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Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also cl
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is today considered a novel specific vascular inflammatory biomarker. The general aim of this thesis was to study the role and impact of Lp-PLA2 as cardiovascular (CV) risk marker in an epidemiologic perspective. Specific aims were to explore the cross-sectional association of Lp-PLA2 with traditional CV risk factors, to asses the genetic influence
The aim of the user related assessment was to study perceived advantages, disadvantages, usefulness, trust, acceptance, willingness to have and pay for the driver assistance systems: Safe Cruise and Speed Support developed by VCC within the framework of SECONDS subproject. Due to restrictions in driving in real traffic, assessment activities were limited to driving on a test track by naïve test dr
Popular Abstract in Swedish Prostata cancer är en av de vanligast förekommande cancerformerna hos män i västvärlden och den vanligaste förekommande hos män i Sverige. Årligen diagnosticeras i Sverige ungefär 6000 fall och mer än 2000 avlider. Drygt 70% av alla som drabbas är äldre än 70 år medan endast ett fåtal är yngre än 50 år. Sjukdomen ter sig mycket olika hos olika patienter. En del som drabHuman glandular kallikrein 2 (hK2) is a predominantly prostate produced protein with many similarities to prostate-specific antigen (PSA). Just like for PSA elevated levels of hK2 can be found in men with protate cancer. We created an assay where hK2 in serum could reliably and with negligible cross-reactivity with PSA, be measured down to 0.030 ng/mL. The assay measured free hK2 and hK2 complexe
Background. Compounds that block uterine oxytocin and vasopressin V1a receptors have a therapeutic potential in preterm labor and primary dysmenorrhoea. The orally active vasopressin V1a receptor antagonist, SR49059, inhibits the effect of vasopressin on human uterine activity in vivo, but the influence on the response to oxytocin is unknown. Methods. In a placebo-controlled, double-blind, parall
Background: CD4-independence has been taken as a sign of a more open envelope structure that is more accessible to neutralizing antibodies and may confer altered cell tropism. In the present study, we analyzed SIVsm isolates for CD4-independent use of CCR5, mode of CCR5-use and macrophage tropism. The isolates have been collected sequentially from 13 experimentally infected cynomolgus macaques and
Context: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. Objective: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these
The role of oxidants in viral diseases is fairly complex because it includes metabolic regulation both of host metabolism and viral replication. However, a role for reactive oxygen species (ROS) and reactive nitrogen species (RNS) as mediators of virus-induced lung damage is supported by studies and antioxidants can thus be expected to act at many different levels. The aim of the present pilot stu
Background & Aims: The Glu167Lys (E167K) variant in the transmembrane 6 superfamily member 2 protein (TM6SF2) was recently shown to influence liver fat (LFAT) content. We aimed at studying how this variant influences circulating triacylglycerol (TAG) signatures and whether it influences hepatic or adipose tissue insulin sensitivity. Methods: We genotyped 300 Finnish subjects for the E167K (rs5
OBJECTIVE: Increased inflammation and oxidative stress have been shown in Major Depressive Disorder (MDD), although there is significant heterogeneity across studies. Whether markers of inflammation and oxidative stress are associated with antidepressant treatment response in MDD is currently unclear. The goals of the present study are to investigate markers of inflammation and oxidative stress in
Lithium ion batteries enable the implementation of renewable energy and electric vehicles, both of which are crucial for the transition to a sustainable society. Due to environmental, economic and political reasons, these batteries must be recycled efficiently. Most lithium ion batteries are placed on the market in electric vehicles, which are reaching end-of-life at an exponential pace, prompting
