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Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. This project aimed

Det här examensarbetet innefattar framtagningen av ett verktyg som hjälper produktutvecklare designa ergonomiska produkter. Många produkter som idag når tillverkning, eller till och med marknaden, är inte alltid så ergonomiska som det hade kunnat önskas. Emellertid kan dessa problem förebyggas i ett tidigt skede genom väl genomtänkt utformning på produkter och adekvata ergonomiska utvärderingar. DThis master thesis consists of the development of a tool which helps product developers design ergonomic products. Many products which end up being manufactured, or end up on the market, are not as well thought out as one could wish. However, this problem can be prevented at an early stage by well thought out designs and adequate evaluations. This was a topic discussed with Avalon Innovation Techn

CT scanning stands as one of the most employed imaging techniques used in clinical field. In the presence of metal implants in the field of view (FOV), distortions and noise appear on the 3D image leading to inaccurate bone segmentation, often required for surgery planning or implant design. In this research project, we focused on developing a pipeline to create a rich ground truth dataset, formin

Accurate calibration is essential for reliable polarimetric measurements in frequency-domain terahertz ellipsometry. In this thesis, we investigate how different sets of calibration samples influence the quality of the extracted 4×4 Mueller matrix in an in-house built terahertz Mueller Matrix Ellipsometer operating in the 170-250 GHz range. Three calibration sets composed of various combinations o

Denna uppsats behandlar diskrimineringsrättens förbud mot bristande tillgänglighet i arbetslivet och analyserar hur långt arbetsgivarens skyldighet att vidta anpassningsåtgärder för arbetstagare med funktionsnedsättning sträcker sig. Med utgångspunkt i en rättsdogmatisk metod undersöks gällande rätt genom analys av svensk diskrimineringslagstiftning, EU-rätt, internationella åtaganden enligt FN:s This thesis examines the prohibition of lack of accessibility under discrimination law in working life and analyses the extent of employers’ obligations to implement reasonable accommodation measures for employees with disabilities. Using a legal dogmatic method, the study analyses current law through Swedish discrimination legislation, EU law, international obligations under the UN Convention on

Håldäckselement i betong är ett vanligt förekommande byggelement i Nordeuropa. Det är materialeffektiva element som tillverkas i fabrik med förspänd armering i underkant och ihåliga kanaler centrerat i tvärsnittet. Deras utformning och låga egenvikt bidrar till att möjliggöra långa spännvidder och flexibla planlösningar. Metoden för statisk dimensionering och lastkapaciteter finns dokumenterat och

This paper investigates the usability of the intelligence test Wechsler Nonverbal Scale of Ability (WNV). Twenty four children in two different age-groups were tested with WNV, 10 children between ages 5 - 6, and 14 children between ages 9 - 10. The WNV turned out to be a useful test when some verbal communication was used in the test situation. This was especially apparent among the younger child

Den här uppsatsen analyserar och jämför olika konflikttransformerande organisationer som verkat i Nordirland och genom detta ges möjlighet att på så vis ta reda på om det skett en konflikttransformation eller ej? Analysen utgår från John Paul Lederach teorier kring fredsbyggande modeller. Jag kommer använda mig av två modeller, den ena är en pyramid över samhället, där det politiska toppskiktet li

There is strong evidence that cognitive-behavioural therapy for insomnia (CBT-I) is effective. The aim of this study was to compare 7 group-sessions of mindfulness-based cognitive therapy for insomnia (MBCT-I) with 3 group-sessions of CBT-I, on sleep measures and sleep related psychological processes, such as pre-sleep arousal, thought control strategies and mindfulness. Participants (N = 44; age

Traditionally, international humanitarian organisations have used on-demand dispatch of disaster relief goods from regional logistics units (RLUs) for sudden onset disaster response. This paper investigates the improvements in efficiency and resilience of disaster relief operations by combining the existing method of onshore prepositioning of relief items in RLUs with offshore prepositioning of re

Differential cross sections (σ(Eγ,θn)) for the He(γ,n) reaction have been measured at Eγ=50–71 MeV and θn=30–120°. These data are compared with theoretical predictions where a microscopic calculation of the He and He wavefunctions has been made within the Alt-Grassberger-Sandhas, integral-equation formalism.

Relative population of states in 11B following the 12C(γ,p) reaction has been measured with high resolution using the deexcitation γ-ray technique. The states near 7 MeV in 11B are clearly resolved and the measured population clarifies earlier conflicting data. Comparison of the results with new calculations indicates the importance of both one-nucleon and multinucleon processes.

Aims: In this article we explore the moderators of effectiveness of WISEteens (Web-based brief Intervention for SubstancE using teens), a fully automated web-based brief motivational intervention targeting risky substance use among adolescents. Based on previous studies, we examined the differential effects on drinking of sex, readiness to change, self-efficacy, alcohol risk status, and parental m

Batch cultures with wheat straw, biomass of Paja Brava (Festuca orthophylla), filter paper, newspaper and beech leaves (Fagus sylvatica) were established to produce sulphide. Sulphide production, sulphate reduction, concentration of Volatile Fatty Acids (VFAs), enzyme activities and Fluorescence in situ hybridisation were determined. Approximately 5 mM of sulphide was produced during anaerobic dig

INTRODUCTION: Hypertension and dyslipidemia often precede cardiovascular disease. Lifestyle modifications help prevent these conditions, and referrals for women may be possible during reproductive health care visits. However, screening recommendations vary, which may affect screening rates. The objectives of this systematic review were to 1) assess the available literature on the effectiveness of