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Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices

We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solv

Documenting Determinants of the Divorce Transition. Micro-Level Evidence from Sweden 1905–1967

Divorce increased dramatically during the twentieth century across the western world. There is surprisingly little research on the determinants of divorce during this transition. We investigate micro-level sociodemographic determinants of divorce in Sweden 1922–1967 using longitudinal data at individual and household level from southern Sweden, focusing on the associations between divorce and wome

A fast approximate method for simulating thermal pile heat exchangers

Ground source heat pump systems, operating in conjunction with vertical ground heat exchangers, will play a key role in decarbonising heating and cooling of buildings. Design of traditional borehole heat exchangers relies on tools which implement routine analytical relationships between heat transferred and the temperature change in the ground and circulating thermal fluid. However, for novel pile

KÁRMÁN VORTEX CITY OF DNA STRANDS

Kármán vortex streets are repeating patterns of swirling vortices, appearing when a fluid passes an obstacle at Re>50. We present an array of interacting vortices, a Kármán vortex city, that arises when a DNA solution flows through an array of micro posts at Re <0.5. Above thresholds in concentration and flow rate, the vortices formed behind posts interact, leading to concentration fluctuation wav

Finite-size scaling analysis of protein droplet formation

The formation of biomolecular condensates inside cells often involve intrinsically disordered proteins (IDPs), and several of these IDPs are also capable of forming dropletlike dense assemblies on their own, through liquid-liquid phase separation. When modeling thermodynamic phase changes, it is well known that finite-size scaling analysis can be a valuable tool. However, to our knowledge, this ap

Future physics opportunities for high-density QCD at the LHC with heavy-ion and proton beams

The future opportunities for high-density QCD studies with ion and proton beams at the LHC are presented. Four major scientific goals are identified: the characterisation of the macroscopic long wavelength Quark-Gluon Plasma (QGP) properties with unprecedented precision, the investigation of the microscopic parton dynamics underlying QGP properties, the development of a unified picture of particle

Regulation of eukaryotic aquaporins

Membrane-bound water channels known as aquaporins (AQPs) facilitate water transport across biological membranes along osmotic gradients. Since all living cells depend on their ability to maintain water homeostasis, this must be tightly regulated. In eukaryotes, this is achieved by gating, which involves a conformational change of the protein, thereby physically blocking water transport, or by traf

The Governance of Global Innovation Systems : Putting Knowledge in Context

Technological innovation increasingly depends on multiscalar actor networks and institutions. However, the developers of many conceptual frameworks explaining innovation success have paid only limited attention to this new reality, due to their focus on regions and countries as agents that shape innovation governance and as containers that provide institutional conditions for innovation success. I

Automated extraction of scenario sequences from disciplined dataflow networks

Analysing deadlock-freedom, boundedness and realtime constraints are crucial steps in the design of embedded streaming applications. Dataflow models of computation are often used to analyse such properties at design-time. To that end, scenario-based dataflow techniques isolate the individual operating scenarios of a dynamic application and analyse the executions of the possible scenario sequences.

Phase-field modelling of stress corrosion

The evolution of surfaces exposed to an aggressive environment and mechanical load is studied. The evolution is the initial part of a stress corrosion process that leads to pitting, crack initiation and growing cracks. In conventional fracture analyses the growth rate of the crack may be computed using a modified Paris' law. However, a known or a postulated crack is required. A serious drawback is

In situ and laboratory measurement of service equipment decoupling in lightweight constructions

The latest version of the Swiss standard for building acoustics (SIA181) introduced a new measurement method, based on a balanced- Arm hammer, for evaluating the decoupling performance of service equipment. This method was developed for reproducing in a standard manner the manipulation of service equipment in bathrooms and kitchens. In this study, we are investigating the relevance of such method