Lagen om hemlig dataavläsning trädde i kraft den 1 april 2020. Lagen innebär att brottsbekämpande myndigheter, utöver säkerhetspolisen, kan få tillgång till innehållet i den enskildes mobiltelefon och dator. Särskilt vid tvångsmedelslagstiftning är det viktigt att lagstiftaren förhåller sig till de rättsliga principer och begrepp som gäller på ett korrekt vis. Denna uppsats ämnar att kritiskt graThe Secret data interception law was implemented on 1 of April, 2020. The law allows law enforcement authorities, not just the security police, to gain access to information from an individuals' mobile phone and computer. In the case of coercive measures legislation, it is important that the legislator relates to the corresponding legal principles and concepts in a correct way. This essay in
Study I: Thirteen patients underwent a modified Ross operation in which the free-standing pulmonary autograft was supported externally by a Dacron vascular prosthetic jacket (DVPJ). The tailor-made DVPJ prevented dilatation of the neo-aortic root significantly following a median follow-up of 47 months compared to a cohort of l3 matched patients undergoing conventional Ross operation. Study II: A
The cardiovascular risk for users of use of Swedish snus/American snuff (moist tobacco) has been debated for a long time. The present study was designed to examine the effects of water- or lipid-soluble (DMSO-soluble) snus and nicotine, the most important substance in tobacco, on the expression of vasocontractile G-protein coupled receptors (GPCR), such as endothelin ETB, serotonin 5-HT1B, and thr
Identification and isolation of cardiomyocytes from the heart, embryonic stem cells, or induced pluripotent stem cells is a challenging task and will require specific isolation techniques. Less than 30% of the cells within the murine heart are cardiomyocytes and, what is more, there are multiple sub-populations of cardiomyocytes like atrial, ventricular and conduction system cardiomyocytes. In Pap
Accumulated carbon uptake, apparent quantum yield (AQY) and light-saturated net CO2 assimilation (A(sat)) were used to assess the responses of photosynthesis to environmental conditions during spring for three consecutive years. Whole-tree chambers were used to expose 40-year-old field-grown Norway spruce trees in northern Sweden to an elevated atmospheric CO2 concentration, [CO2], of 700 mu mol C
Denna uppsats försöker att klargöra huruvida det, sedan 2007 års Lavaldom, har skett en utveckling inom EU-rätten som tillåter att stridsåtgärder används i ett ökat antal fall, och huruvida den senaste ändringen av den svenska utstationeringslagen är i samklang med nuvarande EU-rätt. Uppsatsen fokuserar på EU-rätt och svensk rätt, och folkrätten är därför utelämnad. Utstationeringsdirektivet, utfäThis thesis tries to elucidate whether, since the Laval judgment of 2007, there has been a development in EU law allowing for collective action to be used in a greater amount of cases, and whether the latest amendment to the Swedish Posting of Workers Act is in accordance with the current EU law. The thesis focusses on EU law and Swedish law, and international law is thus omitted from its scope. T
Obtaining microstructural information non-invasively on brain tissue remains a challenge. Diffusion magnetic resonance imaging (dMRI) is an imaging method that can provide such information. That includes geometrical considerations of nerve cells projections, axons, that are present in the white matter of the human brain. Axons carry information encoded into electrical impulses to other cells. The
Genom en större lagreform, från år 2004, infördes nya bestämmelser i 6 kap., bland annat i syfte att förstärka skyddet för barn mot sexuella övergrepp. En av dessa var bestämmelsen om våldtäkt mot barn som bland annat kriminaliserar samlag eller med samlag jämförlig handling med barn under femton år. En lindrigare form av våldtäkt mot barn, sexuellt utnyttjande av barn, infördes med samma reform. In 2004, reforms were made in chapter 6 of the Penal Code in regards to strengthen the protection for children against sexual assaults. One of these was the provision regarding child rape that outlaws intercourse or comparable actions to intercourse with children under the age of fifteen. A minor form of child rape, sexual use of children, was implemented with the same reform. This was intended to
Title: The perceived innovativeness of the manufacturing process and perceived product quality. The case of creative and technology-intensive industries. Course: BUSN39 Degree Project in Global Marketing Authors: Federica Piccone & Joanna Pilawa Supervisor: Javier Cenamor Keywords: manufacturing process; perceived innovativeness; perceived quality Thesis Purpose: The main purpose is to
