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The introduction of Rituximab has greatly improved therapeutic options for patients with B-cell non-Hodgkin lymphoma (B-NHL). However, a substantial fraction of patients with aggressive B-NHL fails first-line therapy, and most patients with relapsing indolent B-NHL eventually acquire Rituximab resistance. Molecular understanding of the underlying mechanisms facilitates the development of pharmacol
In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA) neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic tissue have shown that grafted DA neurons reinnervate the striatum, restore striatal DA release and, in some patients, induce major clinical benefit. Stem cells could provide an unlimited source of DA neurons for trans
The investigation of periodic motions of constrained multibody systems requires the numerical solution of differential-algebraic boundary value problems. After briefly surveying the basics of periodic motion analysis the paper presents an extension of projected collocation methods [6] to a special class of boundary Value problems for multibody system equations with position and velocity constraint
Fuel cells are promising with advantages of higher energy conversion efficiency and lower emissions of SOX, NOX, and CO2 than conventional power systems. Solid oxide fuel cell (SOFC) is a high temperature fuel cell, which operates at 873-1273 K. This allows SOFCs to operate with different types of fuels from both fossil and renewable sources because of their general higher tolerance to contaminant
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 co
Recently, a novel laser imaging technique, structured laser illumination planar imaging (SLIPI), has demonstrated great potential for suppressing multiply scattered light in spray imaging. SLIP! uses a laser sheet whose intensity is modulated in the spatial domain. Directly scattered photons keep this structural information; whereas, photons that experienced several scattering events lose this inf
Background: Little is known about the development of excess skin and requests for body-contouring surgery after bariatric surgery in adolescents. Methods: Forty-seven of 86 adolescents that had undergone gastric bypass surgery answered two questionnaires regarding excess skin and requests for and performed body-contouring surgery. An objective assessment of the amount of excess skin was also perfo
We present here an innovative, fluorescent, monoolein-based cubosome dispersion. Rather than embedded within the monoolein palisade, the fluorescent imaging agent, namely dansyl, was conjugated to the terminal ethylene oxide moieties of the block copolymer Pluronic F108. We discuss the physicochemical and photophysical properties of this fluorescent Pluronic and of a cubosome formulation stabilize
The purpose of this study was to examine the relation between poor sleep and nonsuicidal self-injury (NSSI), and to test the hypothesis that poor sleep is a risk factor for the development of NSSI in young adolescents. Questionnaire data were used from a 2-wave longitudinal study of a community sample of 881 young Swedish adolescents. The results showed that 7 % of the girls reported poor sleep (n
Background: Long-term care for stroke survivors is fragmented and lacks an evidence-based, easy-to-use tool to identify persistent long-term problems among stroke survivors and streamline referral for treatment. We sought to develop a poststroke checklist (PSC) to help health care professionals identify poststroke problems amenable to treatment and subsequent referral. Methods: An instrument devel
The problem of optimum load control of steam power plants has been dealt within many technical papers during the last decades. Deregulation of the power markets and close to the (bio-) fuel source thinking has lead to a trend of small scale combined heat and power plants. These plants are usually operated according to the heat demand and therefore they spend a significant time on partial load. The
While good physiological models of the glucose metabolism in type 1 diabetic patients are well known, their parameterisation is difficult. The high intra-patient variability observed is a further major obstacle. This holds for data-based models too, so that no good patient-specific models are available. Against this background, this paper proposes the use of interval models to cover the different
Abstract in UndeterminedFew studies have investigated long-term odor recognition memory, although some early observations suggested that the forgetting rate of olfactory representations is slower than for other sensory modalities. This study investigated recognition memory across 64 days for high and low familiar odors and faces. Memory was assessed in 83 young participants at 4 occasions; immedia
We employ the optimal orthogonal portfolio approach to investigate if the size and book-to-market effects in US data are related to risk factors beside the market risk. This method enables us to estimate the upper limit of the risk premium, due to observed as well as all possible unobserved factors, which can be derived from a linear asset pricing model. As a corollary, it is possible to divide th
When using a reduced ECG lead system with three leads or less, the analysis of atrial activity during arrhythmias can become problematic due to low signal amplitude and noise. Long ago, Sir Thomas Lewis proposed a lead system for atrial activity enhancement in which two electrodes are placed directly on the chest, however, these leads are sensitive to arm movement artifacts. In this study, a modif
Biosynthetic nerve grafts are desired as alternative to autologous nerve grafts in peripheral nerve reconstruction. Artificial nerve conduits still have their limitations and are not widely accepted in the clinical setting. Here we report an analysis of fine-tuned chitosan tubes used to reconstruct 10 mm nerve defects in the adult rat. The chitosan tubes displayed low, medium and high degrees of a
This paper presents a Sorted QR-Decomposition (SQRD) processor for 3GPP LTE-A system. It achieves energy efficiency by co-optimizing techniques, such as heterogeneous processing, reconfigurable architecture, and dual-supply voltage operation. At algorithm level, a low-complexity hybrid decomposition scheme is adopted, which switches, depending on the energy distribution of spatial channels, betwee
