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Exhaled breath temperature has been suggested to reflect airway inflammation, and it would be plausible to measure the peripheral airway temperature as a correlate to peripheral airway inflammation. This study aims to explore the relative peripheral airway temperature in patients with asthma, chronic obstructive pulmonary disease (COPD) or systemic sclerosis (SSc) compared to healthy controls, and
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor het
Bacillus Calmette–Guérin (BCG) vaccine against tuberculosis (TB) is recommended given at birth in TB-endemic areas. Currently, BCG vaccination programmes use “BCG vaccination coverage by 12 months of age” as the performance indicator. Previous studies suggest that BCG-vaccinated children, who develop a scar, have better overall survival compared with BCG-vaccinated children, who do not develop a s
BACKGROUND: The four-kallikrein (4K) panel has been demonstrated to improve prediction of aggressive prostate cancer compared with prostate-specific antigen (PSA) among men with moderately elevated PSA levels. However, the development and testing of the 4K panel has been conducted primarily in White men, with limited data in African Americans and no studies in other racial and ethnic groups. METHO
Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urology met on February 21, 2020, in Amsterdam, The Netherlands, to formulate criteri
Assessments of long-term changes of air quality and global radiative forcing at a large scale heavily rely on satellite aerosol optical depth (AOD) datasets, particularly their temporal binning products. Although some attempts focusing on the validation of long-term satellite AOD have been conducted, there is still a lack of comprehensive quantification and understanding of the representativeness
OBJECTIVE: The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk.
Educational and income gradients in health are well established in the literature but there is need for a better understanding of how mental health inequalities change over time, and what drives the development. We aim to study how psychiatric diagnosis and its income-related inequality have changed over time in Sweden and to make a first attempt at disentangling the development by decomposing any
We have performed quantum mechanics (QM), molecular mechanics (MM) and hybrid QM/MM calculations to study the stereospecific proton exchange of glutathiohydroxyacetone (HOC-SG) by glyoxalase I (GlxI). We did the QM/MM calculations with a large QM system (246 atoms) to investigate the proton-exchange mechanism. Moreover, single-point big-QM energies with 1303 atoms in the big QM system and 22,412 a
Background. Oral contraceptive use has been previously associated with an increased risk of suicidal behavior in some, but not all, samples. The use of large, representative, longitudinally-assessed samples may clarify the nature of this potential association. Methods. We used Swedish national registries to identify women born between 1991 and 1995 (N = 216 702) and determine whether they retrieve
BACKGROUND: Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors.M
Cyclopentanone is a promising biofuel that can enable more efficient engine operation and increase the fuel economy of the light duty fleet over current and planned technology developments. While the ignition of cyclopentanone has been investigated in detail, more studies on the laminar burning velocities of cyclopentanone are called for. In this work, the laminar burning velocities of cyclopentan
Good knowledge on how increasing urbanization affects biodiversity is essential in order to preserve biodiversity in urban green spaces. We examined how urban development affects species richness and total abundance of butterflies as well as the occurrence and abundance of individual species within the Helsinki metropolitan area in Northern Europe. Repeated butterfly counts in 167 separate 1-km-lo
Transaktionsvolymerna för fastigheter i Sverige minskade med 42% under 2022, vilket har skapat en brist på referensobjekt för fastighetsvärderingar. Räntehöjningar och ökad inflation har skapat osäkerhet på marknaden och kan leda till stora konsekvenser för långivare och fastighetsföretag, samt den finansiella stabiliteten. Syftet med examensarbetet är att behandla problematiken vid fastighetsvärdThe transaction volumes for properties in Sweden decreased by 42% in 2022, which has created a shortage of reference objects for property valuations. Increased interest rate and inflation have created uncertainty in the market and can lead to significant consequences for lenders and real estate companies, as well as financial stability. The purpose of this thesis is to address the issues with prop
This thesis aims to shed light upon the cathar church and its expression of power and hierarchy in their rituals, such as the consolamentum, in conjunction with their theological view of said power and hierarchy. With a hermeneutic theory and a text analysis I read and aim to examine the cathars' own texts in its own context. Through my reading of their theological and ritual texts. I make the
At this point, railway switching systems exchange takes about 15 hours to perform. It means that long time is needed if performing multiple exchanges. It even means that traffic on tracks has to be disallowed for a long amount of time. It costs maintenance companies like Infranord a lot of money to keep tracks free from other vehicles during the work. The company needs to purchase special permissi
There are different kinds of foam with varying stability and appearance and a number of factors which affect this. The volume and the stability of the foam are important for the beer industry due to the fact that many consumers find this a measure of quality. There are many different methods for measurement of the physical properties of beer foam. Unfortunately none is used as a standard. A method
Ensuring energy security, eradicating energy poverty, and reducing GHG emissions from the energy sector are some of the key reasons why energy efficiency will be addressed in the Ukraine. The residential sector, being among the major energy consumers in the national economy, has a large energy saving potential. Multi-storey residential buildings currently require general refurbishment, and this fa
The purpose of this bachelor thesis is to develop an administration tool that will be used by a helpdesk in IKEA IT. The helpdesk members have a lot of responsibilities and have to perform various tasks on a daily basis, thus the goal is to develop an administration tool that has an interface which allows a helpdesk member to perform basic tasks without needing any prior education or experience of
Author: Jannica Nilsson Wallberg, Josefine Attnarsson Title: Substance abuse and pregnancy - Who is responsible for the unborn? A qualitative study from the professional perspective on compulsory treatment of pregnant substance abusers in Sweden and Norway [translated title] Supervisor: Eva Palmblad The purpose of this study was to examine the concept of compulsory treatment of pregnant women wi
