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Detrital zircon age and Hf isotope patterns for the Cahill Formation and Nourlangie Schist are distinctly different from other Paleoproterozoic successions in the North Australian Craton. The Cahill Formation and Nourlangie Schist comprise the bulk of the Paleoproterozoic strata in the Nimbuwah Domain, the easternmost part of the Pine Creek Orogen on the northern margin of the North Australian Cra
Several approaches to the use of health claims on foods have been made around the world, and the common theme is that any health claim will require scientific validation and substantiation. There is also broad consensus that any regulatory framework should protect the consumer, promote fair trade and encourage innovation in the food industry. This paper is based on a critical evaluation of existin
Background: Computed tomography (CT) lung densitometry has been demonstrated to be the most sensitive and specific outcome measure for the assessment of emphysema-modifying therapy, but the optimum densitometric index has yet to be determined and targeted sampling may be more sensitive than whole lung assessment. The EXAcerbations and CT scan as Lung Endpoints (EXACTLE) trial aimed to clarify the
Objectives. The EGFR is expressed in malignant ovarian tumor tissue, and tissue content of EGFR has been directly associated with poor prognosis in patients with ovarian cancer. The uPA system plays a role in pericellular proteolysis, cell migration, invasion, and is over-expressed in ovarian cancer. This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3.
Background: p21-activated kinase 1 (Pak1) phosphorylates many proteins in both normal and transformed cells. Its ability to phosphorylate and thereby activate the estrogen receptor alpha (ER alpha) potentially limits the effectiveness of antiestrogen treatment in breast cancer. Here we studied associations between Pak1 expression and subcellular localization in tumor cells and tamoxifen resistance
Popular Abstract in Swedish Denna avhandling undersöker dagvatten som en resurs i svensk urban miljö. Fokus har varit öppna dagvattensystem för flödeskontroll och uppsamlingssystem för regnvatten. För att analysera realiserandet av öppna dagvattensystem, presenteras två fallstudier; Augustenborg i Malmö och Bäckaslöv våtmark i Växjö. De kvarhållande och fördröjande effekterna som uppnås med gröna This thesis investigates the beneficial use of stormwater in Swedish urban environments. The focus has been on open stormwater systems for source control, as well as rainwater collection systems. To analyse the implementation of open stormwater systems, two case studies are presented: Augustenborg in Malmö and Bäckaslöv wetland in Växjö. The retention and detention effects of green-roofs have been
Popular Abstract in Swedish Autoimmun diabetes karakteriseras av cell medierad autoimmunitet mot insulinproducerande beta celler i Langerhanska öar. Typ 1 diabetes är den största typen av diabetes i barn och ungdomar och antas vara orsakad av Th1-cell drivet angrepp av beta celler. Den betydligt vanligare typ 2 diabetes antas inte vara en autoimmun sjukdom men diabetes specifika autoantikroppar (IAutoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. The much more prevalent type 2 diabetes is not considered as an autoimmune disease but diabetes specific autoantibodies (ICA
Popular Abstract in Swedish Enzymet magnesium-kelatas katalyserar bildandet av magnesium-protoporfyrin genom insättning av en magnesiumjon i protoporfyrin. Detta är det första unika steget i tillverkningen av klorofyll hos växter, alger och fotosyntetiska bakterier. Magnesium-kelatas består av tre proteiner som kallas I (vikt 40 kDa), D (70 kDa) och H (140 kDa). Det är viktigt att bestämma dessa pThe enzyme magnesium chelatase inserts magnesium into protoporphyrin IX (Proto) to produce to magnesium protoporphyrin IX, the first unique intermediate of the chlorophyll biosynthetic pathway. Magnesium chelatase is composed of three distinct proteins termed I (molecular weight ~40 kDa), D (~70 kDa) and H (~140 kDa). Defining the individual properties and structure of the magnesium chelatase comp
Popular Abstract in Swedish När vi tänker på skönlitteraturen får den gärna en drömmande klang som för tankarna till främmande platser långt borta från vardagen. Samtidigt kan skönlitteraturen måla upp slående bilder av världen och övertygande sätta in politiska och kulturella frågor i ett större meningsfullt sammanhang. Ingenstans blir detta tydligare än i Brands skönlitteratur. I det ungsocialisThis study delves into the relationship between fiction and politics, aesthetic and ethical messages conveyed by the fictions of Brand (Fire), the journal of the Young Socialist Association, founded as the Social Democratic Labour Party’s first youth association. The literary and aesthetic arena allowed many different kinds of ideas and thoughts to flourish, making Brand an important cultural pape
Nucleotide metabolism and replication of nucleic acids are processes of fundamental importance. A crucial enzyme in nucleotide metabolism is dUTPase (E.C. 3.6.1.23), that catalyses the hydrolysis of dUTP to dUMP and pyrophosphate. The activity of the enzyme has influence on the outcome of DNA replication and complete loss of enzyme activity is lethal, while a decreased activity promotes increased
