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Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
The vast majority of patients with pancreatic cancer present with unresectable disease and precision medicine is lagging behind. Circulating tumor DNA (ctDNA) has emerged as a promising tool, both as a proxy for tumor burden and for capturing tumor heterogeneity, but optimal gene panels and prognostic cutoffs remain to be determined. Herein, we applied ultra-deep ctDNA sequencing using a customize
Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat
Background: For patients investigated with radiopharmaceuticals, it is important to be able to perform valid calculations of the absorbed dose in organs and tissues. An internal dosimetry computer program, IDAC-Dose2.1, has been updated to be based on the ICRP specific absorbed fractions and computational framework of internal dose assessment for 12 adult and paediatric reference individuals given
Firms require multi-stakeholder ecosystems to successfully create and implement circular business models for electric vehicle (EV) battery second life. However, there is a notable absence of guiding instruments to assist EV battery ecosystem actors in formulating and managing strategies for battery second-life operations. This study's aim is to analyze how circular ecosystems are formed and manage
Background: Expanding access to self-management via Digital Health Technologies may supplement traditional care, mitigating pressures on primary care through self-management. Primary Care Physicians (PCP) can play a critical role in the integration of digital health technologies into patient care, but it is unclear what factors influence PCPs’ recommendation of such technologies. Aims: To identify
Stable carbon isotope curves derived from Lower Triassic carbonate rocks from three Iranian sections are established to investigate changes in the carbon cycle during the Early Triassic in this area. The sections are located in the south-center (Abadeh), north (Amol), and northwest (Zal) of Iran. All three curves show a similar pattern starting out with high δ13C values in the uppermost Permian de
This Letter presents a search for highly ionizing magnetic monopoles in (Formula presented) of ultraperipheral (Formula presented) collision data at (Formula presented) collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion dat
A combination of searches for the single production of vectorlike top quarks ((Formula presented)) is presented. These analyses are based on proton-proton collisions at (Formula presented) recorded in 2015-2018 with the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of (Formula presented). The (Formula presented) decay modes considered in this combination ar
Introduction: Worldwide, exposure to sexual violence has widespread consequences for survivors’ health and for their communities. There is still insufficient understanding of how to design support and care services for survivors in a multiorganizational context. This study aims to map and explore support and care for survivors of sexual violence from a multiorganizational perspective in Sweden, to
Endovascular therapy (EVT) has proven benefit for patients with anterior circulation large vessel occlusion (LVO) strokes with moderate-to-severe deficits, but its value in patients presenting 6-24 hours after onset with mild symptoms (NIH Stroke Scale score ≤5) remains unclear. This journal club article examines a retrospective analysis of CLEAR registry data comparing EVT with medical management
Hyperfine structure measurements have been performed in some neutron-deficient gold isotopes, using on-line atomic-beam magnetic resonance (ABMR) techniques at the ISOLDE facility, CERN. The following results have been obtained: 185Au, I = 5/2; 187Au, Δv = 44.35(60) GHz, μ = 0.72(7) n.m. and 188Au, Δv = ± 2992(30) MHz. A discussion of the influence of the hyperfine anomaly is included. With due re
Numerical models of meteorite delivery from impacts on the Moon have demonstrated that the impact event forming the lunar crater Tycho (~85 km diameter; ca. 109 Ma age) would have delivered considerable amounts of ejected material to Earth. The ejecta, containing lunar Ti- and V-rich chrome spinels, would have been distributed globally and admixed with seafloor sediments over a few meters of a typ
The role of education for school-aged refugee children has evolved throughout history, influenced by time, geopolitical contexts, public perceptions, and ideas about the purposes of education. This article examines refugee education in Finland and Sweden over the past century, focusing on three periods. The first is the 1920s, when newly independent Finland agreed to the migration of large groups
Background: Interventions in the form of animal-assisted and nature-based activities are promising for young adults with autism, but there is a knowledge gap concerning the long-term values of these. Aim: The aim was to describe the activity levels in daily life and socioeconomic aspects for young adults with autism one year after a 12-week intervention with animal-assisted and nature-based activi
Aim: To provide an overview of a project aimed at enhancing person-centred surgical care through teamwork and professional development. Design: A discursive paper with the purpose of describing and discussing the project activities to strengthen person-centred care, teamwork and professional development. Methods: This project aimed to strengthen evidence-based surgical nursing care within a Surger
Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) demands prompt mechanistic clarification. Early integration of coronary CT angiography (CCTA) and cardiovascular magnetic resonance (CMR) can refine diagnosis during the acute phase. Methods: Twenty-one consecutive patients (41 ± 10 years; 71% men) presenting with troponin-positive chest pain and unobstructed coronar
Great investments are planned in the north of Sweden the coming years, not the least in the county of Norrbotten where the projects collectively are referred to as the green transition due to the focus on fossil-free techniques. But to be able to secure a sustainable energy supply and reach the goal set by the member states of the European Union of a carbon dioxide neutral union in 2050 the produc
Den utländska prostituerade kvinnan har under drygt 100 år gått från att utvisas på grund av sin asocialitet till att i dag betraktas som ett offer. En utveckling som skett över lång tid där lagstiftarens och samhällets syn på problemet påverkat varandra om vartannat. Ett tydligt ställningstagande presenterades från statens sida när en kriminalisering av sexköp infördes år 1999. Prostitutionen varThe foreign prostitute has, over a period of more than 100 years, transitioned from being deported due to her antisocial behavior to being regarded as a victim today. This development has taken place over an extended period, where the perspectives of legislators and society have alternately influenced each other. A clear stance was taken by the state when the criminalization of sex purchase was in
