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Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to occur in type 1 diabetes, a complete understanding of the cell-to-cell interactions that support pancreatic function is still lacking. To characterize the pancreatic endocrine compartment, we stu
Polyethyleneimine (PEI) is an organic polycation used extensively as a gene- and DNA vaccine delivery reagent. Although the DNA targeting activity of PEI is well documented, its immune activating activity is not. We recently reported that PEI has robust mucosal adjuvanticity when administered intranasally with glycoprotein antigens. Here we show that PEI has strong immune activating activity after
Drowning is the second global leading cause of unintentional injury death for children ages 1 to 14 years, and the fifth leading cause for people of all ages (excluding flood disasters and water transport incidents). Why is the risk of drowning so high? It is important to investigate existing situation: what are the reasons that create a danger, is there a main risk group, how the risk of drownin
When live theatre is broadcast in real time at cinemas around the world, there is a gap in the current terminology. ’Mediatised live’ is a new expression, established in this thesis, to name the media form which has revolutionised the way of experiencing live theatre by broadcasting theatre live to venues around the world. By asking the question ‘Is the need for liveness dying?’ this thesis invest
Problem description: The importance of the warehouse in the supply chain network is increasing and the overall efficiency of a supply chain is to a large extent determined in the warehouses. It is acknowledged that warehouse design is a complex task mainly due to the many relationships to other functions within the company. The complexity is further enhanced by many activities and parallel process
Halvledarindustrin har en form av immaterialrätter avsedd särskilt för dem: Kretsmönsterrätter. Dessa introducerades i USA 1984 i syfte att skydda den amerikanska halvledarindustrin från konkurrens från östra Asien, huvudsakligen Japan. Den ersatte principen om nationell behandling med den materiella ömsesidighetsprincipen, som är normen inom immaterialrätt. Detta tillät USA att tvinga andra ländeThe semiconductor industry has a sui generis IP type dedicated to it: the semiconductor topography right. This right was introduced in 1984 with the purpose of protecting the U.S. semiconductor industry from East Asian, mainly Japanese, competition. It replaced the principle of treatment on a national basis that is the norm in IP law with one of material reciprocity, which allowed the U.S. to stro
This research investigates global adoption and suitability of phased evacuation strategies in multi-purpose residential buildings, blending a review of 33 codes and standards in 11 nations with simulation-based analysis of 30 phased evacuation scenarios. Findings from the review reveal a varied level of importance of phased evacuation worldwide, with Europe, particularly the United Kingdom, showin
Nowadays, the number of people infected with HIV/AIDS keeps rising in many countries. How can this risk be managed in society is an issue that gains on relevance. This paper focuses on the topic, how risk is communicated to society in the case of HIV/AIDS in Germany. It also looks at what aspects are emphasized and if different social groups are represented. Two nation-wide campaigns in Germany fr
The performed study is a qualitative case study of the company Business Sweden. An inductive research approach has been used where we started by observing Business Sweden and subsequently applied suitable theories. The aim with the paper is to describe and analyze the aspects of management control in a multinational hybrid organization, by observing the process of centralizing the responsibility o
Objectives: To find variables associated with outcome following thrombolytic treatment for acute lower limb ischemia. Design: Re-analysis of a prospective multicentre study. Material and methods: One hundred and twenty-one patients with acute lower limb ischemia previously included in a randomised study comparing high- with low-dose thrombolysis were re-analysed ignoring the mode of lytic treatmen
There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less
Abstract While outcome studies in pediatric obesity have received considerable attention, research on different components of effective interventions remains limited. Little is known which psychological method (i.e., behavior modification, cognitive behavior therapy and family therapy) is most useful or how the choice of program delivery (group/individual) influences the intervention outcomes. Gro
Anaerobic digestion provides an array of positive environmental benefits such as reducing greenhouse gas emissions, replacing mineral fertilizers, producing renewable energy and treating waste. However, pitfalls in anaerobic digestion such as poor methane yields, process instability, process failure and regional shortages of feedstock have limited the full exploitation of the anaerobic digestion p
Infection with the human gastric pathogen Helicobacter pylori can give rise to chronic gastritis, peptic ulcer, and gastric cancer. All H. pylori strains express the surface-localized protein HpaA, a promising candidate for a vaccine against H. pylori infection. To study the physiological importance of HpaA, a mutation of the hpaA gene was introduced into a mouse-adapted H. pylori strain. To justi
In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as we
