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This study examines and compares theoretical CDS spreads created by a structural framework with empirical CDS spreads. The model employed is the CreditGrades model based on the Merton framework from 1974 which calculate default probabilities and credit spreads from balance sheet and equity data. The aim is to measure how well the model can explain the observed CDS spreads and if it has any predict
The purpose of this qualitative study was to research how people's experience of having a sibling with an autism spectrum disorder affected their upbringing. We held six semi-structured interviews where we examined three different aspects of the participants’ lives in regard to their upbringing and sibling. 1: Their relationship with their sibling. 2: Their role in the family. 3: What kind of
Detta examensarbete handlar om PLC-programmering av en pelletspanna till ett nytt fjärrvärmeverk som byggs i Landskronas stadsdel Örja i samarbete med Deterministic Control AB, för en slutkund Landskrona Energi AB. Material som P&I-schema, funktionsbeskrivning, I/O-lista levererades av ett annat företag, AKJ. All programmering görs i ett ABB 800xA-system. De viktiga begrepp som examensarbetet
This thesis aims to explore the possibility of using deep learning techniques to mine opinions on Twitter, with the objective to predict the political opinion distribution in Sweden. Different methods of gathering and annotating training data are evaluated to achieve accurate and reliable predictions. The models are quite successful at predicting test data, achieving F1-scores in the range of 70 %
Despite a global increase in gender equality, intimate partner violence (IPV) still plagues all nations. Moreover, IPV is still a heavily stereotyped crime where women are victims and men are perpetrators. Due to the gendered nature of IPV, information that either conforms or deviates from gender expectations can change the perceptions of perpetrators and victims of IPV. The present study investig
Syftet med studien var att närma oss hur psykodynamiskt inriktade terapeuter som arbetar med barn med traumatiska erfarenheter, upplever sin kliniska verklighet och att få en inblick i på vilket sätt psykodynamisk barnterapi kan göra skillnad för dessa barn. Studien är uppbyggd på en kvalitativ grund och utgår från tolkande fenomenologisk anlays, IPA, (Interpretative Phenomenological Analysis). DaThe aim of the study was to approach how psychodynamically oriented therapists who work with children with traumatic experiences, experience their clinical reality and to gain an insight into how psychodynamic child therapy can make a difference for these children. The study is based on a qualitative basis and is based on interpretive phenomenological analysis, IPA, (Interpretative Phenomenologica
In continental margin basins, the hydrogeological setting is complex due to transgression/regression events that removed old sediments in the basin and formed new geologic units. Due to the geological complexity, the use of vertical electrical sounding has proven to be insufficient for groundwater explorations. The lack of understanding the geological underground has resulted in many boreholes wit
Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly associated with incident type 2 diabetes mellitus (T2DM). However, their causal roles in T2DM are unclear. In an incident T2DM case-cohort study nested within the populationbased European Prospective Investigation into Cancer and Nutrition (E
BackgroundPrioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.AimsTo explore the interactive network of inflammation, depression and cog
Context:Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1) and 14q13.2 (NKX2-1). However, most of the inherited genetic risk factors of DTC remain to be discovered.Objective:Our objective was to identify additional common DTC susceptibility loci.Design:We conducted a GWAS in a
The plant respiratory chain contains several pathways which bypass the energy-conserving electron transport complexes I, III, and IV. These energy-bypasses, including type II NAD(P)H dehydrogenases and the alternative oxidase (AOX), may have a role in redox-stabilisation and regulation, but current evidence is inconclusive. Using RNA interference, we generated Arabidopsis thaliana plants simultane
Recent studies have revealed bacterial genome-wide evolution to be complex and dynamic even in a constant environment, characterized by the emergence of new clades competing or temporarily coexisting as each clade undergoes evolutionary change. Previous studies on predator-prey dynamics tracking simple ecological and phenotypic metrics have shown predation to fundamentally alter prey evolution, fa
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
This paper examines how extreme weather events affect the mobility of low-income urban residents in Ghana. Bringing together scholarship on extreme weather and mobilities, it explores the differential impact of flooding on their everyday lives as they navigate the cities of Accra and Tamale. A range of qualitative methods were drawn on, including semi-structured interviews, focus group discussions
At the turn of the twentieth century, infant- and child mortality declined rapidly in many industrializing societies. In Sweden, this decline coincided with industrialization and urbanization, as well as a period of growing social disparities in childhood mortality. The inequality in child survival was connected to a range of factors, including access to water- and sanitation, housing conditions,
Introduction: Therapeutic proteins are crucial in the treatment of a wide range of diseases. However, the proteins are sensitive to chemical degradation reactions, particularly deamidation and isomerization, which can compromise efficacy and safety. Formulation excipients, such as sugars and non-ionic surfactants, are commonly used to enhance stability, yet their effects on chemical degradation re
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here we present Proteomics-based Artificial Intelligence for Dementia Diagnosis (ProtAIDe-Dx), a deep joint-learning model
BACKGROUND: People with intellectual disabilities (ID) are known to have a higher risk for a wide range of health conditions compared to the general population. However, there is little research comparing a more comprehensive range of diseases and conditions at different ages. Therefore, the aim of this study was to explore the overall age-specific diagnostic pattern among people with ID compared
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-