Popular AbstractSyftet med avhandlingen är att undersöka på vilket sätt teater med ungdomar, enligt ungdomarnas egna erfarenheter och utsagor om det, utgör en kollektiv bildningsprocess. I avhandlingens syfte ingår att analysera hur en teaterföreställning växer fram och att skapa förståelse för vad som sker mellan olika aktörer, främst mellan ungdomar och ledare.Forskningsfenomenet, unga människorThe objective of this research project is to investigate in what way young people's theatre playing, according to their own experiences, constitute a collective educational process. Also, the project aims at understanding the interaction between the different actors, and particularly between the young amateurs and their leaders. Young people's acting in this research project is understood from a p
Popular Abstract in Swedish Blodet innehåller några av de mest grundläggande komponenterna för mänskligt liv. Med hjälp av hjärtats pumpkraft transporterar röda blodkroppar ut syre från lungorna till de mest avlägsna delarna av kroppen via gradvis tunnare blodkärl. Livshotande blödningar stoppas via blodplättarnas koagulerande förmåga och läkande egenskaper, medan de vita blodkropparna bekämpar inHematopoietic stem cells (HSCs) are defined by their capacity to self-renew and differentiate into all hematopoietic cell lineages. Postnatally, HSCs reside predominantly in the bone marrow and are relatively rare, but important cells because of their therapeutic potential in bone marrow transplantation protocols and in their involvement in the origin of certain leukemias. To study how various gen
The field of wireless communication is growing rapidly, with new requirements for the next generation of mobile and wireless communications technology. In order to achieve the capacities needed for future wireless systems, the design and implementation of advanced communications techniques such as multiantenna systems is required. These systems are realized by computationally complex algorithms, r
Popular Abstract in Swedish Tvärsektoriella nätverk mellan myndigheter, näringsliv och olika intressegrupper har tilldelats en allt större betydelse, då det varit en vanlig uppfattning att en hållbar utveckling bäst skapas genom ett gemensamt ansvar. Uppfattningarna om resultaten av dessa initiativ uppvisar dock spektakulära skillnader: från att framstå som oslagbara lösningar på de utmaningar soThe importance of cross-sectoral collaborative initiatives, that is partnerships of governments, civil society and the private sector, was elevated due to the belief that the issues of SD are a collective responsibility of all societal actors. The assessment of these initiatives is ranging dramatically; from giving them a status of an unbeatable solution for the SD challenges, to blaming them for
Popular Abstract in Swedish Antibiotikaresistens hos pneumokocker har utvecklats till ett problem i hela världen. Interkontinental spridning av ett fåtal resistenta kloner verkar stå för den snabba ökningen av förekomsten av pneumokocker med nedsatt känslighet för penicillin (PNSP). Förekomst av PNSP har reducerat behandlingsalternativen för såväl vanliga luftvägsinfektioner som invasiva infektionPneumococcal resistance to antibiotics has become a worldwide problem. The rapid increase in frequency seems to be caused by intercontinental spread of a few resistant clones. Resistance to antibiotics in pneumococci has reduced the therapeutic arsenal for common respiratory tract infections as well as for invasive infections. Problems of specific clinical concern are meningitis due to penicillin-
Popular Abstract in Swedish Förekomsten av sjukdomar inom det sk metabola syndromet (typ 2 diabetes, insulinresistans, övervikt, högt blodtryck och hjärt-kärlsjukdomar) ökar kraftigt i västvärlden. En viktig faktor för utvecklandet av detta syndrom är en försämrad insulinkänslighet. När kroppen utsätts för kontinuerligt höga insulinnivåer försämras känsligheten för detta hormon vilket resulterar iThe metabolic syndrome (type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, dyslipidaemia, and hyperinsulinaemia), is increasing in prevalence world-wide. The progression of this syndrome proceeds through a step-wise deterioration of metabolic events where deterioration of insulin sensitivity appears to have a key role in a ?vicious circle? of hyperinsulinaemia/hypergly
The physics program in Hall A at Jefferson Lab commenced in the summer of 1997 with a detailed investigation of the 16O(e,ep) reaction in quasielastic, constant (q,) kinematics at Q20.8 (GeV/c)2, q1 GeV/c, and 445 MeV. Use of a self-calibrating, self-normalizing, thin-film waterfall target enabled a systematically rigorous measurement. Five-fold differential cross-section data for the removal of p
Swedish engineering education is organised as study programs consisting of intertwined chains of course units. Formal program objectives integrate skills, scientific attitudes and engineering knowledge. However, assessment of learning and educational quality typically focuses outcomes of individual course modules. It is our concern that study programme quality and student progression are hard to e
IMPORTANCE The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general marker of damage to large-calibermyelinated axons. OBJECTIVE To test whether CSF NFL concentration is associated with cognitive decline and imaging evidence of neurodegeneration and white matter
Background: Adjuvant chemotherapy is standard treatment for other solid tumours, but to date has not proven effective in prostate cancer. Objective: o evaluate whether six cycles of docetaxel alone improve biochemical disease-free survival after radical prostatectomy for high-risk prostate cancer. Design, setting, and participants: Open-label, randomised multinational phase 3 trial. Enrolment of 4
