Filtyp
Background: beta-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5' region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. Methods: We examined the association between rs10993994 genotype and MSP l
Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data fr
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") and 2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) are hallucinogenic amphetamines with addictive properties. The hippocampus is involved in learning and memory and seems particularly vulnerable to amphetamine's neurotoxicity. We evaluated the neurotoxicity of DOI and MDMA in primary neuronal cultures of hippocampus obtained from Wistar ra
Context: Prostate cancer (PCa) is one of the most common human malignancies and arises through genetic and epigenetic alterations. Epigenetic modifications include DNA methylation, histone modifications, and microRNAs (miRNA) and produce heritable changes in gene expression without altering the DNA coding sequence. Objective: To review progress in the understanding of PCa epigenetics and to focus
Direct electron transfer (DET) from bare spectrographic graphite (SPGE) or 3-mercaptopropionic acid-modified gold (MPA-gold) electrodes to Trachyderma tsunodae bilirubin oxidase (BOD) was studied under anaerobic and aerobic conditions by cyclic voltammetry and chronoamperometry. On cyclic voltammograms nonturnover Faradaic signals with midpoint potentials of about 700 mV and 400 mV were clearly ob
Background Testicular dysgenesis syndrome (TDS) is a common disease that links testicular germ cell cancer, cryptorchidism and some cases of hypospadias and male infertility with impaired development of the testis. The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population. Methods To identify genetic v
The herbaceous understory forms the richest stratum in temperate broadleaved forests in terms of plant diversity. Understanding the process of understory succession is thus of critical importance for the development of management guidelines for biodiversity restoration in post-agricultural plantation forests. We studied effects of stand age, forest fragmentation, and soil and canopy conditions on
Plants can influence methane emissions from wetland ecosystems by altering its production, consumption and transport in the soil. The aim of this study was to investigate how eight vascular plant species from mesotrophic to eutrophic wetlands vary in their influence on CH4 emissions from peat cores, under low and high N supply. Additionally, we measured the production of low-molecular-weight organ
Reaction of Mn(II) with phenoxyalkanoic acids and di-2-pyridyl ketone oxime (Hpko) leads to neutral tetranuclear complexes of the general formula Mn-4(O)(pko)(4)(phenoxyalkanoato)(4) (phenoxyalkanoic acids: H-mcpa = 2-methyl-4-chloro-phenoxy-acetic acid, H-2,4,5-T = 2,4.5-trichloro-phenoxy-acetic acid or H3,4-D = 3,4-dichloro-phenoxy-acetic acid). The compounds were synthesized by adding di2-pyrid
We have previously reported that liver X receptor (LXR) agonist, TO901317, could significantly inhibit hepatic apolipoprotein M (apoM) expression. It has been reported that TO901317 could activate the ATP-binding cassette transporter A1 (ABCA1) that mediates cholesterol efflux to the lipid-poor apoA1, which is an essential step for the high-density lipoprotein (HDL) formation. It is unknown if ABC
Three types of estrogen receptors (ER) exist in the heart, Esr1, Esr2 and the G protein-coupled estrogen receptor 1, Gper1. However, their relative importance in mediating estrogen protective action is unknown. We found that, in the male mouse ventricle, Gper1 transcripts are three- and seventeen-fold more abundant than Esr1 and Esr2 mRNAs, respectively. Analysis of the three ER knockouts (Esr1-/-
The main purpose with this Master's thesis has been to through a case study investigate and analyze the music library activity at the Public Library in Lund, in order to find out according to which ideas and principals this activity is run by. It also discusses how you at the music department handle your task as intermediary of music and how well this coincides with the users expectations. To
Abuse of alcohol is one of the biggest problems that society faces today. There are between three and four hundred thousand abusers in Sweden. In addition there are about three hundred thousand over consumers. The government bill proposed in 1977 gave the labour market most of the responsibility to solve the problem. They thought a meaningful job and a spirit of community were the most important f
A large-scale international report recently published by Transgender Europe shows great discrepancy between the patients’ and the caregivers’ views on transgender care. Apart from this report, those working in transgender care have yet to make their voices heard. However, transgender individuals as well as organizations working with issues of the transgender and queer communities in Sweden have be
The aim of this master’s thesis is to examine the preservation of audiovisual objects and how methods surrounding this may affect the material as well as the archival profession. Physical recording formats – such as cassette tapes or compact discs – deteriorate quickly and are becoming progressively obsolete, which in turn makes it problematic to safeguard the information they contain. It is there
The topic of Basic Colour Terms (BCT) and their proposed universality has long been a source of debate within linguistics. Whether colour terms (as symbols) fill lexical gaps of presumed universal colour categories (as senses) or not is relevant for the debate regarding linguistic relativity: the hypothesis about the influence of language on the way we think. Until now, there has been a focus on
Ever since the EU’s sanctions against Russia were imposed in 2014, the bloc has managed to keep a united stance outwards. Under the surface, the measures have however generated sharp divisions among some of the Member States, where one faction wants to scrap the sanctions, while another faction wants to see them expanded. Divisions of this proportion are unprecedented in the EU’s sanctions history
Since the building stock stands for significant part of the EU’s total energy use, energy renovations are needed in order to lower the negative environmental impacts. In Sweden, only 1 % of the total building stock is newly built i.e. the focus should be directed upon existing buildings. Moreover, most of the buildings in the “Million Program” from 1970´s are in need of renovations in order to kee
Offentliga upphandlingar utgör en stor del av de svenska och europeiska marknaderna och har sedan länge varit föremål för reglering som bland annat ska minska risken för korruption och säkerställa ett effektivt utnyttjande av offentliga medel. Sedan Sveriges tillträde i Europeiska ekonomiska samarbetsområdet 1992 har upphandlingsreglerna utgått från dem som framarbetats av Europeiska unionen. Det Public procurement constitutes a large part of Swedish and European markets and has since long been subject to regulation in order to, inter alia, decrease the risk of corruption and securing an effective use of public means. Since Sweden’s entry to the European Economic Area in 1992, existing rules of public procurement have originated from the rules drafted by the European Union. There exists a
I Sverige råder strandskydd vid alla vattensamlingar och vattendrag. Lagstift-ningen är ett resultat av en rättsutveckling som pågått sedan 1940-talet. År 1974 fick Sverige ett generellt strandskydd med möjlighet för dispens för den enskilde. Under 1990-talet utvecklades strandskyddets syften till att även omfatta skydd för djur- och växtarter. Idag debatteras strandskyddets framtid i riksmedia oc
