsrätt, marknadsföring och informatik ger dig insikter i hur artificiell intelligens påverkar dig som konsument och även samhället i stort. Dessutom bjuder vi in till bokbord med litteratur från hela

https://www.lu.se/evenemang/kulturnatten-pa-ekonomihogskolan-vem-styr-du-eller-ai - 2026-07-18

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Bifidobacterium bifidum 791 (commercially available as B. bifidum BIM B-733D) cell-surface biopolymers (BPs) interact selectively with human serum thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies (anti-TPO and anti-Tg, respectively). BPanti-TPO and BPanti-Tg were isolated from the soluble fraction of B. bifidum BIM B-733D by affinity chromatography with anti-TPO or anti-Tg, respectiv

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Protein HC (human complex-forming glycoprotein, heterogeneous in charge) is a member of the lipocalin superfamily of hydrophobic ligand-binding proteins. The quantitatively dominating blood plasma form of protein HC is a protein HC-IgA complex (HC-IgA), which is the fourth most abundant immunoglobulin species in plasma. A photodiode array detection system on-line with a high performance liquid chr

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Disease gene identification is still a challenge despite modern high-throughput methods. Many diseases are very rare or lethal and thus cannot be investigated with traditional methods. Several in silico methods have been developed but they have some limitations. We introduce a new method that combines information about protein-interaction network properties and Gene Ontology terms. Genes with high

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Using a high-throughput functional screen, the atypical L-type Ca 2+ channel blocker diltiazem was discovered to be an agonist at the human ghrelin (GHSR1a) receptor. In cellular proliferation, Ca2+ mobilization, and bioluminescence resonance energy transfer (BRET-2) assays, diltiazem was a partial agonist at GHSR1a receptors, with 50 to 80% relative efficacy compared with the GHSR1a peptide agoni

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This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H→ bb¯ , for proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy s=13 TeV. These decays are reconstructed from calorimeter jets found with the anti-ktR= 1.0 jet algorithm. To tag Higgs bosons, a combina

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The interaction between living groups A, C and G streptococci and IgG Fc was studied using human IgG, IgG Fc and IgG Fc-intermediate (Fci) fragments, chemically modified human IgG and fragment D of staphylococcal protein A (SPA). Diethylpyrocarbonate modification of His or N-acetylimidazole modification of Tyr of human IgG resulted in the loss of its capacity to inhibit the binding of radiolabelle

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N-acyl taurines (NATs) are bioactive lipids with emerging roles in glucose homeostasis and lipid metabolism. The acyl chains of hepatic and biliary NATs are enriched in polyunsaturated fatty acids (PUFAs). Dietary supplementation with a class of PUFAs, the omega-3 fatty acids, increases their cognate NATs in mice and humans. However, the synthesis pathway of the PUFA-containing NATs remains undisc

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INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.METHODS: Blood samples from the coronary sinus were obtained at th

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Zinc (Zn) is an important trace element that is essential for optimal plant growth. Zinc-solubilising bacteria can release Zn from its insoluble compounds. We isolated and identified Zn-solubilising bacteria (ZnSB) from the rhizosphere, and semi-quantitively and quantitatively evaluated their ability to dissolve various Zn minerals (ZnO, ZnCO3 and Zn3(PO4)2). Out of 24 rhizosphere soil samples, 15