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Increasing imperviousness in urban areas, and changes in rainfall intensity and return periods because of climate change increase urban flood risk. This study utilizes the hydraulic model Mike+ to assess the multifunctional use of existing roads and parking lots, which could serve to either retain or detain stormwater and accommodate trees, plants, and vegetation as part of a low-impact developmen
Scorzoneroides autumnalis is a highly polymorphic perennial with several described infraspecific taxa, largely differing in involucre colour and indumentum intensity. Here, we examine the role of ecotypic divergence and phenotypic plasticity in shaping large-scale geographical variation in these characters. We collected phenotypic data from herbarium specimens and garden-grown plants of S. autumna
Objective: To investigate (i) to what extent physiotherapists (PTs) working in stroke rehabilitation in various parts of the stroke care chain have implemented interventions according to the national guidelines for stroke (NGS), (ii) facilita-ting and hindering factors for the implementation, and (iii) differences between various care settings. Design: A cross-sectional study. Subjects: 148 PTs wo
Purpose: The apparel and textile sector poses a significant environmental challenge due to its substantial contribution to pollution in the form of air, water and soil pollution. To combat these issues, the adoption of sustainable practices is essential. This study aims to identify and analyse the barriers that hinder the progress of sustainability in the apparel and textile industry. By consultin
OBJECTIVE: The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample. METHODS: To this end, 1,244,516 offspring in intact families with a mean age at follow-up of 37.7 years (SD=6.8) were examined. Hazard ratios for offspring of parents with AUD were calculated using Cox model
Upper-body adiposity is adversely associated with metabolic health whereas the opposite is observed for the lower-body. The neck is a unique upper-body fat depot in adult humans, housing thermogenic brown adipose tissue (BAT), which is increasingly recognised to influence whole-body metabolic health. Loss of BAT, concurrent with replacement by white adipose tissue (WAT), may contribute to metaboli
Kapitlet lyfter fram frågan om mänskliga rättigheter i utvalda former och hur de påverkar migranters positioner. Ett svenskt exempel illustrerar de utmaningar som migranter står inför i termer av exkludering.
Glucagon is secreted from the pancreatic alpha cells and plays an important role in the maintenance of glucose homeostasis, by interacting with insulin. The plasma glucose levels determine whether glucagon secretion or insulin secretion is activated or inhibited. Despite its relevance, some aspects of glucagon secretion and kinetics remain unclear. To gain insight into this, we aimed to develop a
Ex vivo histology remains the gold standard against which MRI biophysical models, e.g. the MR g-ratio which characterises the fraction of a fibre’s diameter that is myelinated, are evaluated. The MR g-ratio model requires a measure of myelin density, for which magnetization transfer saturation (MT) has been used as a biomarker. However, changes occurring post mortem, e.g. autolysis, temperature ch
This document is a position statement from the Society for Cardiovascular Magnetic Resonance (SCMR) on recommendations for clinical utilization of cardiovascular magnetic resonance (CMR) in women with cardiovascular disease. The document was prepared by the SCMR Consensus Group on CMR Imaging for Female Patients with Cardiovascular Disease and endorsed by the SCMR Publications Committee and SCMR E
Background: Inherited pathogenic variants (PVs) in the CDKN2A gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the CDKN2A testing, carried out in Sweden in the years 2015-2020, was evaluated.Materials and methods: Included families had (1) three
In 1975, Sweden extended voting rights in local elections to immigrants without Swedish citizenship (resident aliens). In this essay, motives behind the reform are analysed and it is argued that these were based on a wish to speed up the integration of immigrants rather than on normative ideas about the nature of democracy. In fact, the reform was seen as a part of the emerging Swedish integration
Crowdfunding offers a new potential source of financing of sustainability initiatives and the Sustainable Development Goals (SDGs) in particular. Such funding support is potentially even more important given the impacts of COVID-19 on the global economy. However, little theoretically based work has been conducted on sustainability crowdfunding. Therefore, this study builds and tests an integrated
Risk factors for ischemic stroke is suggested to differ by etiologic subtypes. The purpose of this study was to examine the associations between modifiable and non-modifiable risk factors and atherothrombotic stroke (i.e., excluding cardioembolic stroke), and to examine if the potential benefit of modifiable lifestyle factors differs among subjects with and without predisposing comorbidities. Afte
Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur in the injured human brain and be implicated in the neurodegenerative aftermath of
The present study focuses on introducing the concept of optimisation and proposing a model, including evaluation of image quality, to be used in the clinical routines where image-guided intervention is being performed. The overall aim of the study was to develop a model for evaluating the use of imaging in X-ray-guided interventional procedures and its possible implications on optimisation of radi
The Jk(a-b-) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a-b-) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a-b-) individuals present a clinical challenge because anti-Jk3 is produced readily in response to
Here, we present a revised protocol to derive neuroepithelial stem (NES) cells from human induced pluripotent stem cells. NES cells can be further differentiated into a culture of neurons (90%) and glia (10%). We describe how to derive and maintain NES cells in culture and how to differentiate them. In addition, we show the potential use of NES cells to study the role of reactive oxygen species in
In 2018, a strategy for Sweden's first National Forest Program was launched. As part of its implementation, County Administrative Boards have initiated dialogue processes for drafting regional forest strategies. Stakeholder deliberation is ascribed the potential to promote trust and mutual understanding, lead to more robust decisions and smoother implementation. We examine the dialogue processes,
Background: Very preterm infants are at high risk of developing chronic lung disease, which requires respiratory support and might have long-term sequelae. As lung inflammation plays an important role in pathogenesis, antileukotrienes have been explored in both clinical and animal studies. We aimed to assess the benefits and harms of antileukotrienes for the prevention and treatment of respiratory
