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Objective: Adverse event (AE) monitoring is central to assessing therapeutic safety. The lack of a comprehensive framework to define and grade maternal and fetal AEs in pregnancy trials severely limits understanding risks in pregnant women. We created AE terminology to improve safety monitoring for developing pregnancy drugs, devices and interventions. Method: Existing severity grading for pregnan
Background Lifestyle exposures play a major role in the development of disease, yet people vary in their susceptibility. A critical step towards precision medicine is identifying individuals who are resilient or sensitive to the environment, and, assess whether the allocation to these predicted groups are more or less likely to develop cardiometabolic disease.Methods We have used repeated data fro
This Master Thesis has been written at EADS (European Aeronautic Defence and Space Company) Airbus in Bremen.The work contains a description of a few methods when linearising SystemBuild models in MATRIXx. MATRIXx is a tool for matrix manipulations (similar to Matlab) and SystemBuild is a graphical modeling environment (similar to SimuLink). The methods examined are the linearization command “lin”
Mexico, the second largest economy in Latin America, has almost eradicated extreme poverty according to the Millennium Development Goals; however, official statistics show that by national standards poverty levels are still quite high, reaching up to half its population. This paper looks into how the determinants of poverty in Mexico have evolved after the last major economic crisis the country ex
Considering the current resources scarcity, Wastewater Treatment Plants (WWTP) should be adapted to become more sustainable. For example, it is possible to recover resources present in municipal wastewater. However, regional studies about integration of resource recovery processes at different scales or about the main barriers to implementation in developing countries are missing in the literature
Spectral analysis encompasses several powerful signal processing methods. The papers in this thesis present methods for finding good spectral representations, and methods both for stationary and non-stationary signals are considered. Stationary methods can be used for real-time evaluation, analysing shorter segments of an incoming signal, while non-stationary methods can be used to analyse the ins
Sweden has set a goal to produce 100% renewable electricity in 2040. In order to accomplish this, a transition towards renewable energy (RE) is necessary. However, the development of RE needs to coexist with other interests of the nation, as RE typically occupies large areas of land or off shore water. This has resulted in conflicts, for instance, between offshore wind power development and nation
Interpreting EEG measurements is of great relevance, both for developing underlying neuroscientific theory and improving existing applications. In this study, two networks with different approaches to time-frequency analysis and feature selection are compared on simulated and real data for semantic and emotional perception. The first network uses the Morlet wavelet transform to achieve adaptable f
Interpreting EEG measurements is of great relevance, both for developing underlying neuroscientific theory and improving existing applications. In this study, two networks with different approaches to time-frequency analysis and feature selection are compared on simulated and real data for semantic and emotional perception. The first network uses the Morlet wavelet transform to achieve adaptable f
As commodities are becoming more popular and accessible assets for speculative and hedging purposes, the limited research regarding risk management for said asset-class justifies further contribution to the deficient output. Many previous studies have highlighted the extraordinary high volatility, with non-linear and clustering characteristics associated with commodities. Hence, incorporating vola
Power production represents one fourth to one third of all CO2 emissions. Carbon Capture and Storage (CCS) in one way to approach the increasing problem with CO2 emissions from fossil fuelled power plants. The CO2 is separated, compressed and transported to a final storing site. To allow more efficient transport and to match the pressure of the final storing site, the CO2 is compressed to a superc
The extent of remediation of contaminated industrial sites depends on spatial heterogeneity of contaminant concentration and spatially explicit risk characterization. We used sequential Gaussian simulation (SGS) and indicator kriging (IK) to describe the spatial distribution of polycyclic aromatic hydrocarbons (PAHs), pH, electric conductivity, particle aggregate distribution, water holding capaci
Gaucher disease type 1 (GD type 1) and Diamond-Blackfan anemia (DBA) are rare genetic disorders affecting the hematopoietic system and routinely treated by administration of drugs with variable clinical efficacy. Though effective in alleviating disease symptoms in large cohorts of patients, these treatment options have the major drawback of being non-curative. Currently, bone marrow transplantatio
The aim of this study was to evaluate how the fixed furniture dimensions match with students' anthropometry and to describe head, upper back and upper limbs postures and movements. Evaluation was performed in 48 students from a Brazilian state school. Furniture dimensions were measured with metric tape, movements and postures by inclinometers (Logger Tecknologi, Akarp, Sweden). Seat height was hig
1. Thousands of lakes in the Northern Hemisphere are experiencing a continuous increase in water temperature and colour. While increasing temperature is an effect of climate change, several factors are suggested to drive the increasing water colour, including climate change, altered land use and reversed acidification. 2. In this mesocosm study, we study the effects on pelagic production and sedim
Ideally, neuronal functions would be studied by performing experiments with unconstrained animals whilst they behave in their natural environment. Although this is not feasible currently for most animal models, one can mimic the natural environment in the laboratory by using a virtual reality (VR) environment. Here we present a novel VR system based upon a spherical projection of computer generate
Chronic neural interfaces that are both structurally and functionally stable inside the brain over long time periods and that have minimal effects on the physiological conditions of the neural tissue to be studied hold great promise to become invaluable research and clinical tool in the near future. In this chapter, I will briefly review the state of the art of neural interfaces and the concepts b
Popular Abstract in Swedish Belysning står för en femtedel av den globala elanvändningen. I Sverige motsvarar efterfrågan på energi för belysning i kontorsbyggnader 20% av den totala elanvändningen. Utbyte av gamla belysningsanläggningar anses vara bland de mest kostnadseffektiva sätten att minska energianvändningen i byggnader. I synnerhet utlovar användningen av avancerade ljusstyrningssystem enLighting accounts for one-fifth of global electricity use. In Sweden, energy demand for lighting corresponds to 20% of the total electricity use in office buildings. Lighting retrofit measures are considered to be among the most cost-efficient way to reduce energy use in buildings. In particular, the use of advanced lighting control systems promises energy savings of between 2 and 60%, but system
In the face of climate change wind energy plays an increasing role in Norway. The construction of new wind farms causes opposition and conflicts with, among others, Sámi reindeer herders who are concerned about losing their pastures. By using Schlosberg’s (2004) environmental justice framework, I explore the justice implications of wind energy with regard to Sámi reindeer husbandry in the case of
