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BACKGROUND: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensi
Metachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the
This paper highlights the lives of Japanese and Korean subjects of Imperial Japan who were involved in opium production and circulation in Manchukuo. It discusses the dynamics, practices, and experiences of opium production and circulation. This paper provides a new reading of the diverse beneficiaries on the ground and of the opium industry in Manchukuo from the angles of production and circulati
Background: While shared decision making is a cornerstone of orthopedic care, orthopedic surgeons face challenges in tailoring their advice and expectation management to individual shoulder arthroplasty patients due to the lack of systematically summarized evidence-based knowledge. This systematic review aims to provide an overview of current knowledge on independent predictive effects of patient-
Fast-moving consumer goods (FMCGs) are products that have a short useful lifetime and are typically designed for single or limited uses followed by disposal. The disposable nature of FMCGs combined with ineffective waste recovery systems is causing global environmental problems. Various reusable packaging business models have emerged to tackle these problems; however, their influence is still low
Sixteen landcover classes in a representative Swedish environment were analyzed and classified using one Landsat TM scene and seven ERS-1 SAR.PRI images acquired during 1993. Spectral and backscattering signature separabilities are analyzed using the Jeffries-Matusita distance measure to determine which combinations of channels/images contained the most information. Maximum likelihood, sequential
We introduce the combination of digital holographic microscopy (DHM) and antibody microarrays as a powerful tool to measure morphological changes in specifically antibody-captured cells. The aim of the study was to develop DHM for analysis of cell death of etoposide-treated suspension cells. Results/methodology: We demonstrate that the cell number, mean area, thickness and volume were noninvasivel
BACKGROUND: Lung cancer remains one of the most challenging diseases to treat due to its heterogeneity. Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) mutations are genetic drivers in numerous cancer types including lung adenocarcinoma (LUAD). Despite recent advances in KRAS-targeted therapies, treatment resistance and limited therapeutic options necessitate advanced preclinical models, such as
We present the building blocks of an energy-efficient on-chip platform for neural network applications based on III-V semiconductor nanowires and nanopillar arrays. These will work as emitting and detecting neurosynaptic nodes for spiking nanocircuits, as light sensors that emulate navigational properties of insect vision systems.
Dust burden during the dust storms events imparts an adverse effect on human health and environment. The aim of this research is to provide a deeper understanding about the atmospheric dynamics of long-range transport of mineral dust for 8 severe dust storm events over the Indian region during the period 2008–2022. Transport of mineral dust analyzed based on MERRA-2 Dust column mass density, follo
In this study, a coupled transient thermomechanical finite element model is developed to examine the laser powder bed fusion (L-PBF) process of the Inconel 718 (IN718) and Oxide Dispersion Strengthened (ODS) superalloys (ODS-IN718). The linear isotropic elastic perfectly plastic constitutive model is implemented for the mechanical part whereas all the thermophysical properties are defined as fully
This paper looks at the role of gender in the shaping and exercise of political authority. Its empirical focus is a slum in central Trivandrum, Kerala's capital city, which is undergoing a phased process of formalisation and rebuilding funded through a flagship Indian national programme, the JNNURM. The upgrade project should offer a dense network of ‘invited’ spaces for female participation withi
The transcriptional mechanisms underlying tooth development are only beginning to be understood. Pitx2, a bicoid-like homeodomain transcription factor, is the first transcriptional marker observed during tooth development. Because Pitx2, Msx2, and Dlx2 are expressed in the dental epithelium, we examined the transcriptional activity of PITX2 in concert with Msx2 and the Dlx2 promoter. PITX2 activat
Context The context of this research is software process improvement (SPI) success factors for small and medium Web companies. Objective The primary objective of this paper is to propose a theoretical framework of SPI success factors for small and medium Web companies. Method The theoretical framework presented in this study aggregated the results of three previous research phases by applying prin
In order to provide clinical utility for research of how art therapists perceive clients’ inner change, the authors created a structured observational framework. This note-taking and assessment consist of five themes and sub-themes: Therapeutic Alliance, Creating, Affect-Awareness, Self-Awareness, and Ego-Strength. The framework was designed to be clinically-friendly, adaptable to various settings
Introduction: People living with acromegaly and neuroendocrine tumours (NETs) may be treated with injectable somatostatin receptor ligands (SRLs), administered by either a caregiver or as self-injection via a proprietary or generic device. Injection device attributes that contribute to ease of use and storage, minimise preparation requirements, and reduce injection pain are associated with improve
Title: From Board Games to Unicorns: Gamification and Its Impact on Ideation for Nascent Entrepreneurs Seminar date: January 11th, 2023 Course: FEKH99, Bachelor Degree Project in Entrepreneurship and Innovation Management, Business administration, Undergraduate level, 15 University Credit Points Authors: Jonathan Andersson, Måns Heurlin, Jonathan Rooth Supervisor: Joakim Winborg Keywords: Ga
The primary settling tank (PST) is often one of the first treatment steps at a wastewater treatment plant (WWTP) and is the first process in the plant to remove significant amounts of suspended solids. Its role in wastewater treatment however, has oftentimes been neglected and little effort has been made to optimize and model the process. The PSTs have historically been designed based on hydraulic
Applying contemporary ideas regarding the role literature may have had in human evolutionary history to literary analysis, using Herman Melville's Moby Dick as a case study. The paper focuses on the function of male bonding in the text, the ways in which the setting is defined by humanity's evolutionary past, and the artistic function of the hunt, as it is described in the text.
