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GPR30, or G protein-coupled estrogen receptor (GPER), is a G protein-coupled receptor (GPCR) that is currently attracting considerable attention in breast cancer and cardiometabolic regulation. The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. However, questions remain about both the cognate ligand and the subcellular localization of receptor
BACKGROUND: Leptospirosis, caused by spirochetes of the genus Leptospira, is one of the most widespread zoonoses worldwide. Efficient diagnostic methods for early diagnosis of leptospirosis are still lacking, and acute disease presents with nonspecific symptomatology and is often misdiagnosed. The leptospires pathogenic processes and virulence mechanisms remain virtually unknown. In severe infecti
Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the peroxide regulator PerR, in an M1 serotype of Streptococcus pyogenes. To determine the role of PerR in S. pyogenes, we inactivated the gene by allelic replacement. PerR-deficient bacteria showed 48% reductio
Background and Objectives. Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells. It is involved in a number of physiologic and pathologic events including adhesion, angiogenesis, apoptosis, inflammation, wound healing and tumor metastasis. We wanted to investigate the potential role of OPN in multiple my
Klimatförändringarna tvingar miljontals människor världen över att lämna sina hem, men det juridiska skyddet för dem som flyr miljörelaterade kriser är fortfarande otydligt och fragmenterat. 1951 års flyktingkonvention erbjuder viktiga skydd för personer som flyr förföljelse, men omfattar inte individer som fördrivs av klimatförändringar, vilket skapar betydande luckor i den internationella rättenClimate change is displacing millions globally, yet legal protections for those fleeing environmental crises remain unclear and fragmented. The 1951 Refugee Convention offers critical safeguards for those fleeing persecution but excludes individuals displaced by climate change, leaving significant gaps in international law. This raises pressing questions: How can international law address the chal
During the last decade research in the scientific domain of information systems (IS) in corporate mergers and acquisitions (M&As) has become increasingly popular. A not very surprising development regarding the significance of the empirical phenomenon of M&A and the importance of IS for modern business. However, the idea of IS playing an important role in M&As rests on assumptions, ane
Summary Corporate acquisitions are negotiated during several occasions. If an agreement has not been met, the Swedish sale of goods act is applicable between the parties. The act indicates that the buyer has a duty to investigate the targeted company should the buyer invoke errors therein. An assessment of errors is based on the buyer’s reasonable expectations of the targeted company. The buyer caSammanfattning Överlåtelser av företag är betydelsefulla affärshändelser med förhandlingar i flera omgångar. När inget annat är avtalat tillämpas köplagen som föreskriver en plikt för köparen att undersöka målbolaget, annars riskeras rätten att kunna åberopa fel gå förlorad. Felbedömningen tar utgångspunkt i köparens befogade förväntningar på målbolaget och som fel får inte åberopas vad som borde
Abstract Title: Public-Private Partnership in Sustainable City Development Authors: Malin Olofsson, Maryna Pouzhyk, Vera Koreneva, and Quinn Ertel Tutor: Stein Kleppestø – Associate Professor, Department of Business Administration, Lund University Background: E.ON and Malmö have formed a Public-Private Partnership to lead the sustainable city development initiative in Hyllie. The green field de
This thesis aims to contribute to the field of time controlled charge and energy transport in mesoscopic systems. In Chapter 1, Chapter 2 and Chapter 3 a short review of the scattering matrix theory is presented, including both charge and energy transport, useful to understand the mathematical landscape used in Papers I, II, III and IV. Chapter 3 briefly presents the thermoelectric properties of m
