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During the past few years the focus on bioprocess monitoring and control has increased. An area still under intensive development is the sampling methods for efficient and rapid analysis during fermentations. In this thesis, an online-sampling and monitoring scheme was developed using the versatile automated continuous flow system (VersAFlo) for recombinant protein production. From the implementat
With modern day interest to continue the reduction of harmful emissions and improve the efficiency of combustion devices, the need to further improve upon accuracy and ability to describe combustive processes is of high value. Nowadays, multiple capable point (0D) and two-dimensional measurement (2D) techniques exist for flame investigation, however as combustion nearly always is a three-dimension
The accuracy and portability of depth cameras have increased by a lot in recent years, which allows for advanced 3D scanning of the environment for robotic applications. In this thesis we have developed a system that uses a depth camera mounted on a robot arm to identify and localize arbitrary objects, and give hints on how to move the camera to get better localization results. The system works by
CellaVision develops automated microscopy for blood analysis. Their products can pre-classify 19 different types of white blood cells and support the medical technologist performing the final classification. CellaVision provides reference cells. The reference cells are a fixed set of cells handpicked by a technologist, chosen to be typical for that specific class. The reference cells are static, i
Antalet personer som lever med en kronisk sjukdom ökar, detta som en konsekvens av bland annat en snabbt ökande äldre befolkning. Kroniska sjukdomar orsakar inte bara mänskligt lidande, utan är också en ekonomisk börda för samhället. För att lindra lidandet och minska kostnaderna kopplade till kroniska sjukdomar kan användandet av digitala hälsotjänster vara en möjlighet. För närvarande är förväntThe amount of people living with chronic diseases is increasing. Chronic diseases do not only induce human suffering, it is also an economic burden on society. To ease the suffering and reduce the costs connected to chronic diseases, the usage of digital health services might be a possibility. Currently, the expectations on such services are high, but not met. To better meet the expectations, this
This degree project aims to develop standard methods for determination of the size distribution in different samples using laser diffraction, as well as to create methodologies for development of new methods for unknown samples. The size distribution is crucial to understand for pharmaceutical products since it affects properties such as the stability and bioavailability of the product. A way to
The beverage packaging industry is growing rapidly, driven by urbanization and changing lifestyles. Demand for packaged beverages with extended shelf life is driving sales of products with superior barrier properties, due to the high environmental impact of food waste compared to packaging waste. Despite progress, packaging waste represents more than a third of total waste. Thus, milk and plant-ba
The thesis explores the decision-making process of sustainable entrepreneurs for securing external funds by adopting the “triple bottom line” research perspective (Hall et al., 2010; Sarango-Lalangui, 2018). It delves into how sustainable entrepreneurs assess and exploit funding opportunities while balancing their economic and non-economic goals. The research addresses two primary questions: what
Internal erosion is one of the major reasons for embankment dam failures. Despite this, the knowledge of the temporal development of internal erosion in full scale structures is limited. Detection of internal erosion is complicated using conventional methods, and new or improved methods are appreciated. Hallby was the first Swedish embankment to get a permanently installed monitoring system intend
In this thesis some research questions regarding durability and quality of roads has been investigated. The questions are analyzed from an image analysis point of view and aims to be a complement to existing methods for analyzing asphalt. One important factor for the durability of the asphalt layer on roads is the affinity between the stones in the asphalt and the binder that holds the stones tog
Security of supply is widely addressed in the academia. In this paper we conduct a review of methodologies, discuss strengths and weaknesses and identify areas that would benefit from further research and methodology development. A distinction is made between methodologies used to assess general vulnerability and those that value the outcome of insecurity by testing how energy systems respond to d
Purpose Timely knowledge of the bacterial etiology and localization of infection are important for empirical antibiotic therapy. Thus, the goal of this study was to evaluate routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. Methods In this prospective study, 54 adult patients with bacterial infections admitted to the Department of Infectious Disease
The objective was to develop evidence -based recommendations and a research and educational agenda for the non-pharmacological management of hip and knee osteoarthritis (OA). The multidisciplinary task force comprised 21 experts: nurses, occupational therapists, physiotherapists, rheumatologists, orthopaedic surgeons, general practitioner, psychologist, dietician, clinical epidemiologist and patie
This contribution concerns the development of generic methods and tools for robust optimal control of high-pressure liquid chromatographic separation processes. The proposed methodology exploits a deterministic robust formulation, that employs a linearization of the uncertainty set, based on Lyapunov differential equations to generate optimal elution trajectories in the presence of uncertainty. Co
A method for simultaneous determination of the diffusion and sorption properties of cement-based materials is presented. It is a gravimetric method where one small specimen is exposed to stepwise changes in relative humidity while its mass is being measured. As sorption in cement-based materials is slow, the change in relative humidity to the next level is made before final equilibrium has been re
We present an overview of recent work on the spectroscopy of tungsten ions, related to tokamak edge plasma. The spectra were recorded from the newly-built low energy electron beam ion traps (EBITs) in the Shanghai EBIT laboratory. By analyzing the spectra with the help of accurate theoretical calculations, using state-of-the-art techniques, we were able to identify term and fine structure splittin
Background: Standardized techniques to detect HIV-neutralizing antibody responses are of great importance in the search for an HIV vaccine. Methods: Here, we present a high-throughput, high-content automated plaque reduction (APR) assay based on automated microscopy and image analysis that allows evaluation of neutralization and inhibition of cell-cell fusion within the same assay. Neutralization
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglyceri
