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Air pollution research has been conducted in Europe and North America as well as in Asia and South America for decades, but there has, so far, only been a limited amount of studies on air pollution and its health effects conducted in Africa. Until recently, global inventories of pollutants from North America Europe and Asia have been used for air quality and climate change modelling in Africa (Bon
During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv
NMR spectroscopy provides valuable data for metabolomics, but the information sought can be partly obscured by errors from hardware imperfection, causing frequency, phase, and spectral lineshape to change significantly between measurements. Clearly, this is a highly undesirable source of variation in multivariate quantitative studies such as metabolomics. Fortunately,
Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1
As policymakers and scholars evaluate possible ways forward in the reform and renewal of public services by governments caught up in a recessionary environment, this book aims to offer something different – a comprehensive analysis of the development of the ‘Scandinavian’ way of modernizing public-sector management. No book has yet provided an inside view of the development and character of New PuAs policymakers and scholars evaluate possible ways forward in the reform and renewal of public services by governments caught up in a recessionary environment, this book aims to offer something different – a comprehensive analysis of the development of the ‘Scandinavian’ way of modernizing public-sector management. No book has yet provided an inside view of the development and character of New Pu
The mobilisation of psychologists in Sweden working for lesbian, gay, bisexual, trans* and queer (LGBTQ) wellbeing and rights has so far not succeeded in creating continuity despite several attempts to establish some kind of organisation since the mid 1990s. A new attempt was made in 2013 when the Swedish LGBTQ network for psychologists was formed following a formal decision at the congress of the
Conflicts over wildlife and their potential impacts on human practices and livelihoods are widespread. Large carnivore predation on livestock often becomes a contested topic which has led to global declines in carnivore numbers over centuries. To minimise impacts of carnivores on human livelihoods and allow conservation, various interventions are used to prevent attacks. However, these interventio
In light of the speedy technological development in society, technical standards are becoming increasingly important. In the early days, the specific tasks delegated to standardization bodies under the New Approach did not attract much political interest. Today, however, politicians and different stakeholders realize that the tasks delegated to the standardization industry are highly important for
Mantle cell lymphoma (MCL) is an aggressive malignancy and new treatment modalities must be established to increase patient survival time. In the search for new therapeutic targets, reliable and well-characterised in vitro models are essential. In this study, we have characterised three MCL cell lines (SP53, Granta 519 and NCEB1) in comparison with primary tumors front MCL, follicular lymphomas (F
Detta examensarbete var en del i ett forskningsprojekt som utfördes vid avdelningen för maskinkonstruktion vid Lunds tekniska högskola och gick ut på att studera hur metodiken kring produktutveckling används hos ett antal företag i praktiken och jämföra detta med metodiken från litteraturen och det som lärs ut vid Lunds tekniska högskola, för att identifiera brister i modellerna och fungera som etThis Master´s Thesis is part of a larger research project carried out at the Division of Machine Design, Department of Design Science, LTH, and is about studying the product development methodologies applied in the industry and compare these to the methodologies described in the literature and taught at LTH. The first part of the assignment consisted in studying the existing methodologies about pr
After having received criticism during previous inter-governmental conferences the European union decided to arrange a convention on the future of europe during 2002 in order to draft a European constitution. This was done to foremost to improve the transparency, participation and decision-making in the preparatory phase of inter-governmental conferences. At first, it received little attention, bu
