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Function, information, and contributions : An evaluation of national multidisciplinary team meetings for rare cancers

National virtual multidisciplinary team meetings have been established in Swedish cancer care in response to centralized treatment of rare cancers. Though national meetings grant access to a large multidisciplinary network, we hypothesized that video-based meetings may challenge participants’ contributions to the case discussions. We investigated participants’ views and used observational tools to

Autoimmune diseases and hematological malignancies : exploring the underlying mechanisms from epidemiological evidence

Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune diseases has led to speculation that the risk of malignancy might be higher or lower in patients with such diseases. However, the rarity and heterogeneity of both autoimmune diseases and malignancies is the main challenge

Styrelseprotokoll20190410

Styrelseprotokoll 2020-04-10 Sida 1 av 4 STYRELSEPROTOKOLL Diarienummer Biologiska institutionen Datum 2019-04-10 Protokoll institutionsstyrelsen Närvaro Närvarande ledamöter Carin Jarl Sunesson, prefekt, ordförande, Marita Cohn, Nils Cronberg, Violeta Kaleskovska, Alice Mellring, Carina Rasmussen, Karin Rengefors, Tobias Uller, Niklas Wahlberg, Helena Westerdahl Frånvarande ledamöter Johannes Rou

https://www.biologi.lu.se/internt/sites/biologi.lu.se.internt/files/2020-12/styrelseprotokoll20190410.pdf - 2026-05-28

Societal consequences of critical infrastructure vulnerabilities: integrating power system and regional inoperability input-output models

Critical infrastructures provide indispensable services to society and extensive disruption of these give rise to large societal consequences. Most risk-related studies of critical infrastructures, however, focus rather narrowly on the direct consequences, e.g. expressed by services not supplied or cost of nonsupplied services. Although these measures might serve as a proxy for the direct societal

Comparison of vulnerability and reliability analysis of technical infrastructures

The society depends on reliable and robust services provided by technical infrastructures for its function. The impact of large-scale outages due to the inherent vulnerabilities of technical infrastructures has been demonstrated, for example, by the power outage in the U.S. in 2003 and the power outages in Sweden due to the storms Gudrun in January 2005 and Per in January 2007. Two of the main app

Guldet blev till papper: 1930-talets pressdebatt om svensk penning- och valutapolitik

I september 1931 tvingades Sverige överge guldmyntfoten. Landet bytte myntfot – från guld till papper – med stabilisering av prisnivån som officiellt mål. Det var första och enda gången ett land försökt sig på något sådant. Sverige anses därigenom ha föregripit den inflationsmålspolitik som sedan 1990-talet bedrivs i ett antal länder, däribland Sverige. I denna bok undersöks hur den nya penning-

Genetic profiles distinguish different types of hereditary ovarian cancer.

Heredity represents the strongest risk factor for ovarian cancer with disease predisposing mutations identified in 15% of the tumors. With the aim to identify genetic classifiers for hereditary ovarian cancer, we profiled hereditary ovarian cancers linked to the hereditary breast and ovarian cancer (HBOC) syndrome and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Genome-wide arr

Interactions between oral contraceptive status and GSTM1 and GSTT1 deletions on insulin-like growth factor-1 (IGF-1) plasma levels in young healthy women.

OBJECTIVE: Insulin-like growth factor-1 (IGF-1) is essential for the pubertal growth spurt and for normal mammary gland development. IGF-1 increases premenopausal breast cancer risk. Oral contraceptives (OCs) decrease IGF-1 in most women. The endogenous estrogens and their metabolites also influence IGF-1 levels. Glutathione S-transferases (GSTs) are involved in estrogen metabolism. We aimed to st

Towards optimised information about clinical trials; identification and validation of key issues in collaboration with cancer patient advocates.

DELLSON P., NILBERT M., BENDAHL P-O., MALMSTROM P. & CARLSSON C. (2010) European Journal of Cancer Care Towards optimised information about clinical trials; identification and validation of key issues in collaboration with cancer patient advocates Clinical trials are crucial to improve cancer treatment but recruitment is difficult. Optimised patient information has been recognised as a key iss

12-14 week scan with emphasis on risk assessment for fetal structural malformations and fetal loss

Popular Abstract in Swedish Bakgrund I Sverige erbjuds samtliga gravida kvinnor ett rutinultraljud vid 18-20 graviditetsveckor. Syftet med undersökningen är att fastställa antalet foster, uppskatta graviditetslängd samt granska fosteranatomin för att upptäcka eventuella missbildningar. En del missbildningar kan man se med ultraljud, men långtifrån alla. Att redan under graviditeten känna till om The aim was to evaluate first trimester nuchal translucency (NT) measurement for detection and risk assessment of fetal malformations and fetal loss. 39 572 pregnant women were randomised to either a routine ultrasound scan at 12-14 weeks including NT measurement or to a routine scan at 18-20 weeks. Prenatal diagnosis of major congenital heart malformations was compared between the two groups. In

Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investig

Validation of a Self-Concept Scale for Lynch Syndrome in Different Nationalities

Learning about hereditary cancer may influence an individual's self-concept, which otherwise represents a complex but stable cognitive structure. Recently, a 20-statement self-concept scale, with subscales related to stigma-vulnerability and bowel symptom-related anxiety, was developed for Lynch syndrome. We compared the performance of this scale in 591 mutation carriers from Denmark, Sweden and C

Discovery-based Protein Expression Profiling Identifies Distinct Subgroups and Pathways in Leiomyosarcomas.

Soft tissue sarcomas (STS) are malignant tumors of mesenchymal origin. A substantial portion of these tumors exhibits complex karyotypes and lack characterized chromosomal aberrations. Owing to such properties, both histopathological and molecular classification of these tumors has been a significant challenge. This study examines the protein expression of a large number of human softtissue sarcom