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Deep proteomic analysis on biobanked paraffine-archived melanoma with prognostic/predictive biomarker read-out

The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in tumor biobanks and available at hospital pathology departments. In our retrospective biobank pilot study, 90 FFPE sa

Proteomic analysis enables distinction of early- versus advanced-stage lung adenocarcinomas

BACKGROUND: A gel-free proteomic approach was utilized to perform in-depth tissue protein profiling of lung adenocarcinoma (ADC) and normal lung tissues from early and advanced stages of the disease. The long-term goal of this study is to generate a large-scale, label-free proteomics dataset from histologically well-classified lung ADC that can be used to increase further our understanding of dise

Low physical activity is related to clustering of risk factors for fracture—a 2-year prospective study in children

Summary: The study investigates the effect of physical activity (PA) on a composite score for fracture risk in pre-pubertal children. Low PA in children is related to the composite score for fracture risk and the pre-pubertal years seem to be a period when PA positively affects the score. Introduction: This study evaluates if PA in children is related to clustering of risk factors for fracture. Re

Involvement of chromatin remodeling genes and the Rho GTPases RhoB and CDC42 in ovarian clear cell carcinoma

Objective: Ovarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype with distinct clinical features, but may nonetheless be difficult to distinguish morphologically from other subtypes. There is limited knowledge of genetic events driving OCCC tumorigenesis beyond ARID1A, which is reportedly mutated in 30-50% of OCCCs. We aimed to further characterize OCCCs by combined global

Cancer among patients with diabetes, obesity and abnormal blood lipids: a population-based register study in Sweden.

OBJECTIVE: To study how the incidence of cancer is related to diabetes, obesity or abnormal blood lipids. METHODS: Diagnosis of diabetes, obesity or abnormal blood lipids was studied 0-10 years prior to the diagnosis of cancer in 19,756 cases of cancer and in 147,324 controls matched regarding age, sex and domicile. RESULTS: Diabetes was significantly more common prior to diagnosis in patients w

Prevalence of germline TP53 mutations and history of Li-Fraumeni syndrome in families with childhood adrenocortical tumors, choroid plexus tumors, and rhabdomyosarcoma: A population-based survey.

PURPOSE: Whether childhood adrenocortical tumors (ACTs), choroid plexus tumors (CPTs), and rhabdomyosarcoma (RMS) are early manifestation of Li-Fraumeni syndrome (LFS) is uncertain. In this study, we evaluated the frequency of germline TP53 mutations and family history in a population-based series of patients. PATIENTS AND METHODS: We identified children (≤18 years) diagnosed between 1958 and

Molecular profiling reveals low- and high-grade forms of primary melanoma

PURPOSE: For primary melanomas, tumor thickness, mitotic rate and ulceration are well-laid cornerstones of prognostication. However, a molecular exposition of melanoma aggressiveness is critically missing. We recently uncovered a four-class structure in metastatic melanoma that predicts outcome and informs biology. This raises the possibility that a molecular structure exists even in the early st

Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype.

Phenotypic characteristics were examined in melanoma-prone southern Swedish CDKN2A (p16-113insArg/p14ARF-128insSer) mutation families, in relation to the CDKN2A genotype, nevi, clinically atypical nevi (CAN) and melanoma. Individuals from eight melanoma-prone families, with index patients carrying the CDKN2A mutation, were offered skin examinations and genotyping (CDKN2A and MC1R). Ninety-three in

Självkörande bilar i urbana miljöer - En studie med avseende på trafiksäkerhet

Until today, the performance of a motor vehicle has required the present of a human driver. With a human driver follow human factors. In recent years, more automatic functions have been implemented in new cars and self-driving cars at higher levels have begun to develop. This development limits the influence of the human factors. The purpose is with the thesis project, to investigate which problem

Kan akademin hjälpa industrin utveckla mer robusta grundvattenmodeller? En studie av moderna svenska industriframtagna grundvattenmodeller

Grundvattenmodellering används ofta av yrkesverksamma hydrogeologer för att ta fram predikt- ioner som ska fungera som underlag i beslutsfattandeprocesser. I Sverige finns det inga lagar som reglerar hur en grundvattenmodell ska utformas, och de kan se väldigt olika ut. Därför har syftet med detta arbete varit att under- söka svenska grundvattenmodeller skapade av industrin i beslutsändamål under Groundwater modeling is often employed by professional hydrogeologists to make predictions to be used by regulators in decision-making. In Sweden, there are no laws governing the way in which a groundwater model may be created or shaped, and therefore they may differ wildly from one another. Thus, the goal of this study has been to research Swedish groundwater models created by the industry during

Cumulative Wisdom or Compounding Complexity: The learning curve among serial acquirers. (Sweden)

This thesis investigates the performance dynamics of serial acquirers in the Swedish market, specifically focusing on their ability to realize cost synergies over time. Through an empirical analysis of Swedish firms engaging in mergers and acquisitions (M&A) between 2010 and 2019, we aimed to determine whether serial acquirers exhibit improved synergy realization in subsequent acquisitions com

Contribution of indoor-generated particles to residential exposure

Abstract The majority of airborne particles in residences, when expressed as number concentrations, are generated by the residents themselves, through combustion/thermal related activities. These particles have a considerably smaller diameter than 2.5 μm and, due to the combination of their small size, chemical composition (e.g. soot) and intermittently very high concentrations, should be regard

