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Although the beneficial effect on breast cancer of adjuvant tamoxifen (TAM) is well established, in the series studied by our group this effect seems to have been restricted to patients with steroid receptor (especially progesterone receptor (PgR)) positive tumors. However, as some patients with PgR-positive tumors manifested recurrence despite adjuvant TAM treatment, the question arose whether so
Fluorescence in situ hybridization (FISH) with a locus-specific dual DNA probe (LSI EGR-1SO/D5S23SG) for chromosome 5 was used in combination with morphology to study bone marrow cell lineage involvement of the abnormal chromosomal clone in 13 patients with deletion 5q[del(5q)], either as a sole aberration or as part of a complex karyotype, and in six cases with monosomy 5 by metaphase cytogenetic
The photoreceptor cells of the nocturnal spider Cupiennius salei were investigated by intracellular electrophysiology. (1) The responses of photoreceptor cells of posterior median (PM) and anterior median (AM) eyes to short (2 ms) light pulses showed long integration times in the dark-adapted and shorter integration times in the light-adapted state. (2) At very low light intensities, the photorece
Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-b
The reported rate of detection of Chlamydia pneumoniae DNA within atherosclerotic lesions by PCR varies between 0 and 100%. In this study, identical sets of coded experimental atheroma samples (n = 15) and spiked controls (n = 5) were analyzed by 16 test methods in nine centers by means of PCR. The positive controls were correctly identified to levels of 1, 0.1, and 0.01 inclusion bodies of C. pne
A new system for photon induced fluorescence spectroscopy (PIFS) at the gas phase photoemission beamline (Elettra, Trieste) is described. It consists of a novel non-dispersive detector for VUV photons and a spectrometer for UV/visible light with cooled CCD detector. To illustrate the performance of the apparatus, the fluorescence decay of the doubly excited states of helium below the N = 2 ionizat
Although the systemic changes towards innovation networking between university-industry and governmental actors have recently found a place on the international policy and literature agenda, networking between the organizations and people - for the national survival, production and growth - has been deeply rooted in the Israeli system even before the establishment of the Israeli State in 1948. Int
An automated system was developed for analysis of non-polar and polar ionisable compounds at trace levels in natural water. Sample work-up was performed in a flow system using two parallel membrane extraction units. This system was connected on-line to a reversed-phase HPLC system for final determination. One of the membrane units was used for supported liquid membrane (SLM) extraction, which is s
Neural transplantation is an experimental treatment for Parkinson's disease. Widespread clinical application of the grafting technique is hampered by a relatively poor survival (around 10%) of implanted embryonic dopamine neurones. Earlier animal studies have indicated that a large proportion of the grafted cells die during graft tissue preparation and within the first few days after intracerebral
There is a strong interest in use of `smart polymers' in separation systems. These are polymers which can react on external influence, such as temperature or pH change. With such polymers it is possible from the outside to affect the properties of a separation system. Amphiphilic copolymers show drastic changes in solubility properties, such as self-association and phase separation, at e.g. temper
In this chapter, we focus on one element of the fragmentation of global climate governance, namely the overlap between the UN climate regime and the World Trade Organization (WTO). With a view to the appraisal question for the ‘architecture’ theme of this volume, we hold that this overlap not only implies benefits, but may also entail significant drawbacks for the development and implementation of
A statistical distribution for the number of CDMA RAKE fingers, N T, to be assigned in order to track a given percent of the total received power has been derived. The obtained distribution reveals a strong dependence of NT on the system bandwidth, the median RMS delay spread, its standard deviation and other environment specific parameters. Also, a statistical distribution for the fading width fw
A virtual reality (VR) experiment with 96 participants was carried out in a Cave Automatic Virtual Environment (CAVE) laboratory at Lund University to provide recommendations on the design of flashing lights at emergency exit portals for road tunnel emergency evacuation. A set of variables were investigated, namely 1) Colour of flashing lights, 2) Flashing rate, 3) The type of light source, 4) The
In this thesis computationally intensive methods are used to estimate models and to make inference for large, spatio-temporal data sets. The thesis is divided into two parts: the first two papers are concerned with video analysis, while the last three papers model and investigate environmental data from the Sahel area in northern Africa. In the first part of the thesis, mixture models are used to
