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A spin-echo-modulated small-angle neutron scattering (SEMSANS) instrument in a time-of-flight (TOF) mode will be able to excel at pulsed neutron sources such as the European Spallation Source (ESS), currently under construction. This work compares experimental data from a TOF SEMSANS setup, where a spatial beam modulation of a white beam is obtained using triangular field coils, with Monte Carlo r
The importance of predation risk in shaping patterns of animal migration is not well studied, mostly owing to difficulties in accurately quantifying predation risk for migratory versus resident individuals. Here, we present data from an extensive field study, which shows that migration in a freshwater fish (roach, Rutilus rutilus) that commonly migrates from lakes to streams during winter confers
Antibiotic resistance (AR) poses an ever growing threat to global public health. Methods are urgently needed that simplify and accelerate the clinical detection and classification of AR. Here we describe a function-based antibiotic resistance assay (FARA) biosensing strategy. The scheme comprises three key components: i) FARA directly measures the thermal signal generated from the catalytic break-
Both environmental and genetic factors can dramatically affect reproductive performance in mice. In this study we have focused on the identification of genetic regions, quantitative trait loci (QTL), which affect the breeding capacity of female mice. We have identified polymorphic microsatellite markers for the mouse strains used and performed a genomewide scan on 237 females from a gene-segregati
We propose a method for efficient storage and recall of arbitrary nonstationary light fields, such as, for instance, single photon time-bin qubits or intense fields, in optically dense atomic ensembles. Our approach to quantum memory is based on controlled, reversible, inhomogeneous broadening and relies on a hidden time-reversal symmetry of the optical Bloch equations describing the propagation o
A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodologica
We present the computer program HYBRIDLAB 1.0 for simulating intraspecific hybrids from population samples of nuclear genetic markers such as microsatellites, allozymes or SNPs ( single nucleotide polymorphisms). The program generates a user-specified number of multilocus F1 hybrid genotypes between any pair of potentially hybridizing populations included in a standard input-file of multilocus gen
The limitations of a pseudo-transient approach for modeling temperature wave propagation in district heating pipes were investigated by comparing numerical predictions with experimental data. The performance of two approaches, namely a pseudo-transient approach implemented in the finite element code ANSYS and a node method, was examined for a low turbulent Reynolds number regime and small velocity
Human neutrophils are activated by the beta-galactoside-binding lectin galectin-3, provided that the cells are primed by in vivo extravasation or by in vitro preactivation with, for example, LPS. Removal of terminal sialic acid can change neutrophil functionality and responsiveness due to exposure of underlying glycoconjugate receptors or change in surface charge. Here, we investigated whether suc
Background: Sentinel node biopsy (SNB) is a standard staging procedure in early breast cancer. Its suitability for larger tumours has been questioned. This study evaluated the reliability of SNB in women with invasive breast cancer larger than 3 cm in diameter who were clinically axillary node negative. Methods: Some 109 women with a turnout larger than 3 cm on pathological analysis were identifie
This paper presents a new fast approach to improving stability in polynomial equation solving. Gröbner basis techniques for equation solving have been applied successfully to several geometric computer vision problems. However, in many cases these methods are plagued by numerical problems. An interesting approach to stabilising the computations is to study basis selection for the quotient space C[
The aim was to test the hypothesis that the human leucocyte antigen (HLA) haplotype that is not inherited from the mother, that is, the non-inherited maternal antigen (NIMA) affects the risk for type 1 diabetes (T1D). A total of 563 children with T1D and 286 non-diabetic control children from Sweden were genotyped for DRB1, DQA1 and DQB1 alleles. The frequency of positively (DR4-DQA1*0301-B1*0302
Mikhlin's method for solving Laplace's equation in domains exterior to a number of closed contours is discussed with particular emphasis on the Dirichlet-Neutnann map. In the literature there already exit tyro computational modes for Mikhlin's method. Here a new mode is presented. The new mode is at least as stable as the previous modes. Furthermore, its computational complexity in the number of c
Evidence for the importance of genetic factors in male fertility is accumulating. In the literature and the Mendelian Cytogenetics Network database, 265 cases of infertile males with balanced reciprocal translocations have been described. The candidacy for infertility of 14 testis-expressed transcripts (TETs) were examined by comparing their chromosomal mapping position to the position of balanced
Optical pump-terahertz probe spectroscopy has become a widely used experimental tool for the investigation of the ultrafast far-infrared response of polar systems. In this paper the authors present an analytical method of calculating the propagation of ultrashort terahertz pulses in photoexcited media. The transient terahertz wave form transmitted through the sample is equal to a product of the in
A recently introduced silicon microextraction chip (SMEC), used for on-line proteomic sample preparation, has proved to facilitate the process of protein identification by sample clean up and enrichment of peptides. It is demonstrated that a novel grid-SMEC design improves the operating characteristics for solid-phase microextraction, by reducing dispersion effects and thereby improving the sample
HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict c
Acoustic standing wave technology combined with microtechnology opens up new areas for the development of advanced particle and cell separating microfluidic systems. This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems. The transition to the microchip format is further surveyed, where both fabrication