Högfrekventa tryckvariationer under de senaste århundradena

Populärvetenskaplig sammanfattning: Solen värmer jordytan olika mycket på olika platser dels beroende på om ytan är land, hav eller is och dels beroende på den breddgrad ytan är belägen på. Denna ojämna uppvärmning ger upphov till regionala ojämnheter i lufttrycket. Det är dessa tryckojämnheter som styr vindriktningarna i atmosfären och därmed vart alla vädersystemen rör sig. Det är alltså den ojäLong time-series of pressure measurements often have high quality because the early instruments are more or less the same as the modern ones. A time-series from Lund consisting of three daily measurements from 1780-1997 has been homogenised and is therefore suitable for analysing possible influences of the enhanced greenhouse effect. According to a two-layer model of the atmosphere one finds a shi

An updated kinetic mechanism for aluminum gas-phase combustion in oxygen and steam environments

Aluminum (Al), as a carbon-free energy source, features favorable characteristics regarding its production, transportation, utilization, and recyclability. The combustion of single Al particles mainly occurs as a vapor-phase diffusion flame, wherein the gas-phase combustion kinetics plays an important role. However, the understanding of the kinetics is still limited and rate constants for the same

Molnens påverkan på jordens strålningsbalans och klimatsystem

Molnens roll i klimatsystemet har studerats och deras påverkan på solens inverkan på jordens energibalans. Jordens albedo påverkar energibalansen genom att den påverkar hur mycket av solens instrålning som reflekteras eller absorberas. Moln påverkar jordens albedo och spelar därför en viktig roll i denna balans. Molnbildning sker till nära 100% i troposfären och där finns allt det vi kallar väder.The role of clouds in the climate system has been studied and their impact on the Sun's impact on the Earth's energy balance. The Earth's albedo affects the energy balance by influencing how much of the Sun’s radiation is reflected or absorbed. Clouds affect the Earth's albedo and therefore play an important role in this balance. Cloud formation occurs almost 100% in the tropospher

The role of public relations practitioners in the reputation management of CEOs - Results of a shadowing study

This paper combines theory and data collected from a shadowing study to explore the role of communication and public relations practitioners in reputation management. In seeking to explore the role communication managers have on the reputation of a CEO and the corporate reputation, this study builds on the existing research on roles research and corporate reputation. The theoretical framework conn

Asp kulturgeografi ekonomisk geografi 20201126

Allmän studieplan för utbildning på forskarnivå i kulturgeografi/ekonomisk geografi och geografi med kulturgeografisk inriktning Sida 1 av 11 Fakultetsstyrelsen ALLMÄN STUDIEPLAN KULTURGEOGRAFI/EKONOMISK GEOGRAFI Diarienummer U 2020/899 Datum 2020-11-26 Allmän studieplan för utbildning på forskarnivå i kulturgeografi/ekonomisk geografi och geografi med kulturgeografisk inriktning Allmän studieplan

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2020-12/asp_kulturgeografi_ekonomisk_geografi_20201126.pdf - 2026-05-30

LPED 2019 5

Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ Educational Assortative Mating, Gender Equality, and Income Differentiation across Europe: A Simulation Study MIEKE C.W. EECKHAUT, MARIA STANFORS LUND PAPERS IN ECONOMIC DEMOGRAPHY 2019:5 Copyright is held by the author(s)

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2019_5.pdf - 2026-05-30

Ny i samverkan, 22:e april 2026

Ny i samverkan, 22:e april 2026 | Sacoråd Göteborgs Stad Hoppa till huvudinnehåll Öppna sökruta Öppna Huvudmeny Sök på saco.se Om oss In English Kalendarium Våra förbund Akavia DIK Naturvetarna SRAT Sveriges Ingenjörer Sveriges Arbetsterapeuter Sveriges Psykologförbund Sveriges Skolledare Presentation av lokalföreningen ' Skolledningsnytt ' Arbetsmiljö och skyddsorganisation Arbetstid och återhämt

https://www.saco.se/fortroendevald/lokalt-fackligt-arbete/lokala-akademikerforeningar/kommun-region/centrala-sacoradet-i-goteborgs-stad/Om-oss/Kalendarium/2026/instegsutbildning-samverkan-22e-april-2026/ - 2026-04-21

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Upptecknaren 2019 FOLKLIVSARKIVET | LUNDS UNIVERSITET 2 UPPTECKNAREN 2019 Upptecknaren 2019 FÖRORD UPPTECKNARNA OCH UPPTECKNINGARNA Karin Gustavsson (sid. 5) NILS MÅNSSON MANDELGREN OCH DET INTERNATIONELLA NÄTVERKETS BETYDELSE FÖR UTGIVNINGEN AV MONUMENTS SCANDINAVES DU MOYEN AGE Andreas Alm (sid. 12) MUSIKANVÄNDNING OCH MUSIKLYSSNANDE – FÖRÄNDRINGAR I BRUKET AV CD- OCH VINYLSKIVAN UNDER 20 ÅRS TI

https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/Upptecknaren/Upptecknaren_2019.pdf - 2026-05-28