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Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov
Introduction: Obesity is a chronic, progressive, and recurring disease that contributes significantly to multimorbidity across Europe. Despite the publication of numerous clinical practice guidelines (CPGs) for obesity, many chronic disease guidelines for obesity related diseases such as diabetes, MASLD, heart disease, obstructive sleep apnea do not integrate contemporary understandings of obesity
Accessible design enables participation in the digital society for everyone. However, cognitive accessibility is not well established within the field of web design. The International Classification of Functioning, Disability and Health (ICF) provides a descriptive framework that relates health conditions to functioning and participation. ICF Core Sets are purposefully tailored shortlists of ICF c
To predict major pressure losses from pumping shear thinning liquid foods and beverage, rheometer-measured flow behaviour (n) and flow consistency (K) indices are needed. These are always obtained with some measurement uncertainty. This contribution develops a tool that allows for quantitatively estimating how a given measurement uncertainty in the rheological parameters translate to predictio
Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de
STUDY QUESTION What are the perspectives of oocyte and sperm donors 14-17 years post-donation on the release of their identity and potential contact with donor-conceived offspring (DCO)? SUMMARY ANSWER Most oocyte and sperm donors wanted to be notified about future releases of their identity and were positive towards contact with DCO, but more than half expressed a need for support in relation to
BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl
Vacuum membrane distillation is a promising technology for seawater desalination, as it enables high recovery ratios, with reasonable thermal and minimal electric consumption. Ceramic membranes can offer notable advantages over polymeric membranes, mainly due to their robust thermal and mechanical stability, yet they have limited representation in the literature. Accordingly, this work investigate
Climate change is one of the major drivers of biodiversity loss. Among vertebrates, amphibians are one of the more sensitive groups to climate change due to their unique ecology, habitat requirements, narrow thermal tolerance and relatively limited dispersal abilities. We projected the influence of climate change on an endemic toad, Malabar Tree Toad (Pedostibes tuberculosus; hereafter MTT) from t
Facilitated CO stripping: Partial metallization of TiO2 nanoparticles (NPs) by electroreduction in the molten, eutectic mixture of CaCl2 and NaCl at 600 °C produces nano- and submicro-sized Ti2O and CaδTiOx (perovskites, x/× δ 2) that can significantly promote the catalytic activity of Pt NPs towards the oxidation of CO and CH3OH in acidic solutions
The browning of freshwater ecosystems is increasingly evident in temperate and northern regions, with widespread ramifications for lake physics, chemistry, and biology. Contrasting results on how freshwater browning may impact fish have been reported, but there has been no comprehensive examination of how browning may cause cascading effects on individual- to population- to community-level traits
The governance of agricultural resources, particularly seeds, has long been a site of contestation between corporate-aligned institutions promoting proprietary seed laws and smallholder farmers, civil society organisations, and food sovereignty advocates defending traditional seed systems and local control. In Ghana, the introduction and eventual passage of the Plant Variety Protection Act of 2020
The purpose of this thesis is to analyze how the ongoing controversy surrounding the Internet, the phenomena of digitalization and file sharing will affect the music industry in the form of the “big five“ labels. Furthermore the thesis aims to present a recipe of strategies for the companies’ survival by studying their situation through a theoretical perspective in conjunction with a comparative a
I dagens högteknologiska, demokratiska samhälle där information kan spridas och tas fram på ett par sekunder och där yttrande- och tryckfrihetsrätten har en central roll blir den personliga integriteten sårbar. Samhället har genom målsättningsstadgandet i 1 kap. 2 § fjärde stycket Regeringsformen (1974:152) om att det allmänna skall värna den enskildes privatliv slagit fast att den enskildes integ
År 2015 meddelades en dom från Högsta domstolen som medförde att sexualbrott inte längre ses som egenhändiga brott. Ett sexuellt övergrepp kan således begås på distans, där offret utför den sexuella handlingen på sig själv. Våren 2016 prövades i tingsrätt frågan om även våldtäkt mot barn kunde begås på distans. Övergreppen bedömdes dock istället som sexuellt övergrepp mot barn. Uppsatsen syftar tiIn 2015 the Supreme Court announced that a perpetrator of a sexual offence no longer has to perform the sexual act in person to be held accountable for the deed. Thus, sexual assault can be committed when a child is coerced into performing a sexual act on themselves. During the spring of 2016 the question whether a perpetrator, based on the statement from the Supreme Court, could be held responsib
Barnäktenskap och tvångsäktenskap är sedvänjor som globalt betraktas som skadliga och därför aktivt motarbetas av det internationella samfundet. I svensk rätt anses äktenskapet vara en angelägenhet för de berörda individerna och åldersgränsen för ingående är 18 år. Ett utländskt barnäktenskap där någon av parterna har anknytning till Sverige erkänns inte. Ett barnäktenskap utan sådan anknytning erChild marriages and forced marriages are customs that are globally regarded as harmful and therefore actively opposed by the international community. In Swedish law, marriage is a matter for the concerned individuals only and the age limit for entering a marriage is 18 years. A child marriage originating in a foreign country is not recognized in Sweden if any of the spouses has ties to Sweden. A f
Syftet med detta examensarbete har varit att undersöka den processuella gången som följer då poliser begår våldsbrott i tjänst. Förfarandet innebär processer i flera instanser vilket leder till en rad problem, inte minst ur ett rättssäkerhetsperspektiv. Målet har varit att undersöka förfarandet så som det ser ut idag, att identifiera eventuella problem och att söka lösningar på dessa. Polisens aThe aim of this master thesis has been to examine the court proceedings when policemen commit violent crimes at work. The procedure involves processes in multiple instances causing a range of problems. The goal has been to investigate the procedure as it is today, to identify potential problems and to seek solutions to these problems. The police has a complex role in society and their work assig
Bakgrund: Våld i nära relation utgör ett folkhälsoproblem samt är en kränkning av mänskliga rättigheter. Mödrahälsovården i Sverige är ålagd att rutinmässigt fråga gravida kvinnor om våldsutsatthet. Tidigare forskning visar att mödrahälsovårdsbarnmorskan kan uppleva ett flertal hinder mot att ställa frågan. Våldsutsatta gravida kvinnor drabbas oftare av obstetriska komplikationer som kräver sluten
