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BackgroundThe purpose was to evaluate the prognostic impact of aryl hydrocarbon receptor (AHR) genotypes in relation to lifestyle and adjuvant treatments in breast cancer.MethodsAHR genotyping was performed on genomic DNA from 1701 patients included 2002–2016 in Lund, Sweden, and followed for up to 15 years. Eight AHR polymorphisms and eight haplotypes were analysed using survival and interaction
Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B (MTNR1B) is robustly associated with increased risk of T2D. This single-nucleotide polymorphism (SNP; rs10830963; G-allele) is an expression quantitative trait locus (eQTL) in human pancreatic islets, conferri
Background During the last decade, evidence has emerged on selective glomerular hypofiltration syndromes (SGHS), defined by selectively reduced filtration of middle-sized molecules irrespective of kidney function and resulting in a low ratio between cystatin C- and creatinine-based estimated glomerular filtration rates (eGFRcys/eGFRcr). We aimed to examine whether SGHS is a hallmark of premature k
Background: The global food system is a major contributor to climate change, accounting for about one-third of human-induced greenhouse gas emissions (GHGE). Shifting toward plant-based diets offers potential benefits for both planetary health and chronic disease prevention. However, epidemiological evidence linking dietary GHGE to health outcomes remains limited and inconsistent. Objective: To ex
In inflammatory bowel disease (IBD) the pathogenetic process is characterized by dysbiosis, increased permeability, translocation, and immune activation. The aim of the present study was to assess the presence of viable bacteria in the blood of patients with IBD and to correlate the findings with clinical characteristics. The study included 28 patients with Crohn’s disease (CD) (median age 38 year
Passivity refers to spontaneous formation of a passive film on the surface of metals. High stability of the passive film on advanced alloys relies on the repassivation ability of the alloys in corrosive environments. Two Ni-base superalloys (Ni-22Cr-9Mo-5Fe-2Nb and Ni-18Cr-3Mo-20Fe-5Nb) are studied to elucidate the mechanism of repassivation through a combination of multimodal in-situ synchrotron
High-order harmonic generation (HHG) in gases has been studied for almost 40 years under many different conditions, varying the laser wavelength, intensity, focusing geometry, target design, gas species, etc. However, no systematic investigation of the effect of the pulse duration has been performed despite its expected impact on phase-matching of the high-order harmonics. Here, we develop a compa
Fluoride toxicity has become a significant global public health concern, with drinking water being a major source of exposure. This study aimed to determine groundwater fluoride concentration and assess its non-carcinogenic health effects on human health. A longitudinal study design was applied to select water samples in dry and wet seasons from Adama City and Wenji Gefersa town of Ethiopia. Groun
SummaryElevated HDL-C levels are generally regarded as prognostically favorable in cardiovascular disease. Our study shows that higher HDL cholesterol levels are prospectively associated with 18% increased risk of new-onset fractures in men but not in women. Higher HDL cholesterol may be a novel risk factor for developing fractures in men.PurposeIncreased high-density lipoprotein cholesterol (HDL-
Coherent extreme ultraviolet (XUV) radiation can be generated in a tabletop configuration via high-order harmonic generation (HHG) in gases. While HHG is inherently inefficient, increasing the conversion efficiency (CE) is crucial for many applications, such as coincidence spectroscopy [1] and coherent imaging [2], which require high XUV throughput. Previous calculations suggest that one way to im
Background and objective: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer. There is a need to harmonise existing guidelines and reporting recommendations for PSMA PET/CT. The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aims to consolidate classifications and recommen
The preparation of ultra-thin PtSn-alloyed layers by molecular beam epitaxy was studied using low-energy electron microscopy (LEEM) and micro-diffraction (μ-LEED). Deposition at a sample temperature of 435 °C initially results in the formation of a Pt3Sn/Pt(111) layer showing a (2 × 2) reconstruction. With continued Sn deposition, a Pt2Sn/Pt(111) layer develops, showing a (3×3)R30° reconstruction.
BACKGROUND AND AIM[|]The incidence of skin cancer has risen sharply over the past 30 years - coinciding with the rapidly increasing tattoo trend. In Sweden, 20% of the population is tattooed. The link between tattoos and skin cancer needs to be investigated, due to the presence of carcinogenic chemicals in tattoo ink, and the lack of epidemiological studies of the association. We aimed to investig
Background and objective: Although cardiovascular toxicity from modern systemic treatments in metastatic hormone-sensitive prostate cancer (mHSPC) remains a concern, real-world data are limited. We aimed to characterise patients treated for mHSPC across multiple large cohorts and estimate cardiovascular adverse event (AE) risks. Methods: Leveraging PIONEER's Big Data platform, with databases stand
Aberrant protein aggregation into amyloid fibrils is often catalyzed by interfaces. Therefore, it is important to characterize the surface activity of chaperone proteins having the ability to suppress amyloid formation. The air–water interface is of large practical significance in experimental setups used to study aggregation kinetics in vitro, but in addition, the binding of chaperones to hydroph
Layered transition metal dichalcogenides (TMDs) are model systems to investigate the interplay between superconductivity and the charge density wave (CDW) order. Here, we use muon spin rotation and relaxation (μ+SR) to probe the superconducting ground state of polycrystalline 2H-TaS2, which hosts a CDW transition at 76 K and superconductivity below 1 K. The μ+SR measurements, conducted down to 0.2
Aim Habitual physical activity (PA) affects metabolism and homeostasis in various tissues and organs. However, detailed knowledge of associations between PA and cardiovascular disease (CVD) risk markers is limited. We sought to identify associations between accelerometer-assessed PA classes and 183 proteomic and 154 metabolomic CVD-related biomarkers. Method We utilized cross-sectional data from t
Objective: To evaluate the effects of excluding fatty tissue in QSM of human knee cartilage. Materials and methods: Gradient echo images from 18 knee-healthy volunteers were acquired, from which chemical shift corrected field perturbation maps were calculated. Based on these, QSM maps were reconstructed using morphology enabled dipole inversion and one of three masking alternatives: (1) excluding
Background: Influenza ranges from a mild and self-limiting infection to a life-threatening disease with high mortality despite intensive care. Conclusive data on the association between influenza type/subtype and mortality among adults treated at intensive care units (ICU) is lacking. Objectives: To investigate the mortality in adults admitted to ICU with laboratory-confirmed influenza during thre
