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BACKGROUND: Continuous spike-wave during slow wave sleep syndrome (CSWS) and Landau-Kleffner syndrome (LKS) are two epileptic encephalopathies that present with neurocognitive regression, aphasia, and clinical seizures, typically presenting in children around five years of age. The pathophysiology of these conditions is not completely understood. Some studies suggest a common origin for both. No s
Background: Response to modern treatment strategies, which combine cytotoxic compounds with immune stimulatory agents and targeted treatment is highly variable among MCL patients. Thus, providing prognostic and predictive markers for risk adapted therapy is warranted and molecular information that can help in patient stratification is a necessity. In relapsed MCL, biopsies are rarely available and
INTRODUCTION: This study aimed to adapt the Short Digital Stress Scale (SDSS) into Turkish and to evaluate its psychometric properties in an adult population. Digital stress has become increasingly relevant with the widespread and continuous use of digital technologies, highlighting the need for valid and reliable instruments across cultural contexts.METHODS: A total of 276 adults (72.8% female, 2
BackgroundOsteocalcin is a bone-specific protein involving many physiological processes, primarily bone turnover. Also closely related to the musculoskeletal system is the frailty syndrome.AimTo investigate if circulating osteocalcin levels and frailty are associated in the old, and in addition, if the presumed association is mediated through alterations in bone.Methods999 community-dwelling women
Rapid urban growth is making cities hotter, a trend further exacerbated by climate change. Urban green spaces (UGS) are commonly used as nature-based solutions to reduce heat, but there are gaps in understanding how cooling effects vary across climate zones. Using satellite data from 2021 to 2024, we examined urban heat and UGS patterns during the hot season across four Ethiopian cities with diffe
PurposeThis study aims to assess the diffusion and integration of Circular Economy (CE) knowledge across academic disciplines, by examining how CE concepts spread within mainstream academic and disciplinary discourses.Design/Methodology/ApproachCE is conceptualized as a knowledge object, distinguishing between mainstream academic discourse (MAD) and mainstream disciplinary discourse (MDD). The res
BACKGROUND: Digital symptom checkers might help facilitate effective triage in primary healthcare. However, evidence regarding their acceptance among healthcare professionals remains limited. Identifying key factors of adoption is essential for successful integration into clinical practice.This study aims to identify factors most relevant to nurses' acceptance of a newly implemented digital triage
Ventricular function is vital in patients with single ventricles but repeated surgeries and changes in ventricular volume load may change the relation between longitudinal and radial function. To expand the knowledge of cardiac mechanics in this population, the aim of this study was to assess longitudinal and radial contribution to stroke volume using cardiac magnetic resonance (CMR) imaging in pa
Head Computed Tomography (CT) imaging is still a commonly obtained diagnostic test for patients with minor head injury despite availability of clinical decision rules to guide imaging use and recommendations to reduce radiation exposure resulting from unnecessary imaging. This prospective multi-center observational study of 251 patients with suspected mild to moderate traumatic brain injury (TBI)
Background: The link between squamous cell cervical carcinoma and human papillomavirus (HPV) 16/18 is well established, but the magnitude of the risk association is uncertain and the importance of other high-risk HPV (HRHPV) types is unclear. Methods: In two prospective nested case-control series among women participating in cytologic screening in Sweden, we collected 2,772 cervical smears from 51
Background: Available evidence suggest that perceptions or ratings of the neighborhood, e.g. as being green, walkable or noisy, are important for effects on health and wellbeing, also after controlling for objective measures of identical or similar features. When evaluating effects of the perceived environment, it is important that measurement properties and the reliability of the environmental ra
While many laboratory studies have focused on the short term effects of biochar addition to soil), there have been comparatively few tracing its longer term effects in the field. This study investigated the multiyear impact of biochar on crop performance and soil quality with specific emphasis on carbon (C) and nitrogen (N) cycling over a 3 y period. Biochar was added to an agricultural field at 0
The use of ground-source heat pumps for heating buildings and domestic hot water in dwellings is increasing rapidly in Sweden. The heat pump extracts heat from the ground by a U-pipe in a vertical borehole. In order to reduce the electricity demand in the system, the combination with solar collectors is introduced. This system may be designed in many ways and the advantages differ a lot. Solar hea
Acute cardiovascular events, most commonly caused by rupture of an atherosclerotic plaque, lie behind one third of all deaths worldwide. Atherosclerosis is an inflammatory disease of large and medium sized arteries driven by retention of lipid in the arterial wall. Inflammatory activity in the plaque is believed to be an important driving force behind plaque progression and rupture. However it is
Background: Sex pheromones are essential in moth mate communication. Information on pheromone biosynthetic genes and enzymes is needed to comprehend the mechanisms that contribute to specificity of pheromone signals. Most heliothine moths use sex pheromones with (Z)–11–hexadecenal as the major component in combination with minor fatty aldehydes and alcohols. In this study we focus on four closely
Objective The primary objective of this study was to assess the impact of atomoxetine in combination with psychoeducation, compared with placebo and psychoeducation, on health-related quality of life (HRQL) in Swedish stimulant-naive pediatric patients with attention deficit/hyperactivity disorder (ADHD). HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safet
Background: Many older adults are physically inactive and inactivity increases with age. This knowledge comes from cross-sectional studies. Cross-sectional studies may miss important trajectories within the older adults as a result of retirements, and poor health impact of promotional efforts. The aim of this study was to analyse, longitudinally, the annual effects of age group and birth cohort on
Renal function is often estimated using one of several glomerular filtration rate (GFR) estimating equations. However, there is no consensus which estimating equation performs best in patients with advanced renal failure. We compared the performance of five different estimated GFR (eGFR) equations [Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease (CKD) Epidemio
Land-use change is a major driver of the global loss of biodiversity, but it is unclear to what extent this also results in a loss of ecological traits. Therefore, a better understanding of how land-use change affects ecological traits is crucial for efforts to sustain functional diversity. To this end we tested whether higher species richness or taxonomic distinctness generally leads to increased
BACKGROUND/OBJECTIVES: Cross-sectionally, educational attainment is strongly associated with the prevalence of obesity, but this association is less clear for weight change during adult life. The objective of this study is to examine the association between educational attainment and weight change during adult life in the European Prospective Investigation into Cancer and Nutrition (EPIC). SUBJECT
