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We propose a new model that estimates the long- and short-run components of the variances and covariances. The advantage of our model to the existing DCC-based models is that it uses the same form for both the variances and covariances and estimates these moments simultaneously. We apply this model to obtain long- and short-run factor betas for industry test portfolios. We find that the risk premi

Background & Aims: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. Methods: The association of 92 f

Purpose: Distal cholangiocarcinoma and pancreatic ductal adenocarcinoma are malignancies with poor prognoses that can be difficult to distinguish preoperatively. Thrombospondin-2 has been proposed as a novel diagnostic biomarker for early pancreatic ductal adenocarcinoma. The aim of the present study was to evaluate thrombospondin-2 as a diagnostic and prognostic biomarker in combination with curr

This article seeks to provide a new analytical framework based on factor endowments to understand growth in rural economies without structural transformation. More concretely, it explores the variation in farmers’ ability to respond to new commercial opportunities. To complement the extensive literature on the economic and institutional effects of factor endowments, this paper revisits two influen

Background: The presence of noise is problematic in the analysis and interpretation of the ECG, especially in ambulatory monitoring. Restricting the analysis to high-quality signal segments only comes with the risk of excluding significant arrhythmia episodes. Therefore, the development of novel electrode technology, robust to noise, continues to be warranted. Methods: The signal quality of a nove

Multi-cluster federation is envisioned to be the next-generation cloud infrastructure, where it will play a vital part in the realization of concepts such as edge and fog computing. Orchestrating applications in federated environments poses new challenges to well-known research problems in various fields, such as load-balancing, auto-scaling, resource allocation and service migration. However, as

We explore the fundamental relations governing the radial and vertical velocity dispersions of stars in the Milky Way, from combined studies of complementary surveys including GALAH, LAMOST, APOGEE, the NASA Kepler and K2 missions, and Gaia DR2. We find that different stellar samples, even though they target different tracer populations and employ a variety of age estimation techniques, follow the

Personalized case conceptualization is often regarded as a prerequisite for treatment success in psychotherapy for patients with comorbidity. This article presents Perceived Causal Networks, a novel method in which patients rate perceived causal relations among behavioral and emotional problems. First, 231 respondents screening positive for depression completed an online Perceived Causal Networks

Background: In pediatric palliative care (PPC), there is a need to involve the child’s voice in situations regarding their symptoms and care needs. Patient-reported outcome measures (PROMs) can be tools to systematically gather data reported from the child or a proxy if the child is not capable to self-report in order to provide the services they need. There has been a rapid development in PROM re

The longevity of the almost 100-year-old Ålandic autonomy has been attributed to, among other things, its ability to evolve and adapt to changing circumstances. This position can be problematized and qualified in at least four ways: firstly, most initiatives to develop the autonomy have come from the Ålandic and not the Finnish side; secondly, the processes leading up to the adoptions of new Auton

BACKGROUND: Contemporary patients with primary hyperparathyroidism are often diagnosed with mildly raised serum calcium levels. Previous studies have reported increased mortality in patients with primary hyperparathyroidism. This retrospective cohort study aimed to examine whether contemporary patients operated for primary hyperparathyroidism have higher mortality than the general population, and

Translation is controlled by numerous accessory proteins and translation factors. In the yeast Saccharomyces cerevisiae, translation elongation requires an essential elongation factor, the ABCF ATPase eEF3. A closely related protein, New1, is encoded by a non-essential gene with cold sensitivity and ribosome assembly defect knock-out phenotypes. Since the exact molecular function of New1 is unknow

An integrated flat-flame/ microprobe sampling quadrupole mass spectrometer system, complemented by optical spectrometry based on optical fibers, is presented. The short microprobe sampling line (total 25 cm) is directly connected to an open ion source closely flanked by two nude cryopumps (900 l/s) yielding a background pressure of 10-9 Torr and a sampling pressure of about 10-5 Torr. Due to this

A novel life-cycle assessment (LCA) model has been developed for the investigation of the environmental impact of the choice of material in cable production. In the first application polyolefin based material and PVC material is used. In both cases equivalent fire behaviour is assumed and a fire model is established based on existing fire statistics. This study represents the second full applicati

Ever since the international financial crisis of 2007/08, Sweden stands out as a country with a prudent and sustainable national debt policy. Debt rises during recessions and crises only to fall back during times of growth. A low debt level before a major crisis allows Sweden to increase its public debt and support the economy during a crisis without risking a fiscal crisis. The strength of the Sw

In this paper we derive error estimates of the backward Euler–Maruyama method applied to multi-valued stochastic differential equations. An important example of such an equation is a stochastic gradient flow whose associated potential is not continuously differentiable but assumed to be convex. We show that the backward Euler–Maruyama method is well-defined and convergent of order at least 1/4 wit

In this paper we conduct a multi-criteria analysis (MCA) from a multiple stakeholder point of view for the design of access and benefit sharing (ABS) agreements concerning genetic resources, in particular regarding the access component of such agreements. We start by analyzing the objectives defined by international law (viz. the Convention on Biodiversity and the Nagoya Protocol) that every party

This article describes how a wheel–rail wear detection parameter based on noise was developed by running a rapid transit train instrumented with microphones in a depot with a small curve radius. This full-scale test made use of previous knowledge gained from lab-scale tests. The lab- and full-scale tests showed that noise could be used as an indicator of wear transition, when normal wear turns int